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Bone repair material and preparing method thereof

A bone repair and preparation process technology, applied in the field of medical bone repair, can solve the problems of limited optional parts of the bone harvesting area, lack of ability to solidify and form, and easy to cause immune reactions, etc., to achieve good biocompatibility and good bioavailability Absorbability, the effect of simple and easy preparation process

Active Publication Date: 2019-07-12
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limited selection of bone harvesting areas in the body and the high risk of complications, new obstacles are created for autologous bone transplantation
(2) Allogeneic bone: The source of allogeneic bone is far more than that of autologous bone, but because it is transplanted between different individuals, it has different genetic characteristics, which can easily cause immune reactions and cross-infection
[0005] At present, the clinically used materials for bone repair cannot meet all the above conditions at the same time, especially the lack of the ability to quickly solidify and form at the traumatic site of bone tissue, thus forming a technical bottleneck

Method used

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  • Bone repair material and preparing method thereof
  • Bone repair material and preparing method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation of embodiment 1 bone repair material

[0020] According to the composition of each experimental group and control group of bone repair materials in Table 1, weigh each component, crush the adipose tissue decellularized matrix, dissolve it in 30ml of distilled water, add 40ml of silk fibroin, palmitoyl four Peptide-7 solution, mix well, finally add 10ml of indocyanine green solution, mix well, add distilled water to a final volume of 100ml, to form a uniform gel of bone repair material.

[0021] Table 1 The amount of components in each experimental group and control group of bone repair materials

[0022]

[0023]

[0024] Note: " / " indicates that the component is 0; "()" indicates that the component in brackets is used instead of the component.

Embodiment 2

[0025] Performance testing and application effect of embodiment 2 bone repair material

[0026] Each experimental group and control group of the bone repair material in Example 1 were irradiated with 785nm near-infrared light for 60 seconds, and the following performance indicators of the bone repair material in each group were observed and evaluated.

[0027] (1) Performance index detection of bone repair materials in each group

[0028] Appearance: the porosity and pore size of the surface of the bone repair materials in each group were observed under the light microscope and scanning electron microscope, whether they were uniform or not.

[0029] Water absorption: Weigh the quality Wo value of the bone repair material, then place it in a weighing bottle filled with deionized water, fully swell, dry the surface moisture with filter paper, weigh the weight to obtain the Wn value, and calculate the water absorption of the sample: water absorption ( %)=[(Wn-Wo) / Wo]×100

[003...

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Abstract

The invention provides a bone repair material. The bone repair material mainly comprises adipose tissue acellular matrix, palmityl tetrapeptide-7, silk fibroin, heparin poloxamer and indocyanine green. The bone repair material is irradiated by 785 nm near-infrared light, and then quickly solidified to form a three-dimensional elastic grid structure matched with bone defect tissue. The bone repairmaterial has various excellent performance indexes, good biocompatibility and a good bone trauma repair effect, and can be used as a replacement transplant of bone tissue for orthopic transplantationrepairing of bone tissue traumas.

Description

technical field [0001] The invention relates to the field of medical bone repair, in particular to a rapidly prototyping, efficient and safe bone repair material and a preparation method thereof. Background technique [0002] In recent years, there have been more and more bone traumas caused by car accidents, disasters, etc., and the repair process of bone trauma is complex and lengthy, seriously affecting people's activities and quality of life. [0003] Bone repair materials are the key to achieve bone trauma treatment. At present, bone repair materials include: (1) autogenous bone: refers to the bone from a certain part of the body moved to another place, but it is only suitable for the treatment of local small area bone trauma. Due to the limited selection of bone harvesting areas in the body and the high risk of complications, new obstacles are created for autologous bone transplantation. (2) Allogeneic bone: The source of allogeneic bone is far more than that of auto...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/20A61L27/22A61L27/50A61L27/56A61L27/58
CPCA61L27/20A61L27/227A61L27/3633A61L27/50A61L27/56A61L27/58A61L2430/02C08L89/00C08L5/10
Inventor 赵应征鲁翠涛徐荷林姚情杨外庚陈睿
Owner WENZHOU MEDICAL UNIV