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Multi-drug phased continuous controlled-release drug delivery system and preparation method thereof

A drug delivery system and staged technology, which is applied in the field of multi-drug staged continuous controlled release drug delivery system and its preparation, can solve the problems of expensive processing equipment, complicated operation, and dangerous electrospinning technology

Active Publication Date: 2019-06-21
西安博恩生物科技有限公司
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Problems solved by technology

This method can only realize the time-sharing release of the two drugs, and the processing equipment used in this method is expensive and the operation is complicated, and the electrospinning technology has certain risks.
The prepared drug-loaded scaffolds are only suitable for the repair of bone defects

Method used

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  • Multi-drug phased continuous controlled-release drug delivery system and preparation method thereof
  • Multi-drug phased continuous controlled-release drug delivery system and preparation method thereof
  • Multi-drug phased continuous controlled-release drug delivery system and preparation method thereof

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Embodiment Construction

[0043] like figure 1 As shown, the multi-drug staged continuous controlled release drug delivery system in the present invention is spherical, and its matrix material is sodium alginate (SA) hydrogel doped with different drug-loaded microspheres, and the drug-loaded microspheres are released in the order of Distributed along the radial direction of the system. That is, the microspheres that release the drug first are distributed on the surface of the system (the outermost layer of the sphere), and the microspheres that release the drug last are distributed in the center of the system (the center of the sphere). Layered distribution from outside to inside.

[0044] The basic process of the drug delivery system preparation method is:

[0045] Polyethylene lactide-polyethylene glycol monomethyl ether (PLGA-mPEG) block copolymer is used as the drug-loading matrix, and different drugs are respectively encapsulated by solvent evaporation method to form different drug-loaded micros...

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Abstract

The invention provides a multi-drug phased continuous controlled-release drug delivery system and a preparation method thereof. The system is spherical, takes sodium alginate hydrogel doped with polyglycolide-polyethylene glycol monomethyl ether block copolymer drug-carrying microspheres as a matrix material, adopts a multi-nozzle 3D printer to sequentially print a sodium alginate solution mixed with different drug-carrying microspheres from outside to inside in a radial direction according to a prescribed drug release sequence, and extruded materials are quickly crosslinked and shaped under the action of a calcium chloride solution. By controlling the molar ratio of lactide to glycolide in a drug-carrying matrix PLGA-mPEG and a molding position of the sodium alginate hydrogel doped with different drug-carrying microspheres, the phased continuous controlled release of multiple drugs can be achieved.

Description

technical field [0001] The invention belongs to the technical field of drug controlled release, and in particular relates to a multi-drug staged continuous controlled release drug delivery system and a preparation method thereof. Background technique [0002] Loading drugs or cytokines into drug delivery systems and controlling their release has become an effective treatment for many diseases, especially promising in tissue regeneration engineering. The treatment of many diseases requires long-term combined application of multiple drugs. For example, in bone tissue engineering technology, especially in the process of jaw bone reconstruction, different growth factors need to be administered at different stages of bone formation to exert synergistic effects between cytokines and promote bone formation. Proliferation, differentiation and expression of osteoblasts, thereby promoting bone reconstruction. Therefore, a single drug-loaded sustained-release system cannot meet the cu...

Claims

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Application Information

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IPC IPC(8): A61K47/34A61K47/36A61K9/16B33Y10/00B33Y80/00C08G63/08C08G65/331
Inventor 汪焰恩尹光德魏庆华郭莹张坤王艳梅
Owner 西安博恩生物科技有限公司
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