Elastic membrane, and preparation method and application thereof
An elastic film and prefabricated technology, applied in the field of medical devices, can solve the problems of reduced adhesion probability, serious side effects of patients, and growth of endometrium, etc., and achieves high biocompatibility, uniform and stable degradation process, and uniform and stable release. Effect
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Embodiment 1
[0077] This embodiment provides an elastic membrane, which includes silicone rubber and a coating on the surface of the silicone rubber. The silicone rubber is obtained by performing plasma treatment on the surface of the prefabricated silicone rubber, and the drug is atomized into a particle size of 10 -300 μm; Wherein coating comprises medicine and controlled-release factor, and wherein medicine is estradiol, and controlled-release factor is D-polylactic acid, the mass ratio of the two is 10%:90%, and the thickness of coating is 0.1mm; Wherein The content of estradiol in an elastic membrane is 10mg; The thickness of the elastic membrane is 0.5mm, the shape is an inverted trapezoid, the height of the inverted trapezoid is 30mm, the length of the upper bottom is 30mm, and the length of the lower bottom is 10mm. The modulus is 1.2MPa.
[0078] This embodiment also provides a preparation method of an elastic film, the preparation method is as follows:
[0079] (1) Weigh a certa...
Embodiment 2
[0091] The difference from Example 1 is only that the estradiol in Example 1 is micronized, and its particle size is 2000 mesh, and the rest of the composition and preparation method are the same as in Example 1.
[0092] Use a drug dissolution tester to dissolve the drug in the PBS solution at 37°C, and test the amount of dissolved drug by HPLC. It can be seen that within 30 days, the maximum amount of drug dissolved in the first 7 days was 317 μg / d, and then gradually stabilized and slowed down, and within 30 days The average release rate was 276μg / d.
[0093] figure 2 Comparison of release curves in vitro for 30 days for the elastic films prepared in Example 1 and Example 2.
Embodiment 3
[0095] This embodiment provides an elastic film, the elastic film includes silicon rubber and a coating on the surface of the silicon rubber, the silicon rubber is obtained by wiping and swelling the surface of the preformed silicon rubber with isopropanol, and the medicine is atomized into The particle size is 10-300 μm; wherein the coating includes a drug and a controlled release factor, wherein the drug is estradiol, and the controlled release factor is D-polylactic acid, the mass ratio of the two is 28%:72%, and the thickness of the coating is 0.2mm; the content of estradiol in one of the elastic membranes is 20mg; the thickness of the elastic membrane is 0.1mm, the shape is an inverted trapezoid, the height of the inverted trapezoid is 25mm, the length of the upper bottom is 20mm, and the length of the lower bottom is 5mm. The modulus of elasticity of the elastic film was 1.2 MPa.
[0096] This embodiment also provides a preparation method of an elastic film, the preparat...
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Abstract
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