Purpose of transition metal-chelated chlorophyll derivative for improving microcirculation disorder

A microcirculation disorder and transition metal technology, applied in the field of medicine, can solve problems such as easy stomach discomfort, limited users, obvious toxic and side effects, etc., and achieve prevention and improvement of microcirculation disorder, safety of the applicable population, and simple process Effect

Active Publication Date: 2019-08-06
武汉联合药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, even if only for the treatment of specific parts, the efficacy of existing drugs also needs to be improved
Furthermore, the existing drugs not only have obvious toxic and side effects, but are likely to cause adverse reactions and side effects such as stomach

Method used

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  • Purpose of transition metal-chelated chlorophyll derivative for improving microcirculation disorder
  • Purpose of transition metal-chelated chlorophyll derivative for improving microcirculation disorder
  • Purpose of transition metal-chelated chlorophyll derivative for improving microcirculation disorder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Example 1 The protective effect of sodium copper chlorophyllin on cerebral acute microcirculation disturbance

[0069] According to the above method, the content of sodium copper chlorophyllin is about 37.0%, and other chlorophyll derivatives are more than 60.0% based on disodium copper chlorophyllin, and its effect on acute microcirculation disorder of rabbit brain Tested and the results are as follows.

[0070] Table 1 Effect of sodium copper chlorophyllin on the change rate of rabbit brain microcirculation

[0071]

[0072] Note: Compared with the negative control group: *: P<0.05, **: P<0.01

[0073] Table 1 shows that compared with the negative control group, the change rate of blood perfusion (PU) and exercise blood cell velocity (V) in the high-dose sodium copper chlorophyllin group was significantly reduced (P<0.01), and the high dose sodium copper chlorophyllin, The other evaluation indexes in the middle dose group showed a downward trend, which indicate...

Embodiment 2

[0074] Example 2 The protective effect of sodium copper chlorophyllin on muscle acute microcirculation disturbance

[0075] According to the above method, the content of sodium copper chlorophyllin is about 37.0%, and other chlorophyll derivatives are more than 60.0% based on disodium copper chlorophyllin. The effect on acute microcirculation disorder of rabbit muscles Tested and the results are as follows.

[0076] Table 2 Effect of sodium copper chlorophyllin on the change rate of rabbit muscle microcirculation

[0077]

[0078] Note: Compared with the negative control group: *: P<0.05, **: P<0.01

[0079] Table 2 shows that, compared with the negative control group, the rate of change of blood perfusion (PU) and degree of blood cell aggregation (CMBC) in the high-dose sodium copper chlorophyllinate group were significantly reduced (P<0.01), and the rate of change of copper chlorophyllin The other assessment indexes in the high sodium and medium dose groups showed a d...

Embodiment 3

[0080] Example 3 The protective effect of sodium copper chlorophyllin on mesenteric acute microcirculation disorder

[0081]According to the above method, take the silkworm excrement extract whose content of sodium copper chlorophyllin is about 37.0%, and other chlorophyll derivatives are more than 60.0% based on disodium copper chlorophyllin. Tested and the results are as follows.

[0082] Table 3 Effect of sodium copper chlorophyllin on the change rate of rabbit mesentery microcirculation

[0083]

[0084]

[0085] Note: Compared with the negative control group: *: P<0.05, **: P<0.01

[0086] Table 3 shows that compared with the negative control group, the blood perfusion (PU), blood cell aggregation degree (CMBC) and exercise blood cell velocity (V) rate of change in the high-dose sodium copper chlorophyllinate group were all significantly reduced (P<0.01) , the evaluation indicators of the medium-dose sodium copper chlorophyllinate group showed a downward trend, ...

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Abstract

The present invention belongs to the field of a medicine and relates to the use of a transition metal-chelated chlorophyll derivative for improving microcirculation disorder, in particular the use ofthe transition metal-chelated chlorophyll derivative for preparation of a medicine for treatment and/or prevention of microcirculation disorder. The transition metal-chelated chlorophyll derivative ofthe present invention, such as a chlorophyll extract and a silkworm extract, has the good effect on improving microcirculation disorder. The transition metal-chelated chlorophyll derivative can alsocomprehensively prevent and improve the microcirculatory disorder by acting in a plurality of links. Moreover, the toxic and side effects of the transition metal-chelated chlorophyll derivative are improved, the transition metal-chelated chlorophyll derivative is suitable for a wide range of people and is safe, and can be applied to treat children, the elderly, pregnant women and lactating women.In addition, a preparation method of the transition metal-chelated chlorophyll derivative and the method for preparing the medicine are relatively simple, and the cost is effectively controlled.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the use of transition metal chelated chlorophyll derivatives for improving microcirculation disorders, especially the use of transition metal chelated chlorophyll derivatives in the preparation of medicines for treating and / or preventing microcirculation disorders. Background technique [0002] With the improvement of people's living standards, the improvement of diet structure, the change of lifestyle, and the influence of genetic factors, the incidence of microcirculation disorders is on the rise. The high prevalence and high recurrence rate are the main causes of microcirculation disorders. main feature. Microcirculation refers to the blood circulation in capillaries between arterioles and venules. It is the part of the cardiovascular system in direct contact with tissue cells. The basic function of microcirculation is to carry out metabolism and material exchange, which is an importan...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61K31/409A61K33/34A61P9/14
CPCA61K31/409A61K33/34A61K35/64
Inventor 刘朝胜余明森王根才周红晖吴瑜罗京付雯刘敏袁建新徐发新
Owner 武汉联合药业有限责任公司
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