Degradable regenerative medical material for promoting tissue in-situ regeneration and preparation method of medical material

A medical material, in-situ regeneration technology, applied in medical science, prosthesis, etc., can solve the high price of imported products, the growing demand for regenerative medicine medical devices, and the inability to use regenerative medical medical devices for low- and middle-income patients. problem, to achieve the effect of tissue in-situ repair function, pH stability, and huge specific surface area

Active Publication Date: 2019-08-09
BEIJING BEST LIFE REGENERATIVE MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In 2016 alone, the annual sales of medical devices used in my country's regenerative medicine were about 120 billion U.S. dollars, with an annual growth rate of more than 25%. Most of them need to be directly imported or prepared after importing regenerative medicine materials. The industry has gradually formed a monopoly situation; on the one hand, the huge demand for regenerative medicine medical devices in my country continues to grow; on the other hand, due to the core materials for manufacturing medical devices being monopolized by foreign countries, the prices of a large number of imported products remain high, and a large number of low-to-medium Income sick groups cannot use high-quality regenerative medicine medical devices, resulting in huge contradictions

Method used

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  • Degradable regenerative medical material for promoting tissue in-situ regeneration and preparation method of medical material
  • Degradable regenerative medical material for promoting tissue in-situ regeneration and preparation method of medical material
  • Degradable regenerative medical material for promoting tissue in-situ regeneration and preparation method of medical material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] A degradable regenerative medical material with a three-dimensional network structure that promotes tissue regeneration in situ. According to the mole fraction, the raw materials include:

[0050]

[0051] In this example, the preparation method of the degradable regenerative medical material having a three-dimensional network structure and promoting tissue regeneration in situ is as follows:

[0052] First prepare the mixed sol: add 110 parts of water to the reactor, add 0.2 parts of catalyst and stir evenly, then add 78 parts of silicate and 7 parts of phosphate for pre-hydrolysis reaction, and hydrolyze until the mixed solution becomes transparent and clear Add 22 parts of soluble metal salts and stir until completely dissolved to obtain a mixed sol;

[0053] Then, disperse 0.5 part of thickener with 2 parts of alcohol solvent and add it to the mixed sol, stir until it is completely swollen and dissolved, then add 1 part of foam stabilizer and 5 parts of foam fixa...

Embodiment 2

[0068] A degradable regenerative medical material with a three-dimensional network structure that promotes tissue regeneration in situ, comprising:

[0069]

[0070]

[0071] In this example, the preparation method of the degradable regenerative medical material having a three-dimensional network structure and promoting tissue regeneration in situ is as follows:

[0072] First prepare the mixed sol: add 150 parts of water to the reactor, add 0.4 parts of catalyst and stir evenly, then add 60 parts of silicate and 15 parts of phosphate for pre-hydrolysis reaction, and hydrolyze until the mixed solution becomes transparent and clear Add 30 parts of soluble metal salt and stir until completely dissolved to obtain a mixed sol;

[0073] Then, disperse 1.5 parts of thickener with 3.5 parts of alcohol and add it to the mixed sol, stir until it is completely swollen and dissolved, then add 2 parts of foam stabilizer and 7.5 parts of foam fixative, stir well and then age at room ...

Embodiment 3

[0088] A degradable regenerative medical material with a three-dimensional network structure that promotes tissue regeneration in situ, comprising:

[0089]

[0090] In this example, the preparation method of the degradable regenerative medical material having a three-dimensional network structure and promoting tissue regeneration in situ is as follows:

[0091] First prepare the mixed sol: add 150 parts of water to the reactor, add 0.4 parts of the catalyst and stir evenly, then add 60 parts of silicate and 15 parts of phosphoric acid esters for pre-hydrolysis reaction, hydrolyze until the mixed solution becomes transparent and clear, then add 30 parts of soluble metal salts were stirred until completely dissolved to obtain a mixed sol;

[0092] Then, disperse 2.5 parts of thickener with 5 parts of alcohol and add it to the mixed sol, stir until it is completely swollen and dissolved, then add 3 parts of foam stabilizer and 10 parts of foam fixative, stir well and then age...

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Abstract

The invention discloses a degradable regenerative medical material for promoting tissue in-situ regeneration and a preparation method of the medical material. The degradable regenerative medical material is formed by Si, P, O, and metallic elements containing calcium through chemical bonding, and is of a regular three-dimensional net structure formed by taking a material with a nano-scale mesoporous structure as a framework, and pores and micron-scale macropores communicated with the pores are uniformly formed in the regular three-dimensional net structure. The preparation method of the degradable regenerative medical material comprises the steps of preparation of mixed gel, foaming and curing and calcination. The regenerative medical material has a huge specific surface area, powerful biological activity, high biological safety, has an effect of promoting cell proliferation, can induce rapid regeneration of own cells of injury tissue, and achieve an in-situ tissue repair function.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a degradable regenerative medical material capable of promoting tissue regeneration in situ and a preparation method thereof. Background technique [0002] Regenerative medicine is a cutting-edge interdisciplinary subject that comprehensively applies the principles and methods of life science, material science and clinical medicine to research and develop theoretical technologies for replacing, repairing, reconstructing or regenerating various tissues and organs of the human body. The treatment of congenital genetic defects and various tissue and organ injuries is a leap in the development of human medicine; it has become a new frontier in the field of medical biology, which has extremely important theoretical and practical significance and significance for the development of medical biology. Value; The development of regenerative medicine puts forward higher require...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/50A61L27/56A61L27/58
CPCA61L27/12A61L27/56A61L27/58A61L27/50A61L27/04A61L27/025A61L27/54A61L2300/412
Inventor 郭创洲胡方仇越秀于晓丽
Owner BEIJING BEST LIFE REGENERATIVE MEDICINE TECH CO LTD
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