Glutathione functionalized graphene oxide/gold nanorod composite material and its preparation method and application

A technology of gold nanorods and glutathione, which is applied in chemical instruments and methods, chemical/physical processes, and other chemical processes. problem, to achieve the effect of good adsorption performance

Active Publication Date: 2021-10-15
CHINA PHARM UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Technical problem to be solved: the purpose of the present invention is to solve the technical problem that graphene oxide is prone to agglomeration and difficult to disperse after being adsorbed as a solid phase extraction material, which is not conducive to the effective adsorption and elution of the sample to be tested. Glutathione functionalized graphene oxide / gold nanorod composites (GO / GNRs-GSH), prepared by loading gold nanorods onto graphene oxide and modifying the surface of gold nanorods with sulfhydryl groups contained in glutathione Obtained, this composite material is used as the adsorbent of novel solid phase extraction, can carry out adsorption separation to the ciprofloxacin in the solution and carry out trace analysis

Method used

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  • Glutathione functionalized graphene oxide/gold nanorod composite material and its preparation method and application
  • Glutathione functionalized graphene oxide/gold nanorod composite material and its preparation method and application
  • Glutathione functionalized graphene oxide/gold nanorod composite material and its preparation method and application

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Experimental program
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Embodiment 1

[0032] Preparation of a glutathione-functionalized graphene oxide / gold nanorod composite (GO / GNRs-GSH)

[0033] The preparation method is as follows:

[0034] Step 1, pre-take 1.0 g of graphene oxide and add it to 20 mL of water for ultrasonic dispersion for 2 hours to obtain a graphene oxide dispersion for use.

[0035] Step 2, the HAuCl 4 4H 2 O (0.50mmol L -1 ,5.0mL) with CTAB (0.20mol L -1 , 10.0 mL) were mixed, and freshly prepared ice-cold NaBH 4 (0.01mol L -1 ,600μL), and incubated at 25°C for 30min to prepare the seed solution.

[0036] Step 3, CTAB (0.02mol L -1 ,50mL) and HAuCl 4 4H 2 O (24mmol L -1 ,3.12mL) to mix, add AgNO 3 (4.0mmol L -1 ,2.8mL) and ascorbic acid (0.08mol L -1 , 1.25 mL) to prepare growth solution.

[0037]Step 4, the graphene oxide dispersion liquid (50mg mL of 20mL -1 ) into the growth solution. Finally 1 mL of the seed solution was added to the growth solution and kept overnight at 28 °C. The final solution was purified by thre...

Embodiment 2

[0042] Static adsorption experiment

[0043] Preparation (3.0, 4.0, 5.0, 6.0, 7.0, 8.0mg / L -1 ) a series of different concentrations of ciprofloxacin standard solution, the absorbance A value of each sample is measured successively, and the curve y=0.0961x-0.0036 is obtained, R2=0.9985, as can be seen the linear relationship between the concentration of ciprofloxacin standard solution and the absorbance Good relationship.

[0044] In subsequent experiments, the formula for calculating the adsorption rate is as follows:

[0045] Adsorption rate (%) = (c 0 –c e ) / c 0 ×100%

[0046] In the formula, c 0 and c e Represents the concentration of ciprofloxacin solution at the initial adsorption and adsorption equilibrium.

Embodiment 3

[0048] Adsorption effect of GO / GNRs-GSH adsorbent on ciprofloxacin at different acidity

[0049] Prepare a series of ciprofloxacin standard solutions (5.0mg L -1 ) in a 25mL Erlenmeyer flask, and then accurately weighed several 10.0mg GO / GNRs-GSH, and added them to ciprofloxacin standard solutions with different pHs, and put them into a constant temperature shaker in a water bath after being fully mixed. Shake for 30min. The experimental results are as figure 1 , the pH value is in the range of 2.0 to 6.0, the adsorption efficiency of GO / GNRs-GSH to ciprofloxacin increases with the increase of pH value; the quantitative adsorption (>95%) can be achieved at pH=7.0; When the pH of the solution was between 7.0 and 10.0, GO / GNRs-GSH achieved quantitative adsorption of ciprofloxacin.

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Abstract

The invention discloses a glutathione functionalized graphene oxide / gold nanorod composite material, a preparation method thereof and an application in ciprofloxacin adsorption and separation. Au nanorods were loaded on graphene oxide via a seed-mediated method, and finally, the graphene oxide / gold nanorods composite was modified with reduced glutathione to successfully synthesize glutathione-functionalized oxidized Graphene / gold nanorod composites. The maximum adsorption capacity of the glutathione functionalized graphene oxide / gold nanorod composite material of the present invention is higher than the adsorption capacity of reported graphene oxide, and can achieve quantitative adsorption in a short time, with good adsorption performance The maximum adsorption capacity of profloxacin is 476.2 mg g ‑1 .

Description

technical field [0001] The invention belongs to the technical field of antibiotic residue analysis, and specifically relates to a glutathione functionalized graphene oxide / gold nanorod composite material, a preparation method thereof, and an application in ciprofloxacin adsorption and separation. Background technique [0002] In recent years, with the rapid development of nanoscience and technology, more and more nanomaterials are emerging. The discovery and synthesis of carbon nanomaterials have also aroused a research boom of researchers worldwide. Researchers first prepared graphene oxide (Graphene oxide, GO) by chemical oxidation and exfoliation of graphite powder. Compared with graphene, graphene oxide has a large number of active oxygen-containing functional groups on the surface of a single carbon atomic layer. It has superior hydrophilicity and dispersibility in water. In addition, graphene oxide has a larger specific surface area. The two most impressive characteris...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/22B01D15/08
CPCB01D15/08B01J20/0233B01J20/20B01J20/22B01J2220/46
Inventor 李瑞军王娇何正豪张瑞恬杨志远张鑫
Owner CHINA PHARM UNIV
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