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Method for improving clarification stability of Shuanghuanglian oral liquid preparation

A Shuanghuanglian oral liquid and stability technology, which is applied in the field of veterinary Shuanghuanglian oral liquid preparation and its extraction and refining, can solve the problems of complex process operation, high cost, increased production cost, etc., shorten the process flow, realize solid Liquid separation, the effect of stabilizing production costs

Inactive Publication Date: 2019-07-09
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, the production process of veterinary Shuanghuanglian oral liquid follows the process recorded in the second part of the Veterinary Pharmacopoeia of the People's Republic of China in 2015. The process operation is complicated and the cost is high
Shuanghuanglian oral liquid products produced by commercial companies using medicinal materials extraction generally do not meet the quality requirements for clarification; while ultrafiltration treatment can improve the clarity of the solution, but it causes the loss of active ingredients of large molecular weight traditional Chinese medicine and the stability of the clarification system is poor , it is difficult to maintain for a long time; at the same time, ultrafiltration treatment has high requirements on process equipment and is easy to limit production capacity and increase production costs

Method used

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  • Method for improving clarification stability of Shuanghuanglian oral liquid preparation

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Effect test

Embodiment 1

[0028] A method for improving the clarification stability of Shuanghuanglian oral liquid preparations, comprising the following steps:

[0029] (1) Scutellaria baicalensis slices; add water and boil for extraction 3 times (10 times water for 2 hours for the first time, 8 times water for 1 hour for the second and third times); combine the extracts, concentrate under reduced pressure to a specific gravity of 1.03 (80°C); concentrate The liquid was centrifuged while it was hot (3500 rpm); the centrifuged liquid was added with 2mol / L hydrochloric acid solution to adjust the pH value to 2.0, and the acid precipitation was allowed to stand for 12 hours; filtered, and the precipitate was collected for later use, which was the Scutellaria baicalensis extract;

[0030] (2) Honeysuckle and Forsythia add water and boil for 2 extractions (10 times water for 1.5 hours for the first time, 8 times water for 1.5 hours for the second time); combine the extracts and concentrate to a specific gra...

Embodiment 2

[0035] A method for improving the clarification stability of Shuanghuanglian oral liquid preparations, comprising the following steps:

[0036] (1) Scutellaria baicalensis slices; add sodium bicarbonate to adjust the pH value of the extraction water to 10.0, and extract by boiling for 3 times (10 times of water for 2 hours for the first time, 1 hour for the second and third times of 8 times of water each); combine the extracts, reduce Concentrate under pressure to a specific gravity of 1.05 (75°C); centrifuge the concentrated solution while it is hot (12000rpm); add 2mol / L hydrochloric acid solution to the centrifuged solution to adjust the pH value to 2.0, and let the acid settle for 12 hours; filter and collect the precipitate for later use, which is the extraction of Scutellaria baicalensis thing;

[0037] (2) Honeysuckle and Forsythia add water and boil for 2 extractions (10 times water for 1.5 hours for the first time, 8 times water for 1.5 hours for the second time); com...

Embodiment 3

[0042] A method for improving the clarification stability of Shuanghuanglian oral liquid preparations, comprising the following steps:

[0043] (1) Scutellaria baicalensis slices; add sodium bicarbonate to adjust the pH value of the extraction water to 8.0, boil and extract 3 times (use 10 times of water for 2 hours for the first time, and 1 hour for the second and third times of 8 times of water each); combine the extracts, reduce Concentrate under pressure to a specific gravity of 1.05 (75°C); centrifuge the concentrated solution while it is hot (8000 rpm); add 2 mol / L hydrochloric acid solution to the centrifuged solution to adjust the pH value to 2.0, and let the acid settle for 12 hours; filter and collect the precipitate for later use, which is the extraction of Scutellaria baicalensis thing;

[0044](2) Honeysuckle and Forsythia were extracted twice by boiling with water (1.5 hours with 10 times water for the first time, 1.5 hours with 8 times water for the second time)...

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Abstract

The invention discloses a method for improving the clarification stability of a Shuanghuanglian oral liquid preparation. The method includes respectively preparing a baical skullcap root extract, a honeysuckle flower extract and a weeping forsythia extract, and centrifugally removing impurities from concentrated solutions of the honeysuckle flower extract and the weeping forsythia extract; dissolving the baical skullcap root extract by a buffer salt solution, and mixing the dissolved baical skullcap root extract with the honeysuckle flower extract and the weeping forsythia extract. The methodfor improving the clarification stability of the Shuanghuanglian oral liquid preparation is clear and highly stable.

Description

technical field [0001] The invention relates to a method for improving the clarification stability of Shuanghuanglian oral liquid preparation, in particular to a veterinary Shuanghuanglian oral liquid preparation and its extraction and refining method. Background technique [0002] Shuanghuanglian Oral Liquid is a compound preparation of pure traditional Chinese medicine widely used in veterinary clinics. It is composed of three traditional Chinese medicines: Scutellaria baicalensis, honeysuckle and forsythia. disease treatment. [0003] Shuanghuanglian oral liquid has been widely used so far because of its good curative effect, and has remarkable curative effect in preventing and treating influenza and inhibiting bacteria. In recent years, with the development and scale expansion of the breeding industry, antibiotics have been widely used in the prevention and control of livestock and poultry. At the same time, the abuse of antibiotics in the population has become increasi...

Claims

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Application Information

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IPC IPC(8): A61K36/634A61K9/08A61K47/12A61K47/02A61P29/00A61P11/00
CPCA61K9/0095A61K36/355A61K36/539A61K36/634A61K47/02A61K47/12A61K2236/331A61K2236/51A61K2236/53A61K2300/00
Inventor 黄松史德胜孙月川王一凡
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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