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Composition capable of preventing and treating acute rhinitis, chronic rhinitis and nasosinusitis

A technology for acute and chronic rhinitis and a composition, applied in the field of medicine, can solve problems such as the effect of curative effect, and achieve the effect of strong anti-inflammatory effect and strong mucosal repairing effect

Inactive Publication Date: 2019-07-16
江苏金叶子生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Above-mentioned existing various rhinitis treatment medicines all have curative effect to rhinitis to a certain extent, but there are some deficiencies, as general oral medicine tablet, pill need to go through the circulation of the whole body, the medicine amount that reaches nasal part is less, and The curative effect is affected to a certain extent; borneol camphor tree CirmamonunCamphora is not only a precious and rare medicinal material, but also a high-grade spice, or an important chemical raw material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: the preparation of the Chinese medicine composition of preventing and treating chronic rhinitis, sinusitis

[0031] (1) Calculated by mass fraction, add borneol camphor essential oil 1.0% and curcumin 0.5%, add borneol camphor essential oil, curcumin, pure water, and preservatives, mix evenly, fill into bottles, cover and spray Pump to get spray form.

[0032] (2) Experiments on acute toxicity, local irritation and allergy, the results showed that the maximum dosage of the drug to rats after nasal administration was 3.0 g / kg, and the maximum dosage of intraperitoneal administration to mice was 30.0 g / kg. g / kg, no toxic reaction and death were observed in a short period of time; in the local irritation test, the animals were generally in good condition, and no systemic reaction or even death occurred. Examination revealed that the mucous membranes of the respiratory tract, such as the nose, throat, trachea, and bronchi, had no damage and infiltration of a ...

Embodiment 2

[0038] Embodiment 2: the preparation of the Chinese medicine composition of preventing and treating chronic rhinitis, sinusitis

[0039] (1) Calculated by mass fraction, add 1.0% borneol camphor essential oil and 0.3% curcumin, add pure water and preservatives, mix evenly, fill into bottles, and cover with a spray pump to obtain a spray formulation.

[0040] (2) Experiments on acute toxicity, local irritation and allergy, the results showed that the maximum dosage of the drug to rats after nasal administration was 3.0 g / kg, and the maximum dosage of intraperitoneal administration to mice was 30.0 g / kg. g / kg, no toxic reaction and death were observed in a short period of time; in the local irritation test, the animals were generally in good condition, and no systemic reaction or even death occurred. Examination revealed that the mucous membranes of the respiratory tract, such as the nose, throat, trachea, and bronchi, had no damage and infiltration of a large number of inflamma...

Embodiment 3

[0045] Embodiment 3: the preparation of the Chinese medicine composition of preventing and treating chronic rhinitis, sinusitis

[0046] (1) Calculated by mass fraction, add 1.0% borneol camphor essential oil and 0.1% curcumin, add pure water and preservatives, mix evenly, fill into bottles, and cover with a spray pump to obtain a spray formulation.

[0047] (2) Experiments on acute toxicity, local irritation and allergy, the results showed that the maximum dosage of the drug to rats after nasal administration was 3.0 g / kg, and the maximum dosage of intraperitoneal administration to mice was 30.0 g / kg. g / kg, no toxic reaction and death were observed in a short period of time; in the local irritation test, the animals were generally in good condition, and no systemic reaction or even death occurred. Examination revealed that the mucous membranes of the respiratory tract, such as the nose, throat, trachea, and bronchi, had no damage and infiltration of a large number of inflammato...

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PUM

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Abstract

The invention discloses a composition capable of preventing and treating acute rhinitis, chronic rhinitis and nasosinusitis, and belongs to the field of medicines. Cinnamomum camphora essential oil and curcumin are combined, a pressurized spray, a nasal drop and other pharmaceutics preparation formulations for preventing and treating acute rhinitis, chronic rhinitis, allergic rhinitis and nasosinusitis can be prepared. Through clinical experiment, the composition has obvious preventing and treating effects on the acute rhinitis, the chronic rhinitis, the allergic rhinitis and the nasosinusitis, and can repair nasal mucosa tissue impaired due to inflammation, and a patient using the composition cannot produce any maladaptation reactions.

Description

technical field [0001] The invention relates to a composition for preventing and treating acute and chronic rhinitis and sinusitis, which belongs to the field of medicine. Background technique [0002] Acute and chronic rhinitis, allergic rhinitis, and sinusitis are common diseases with a high incidence rate. In the early stage of acute rhinitis, the nasal mucosa is catarrhal inflammation, mucosal blood vessels are dilated, congested, swollen, and glandular secretion is vigorous. The cells infiltrate, the secretion increases, it is mucus, and soon becomes purulent, which weakens the function of the cilia, swells the sinus, and obstructs the drainage. In the acute inflammation stage, if the anti-inflammatory drugs are used in time, the inflammation can subside, the drainage can be smooth and the whole recovery can be achieved. In patients with chronic rhinitis and sinusitis, the deep arteries of the nasal mucosa are in a state of chronic expansion and lose their contraction ...

Claims

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Application Information

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IPC IPC(8): A61K36/54A61K31/12A61K36/575A61K9/12A61P11/02A61P37/08
CPCA61K9/0043A61K9/12A61K31/12A61K36/54A61K36/575A61K2300/00
Inventor 陈建伟陆继好
Owner 江苏金叶子生物科技有限公司
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