Synthesis method of quinocetone
A synthetic method and quinocetone technology, which is applied in the field of synthesis of veterinary drug quinocetone, can solve the problems of difficulty in obtaining high-yield qualified products and difficulties in purification, and achieve the effects of simple and convenient production process, excellent yield, and mild reaction conditions
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Embodiment 1
[0032] Weigh 1.2 g of valine, 1 g of 4-picoline, and 5 g of diethylene glycol, add them into a 250 ml reaction flask, add 80 ml of purified water, and stir to clarify the system.
[0033] Weighed 21.8 g of methaquine and 13.8 g of benzaldehyde respectively, added them to the above catalytic system, heated to 40° C. for 6 hours, and HPLC detected that the reaction of methaquine was complete, cooled, and suction filtered to obtain the crude quinocetone.
[0034] Add 60 ml of methanol to the crude quinocetone, stir for 1 hour, filter with suction, and dry in vacuum to obtain 27.6 g of the product with a yield of 90% and a purity of 98.2%.
Embodiment 2
[0036] Weigh 1 g of phenylalanine, 0.5 g of pyridine, and 2 g of triethylene glycol, add them into a 250 ml reaction flask, add 80 ml of pure water, and stir to clarify the system.
[0037] Weighed 21.8 g of methaquine and 12.8 g of benzaldehyde respectively, added them to the above catalytic system, heated to 40° C. and reacted for 4 hours, HPLC detected that the reaction of methaquine was complete, cooled, and suction filtered to obtain the crude quinocetone.
[0038] Add 80 ml of methanol to the crude quinocetone, stir for 1 hour, filter with suction, and dry in vacuum to obtain 28.1 g of the product with a yield of 92% and a purity of 98.1%.
Embodiment 3
[0040] Weigh 1.5 g of proline, 1.5 g of sodium carbonate, and 2 g of polyethylene glycol 400, add them into a 250 ml reaction flask, add 80 ml of purified water, and stir to clarify the system.
[0041] Weighed 21.8 g of methaquine and 11.8 g of benzaldehyde respectively, added them to the above catalytic system, heated to 25° C. for 5 hours, HPLC detected that the methaquine was completely reacted, cooled, and suction filtered to obtain the crude quinocetone.
[0042] Add 80 ml of methanol to the crude quinocetone, stir for 1 hour, filter with suction, and dry in vacuo to obtain 28.6 g of the product with a yield of 93% and a purity of 99.2%.
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