A class of coumarin hydrazone compound, its preparation method and application
A compound, coumarin technology, applied in chemical instruments and methods, organic chemistry, material excitation analysis, etc., can solve the problems of disturbing endogenous formaldehyde concentration, slow detection response, poor sensitivity, etc.
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Embodiment 1
[0055]Example 1: Preparation of I-1
[0056]
[0057]Compound I-1A and Lawson reagents reflow in dried toluene. The reaction ends, cooling filtration, filtration, and dissolved in ethanol after drying solvent, 80% hydrated hydrazine, reflow reaction. After the reaction was completed, the carnivore was added, and the water was added three times with dichloromethal, combined with an organic phase, sodium anhydrous sodium sulfate, and purified, gave I-1 (yield 65%). LC-MS: M / Z 256.145 [M + H]+.
Embodiment 2
[0058]Example 2: Preparation of II-1
[0059]
[0060]Compound II-1A and Lawsen reagents reflow in dry toluene. The reaction ends, cooling filtration, filtration, and dissolved in ethanol after drying solvent, 80% hydrated hydrazine, reflow reaction. After the reaction was completed, the carnifened solvent was added, and the water was added three times with dichloromethydehyde, and the organic phase, sodium alhydrate sodium sulfate was combined, and the column chromatography was purified to give II-1 (yield 68%). LC-MS: M / Z254.1293 [M + H]+.
Embodiment 3
[0061]Example 3: Preparation of II-2
[0062]
[0063]Compound II-2A and Lawn reagents reflow in dry toluene. The reaction ends, cooling filtration, filtration, and dissolved in ethanol after drying solvent, 80% hydrated hydrazine, reflow reaction. After the reaction was completed, the carnifecene was added, and the water was added three times, and the organic phase, dried over anhydrous sodium sulfate was combined, and the column chromatography was purified to give II-2 (yield 73%). LC-MS: M / Z296.1340 [M + H]+.
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