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Preparation method for tramadol hydrochloride dispersible tablet

A technology of tramadol hydrochloride and dispersible tablets, applied in the field of medicine, can solve the problems of influence effect, short dispersion period, short drug effect period, etc., and achieve the effects of fast onset of action, improved effect, and long analgesic effect.

Inactive Publication Date: 2019-08-09
安徽金太阳生化药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing Tramadol Hydrochloride Dispersible Tablets have a short dispersion cycle and a short drug effect cycle, which affects the performance of the effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] A preparation method of tramadol hydrochloride dispersible tablet, comprising the following steps:

[0015] A tramadol hydrochloride dispersible tablet, in order to prepare 100,000 tramadol hydrochloride dispersible tablets, the raw material components of the tramadol hydrochloride dispersible tablet are tramadol hydrochloride 5kg, pregelatinized starch 2.5kg, microcrystalline fiber Su 12.5kg, crospovidone 7.5kg, calcium carbonate 1.5kg, magnesium stearate 0.2kg.

[0016] (1), the tramadol hydrochloride of 2.5kg and the pregelatinized starch of 1.2kg are mixed uniformly, put into 100-200 mesh pulverizer and pulverize again, make the two fully interactively mix;

[0017] (2), put the step (1) material into the three-dimensional motion mixer, add remaining tramadol hydrochloride, crospovidone, calcium carbonate and mix for 5-15 minutes, mix well;

[0018] (3), in the three-dimensional motion mixer, add microcrystalline cellulose, magnesium stearate, remaining pregelatini...

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PUM

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Abstract

The invention provides a preparation method for a tramadol hydrochloride dispersible tablet. The tramadol hydrochloride dispersible tablet is prepared from tramadol hydrochloride of the effective treatment dosage, pregelatinized starch, microcrystalline cellulose, polyvinylpolypyrrolidone, calcium carbonate and magnesium stearate. After partial tramadol hydrochloride and partial pregelatinized starch are adopted for sufficient mixing in the earlier stage, smashing is conducted, so that the mixture is uniformly mixed sufficiently, and the dispersion effect of the tramadol hydrochloride is improved; the quick effect is ensured. Then, the rest of tramadol hydrochloride, the polyvinylpolypyrrolidone and the calcium carbonate are mixed sufficiently, the adhesive characteristic of the polyvinylpolypyrrolidone is utilized, so that the partial tramadol hydrochloride is slowly released, and analgesic effect time is prolonged.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a preparation method of tramadol hydrochloride dispersible tablets. Background technique [0002] Dispersible tablets are tablets that disintegrate rapidly and disperse uniformly in water. Compared with solid preparations such as ordinary tablets and capsules, dispersible tablets have the characteristics of convenient administration, rapid disintegration, rapid absorption and high bioavailability. Tramadol Hydrochloride Dispersible Tablets are mainly used clinically to reduce various acute and chronic pains, such as postoperative pain, labor pain, pain caused by diagnostic exploration, traumatic pain, etc., and as the first echelon drug for the treatment of cancer pain. It has a rapid onset of action, does not inhibit the respiratory and cardiovascular systems at therapeutic doses, and has low addiction, tolerance and dependence. The existing tramadol hydrochloride dispersib...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/38A61K47/36A61K47/32A61K47/02A61K47/12A61K31/137A61P29/00
CPCA61K9/2009A61K9/2013A61K9/2027A61K9/2054A61K9/2059A61K31/137A61P29/00
Inventor 陈永恒徐三能强泽明
Owner 安徽金太阳生化药业有限公司
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