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Extraction method of pseudo-ginseng polysaccharide

A technology of Panax notoginseng polysaccharide and extraction method, which is applied in the field of extraction of Panax notoginseng polysaccharide, can solve the problems of low extraction rate and high impurity content of Panax notoginseng polysaccharide, and achieves the improvement of extraction rate, product quality and high absorption rate. Effect

Pending Publication Date: 2019-08-09
云南绿戎生物产业开发股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the deficiencies of the prior art, the present invention provides a method for extracting notoginseng polysaccharide with reliable performance, which solves the problems of low extraction rate of notoginseng polysaccharide and high impurity content in the existing extraction method, and can improve product quality

Method used

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  • Extraction method of pseudo-ginseng polysaccharide
  • Extraction method of pseudo-ginseng polysaccharide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 1000g of Panax notoginseng lump medicinal material, add 30% ethanol, then pour it into a wet micro-powder machine for pulverization, the pulverization time is 8min, then filter and collect the filtrate, the mass of the added ethanol solution is 8 times of that of Panax notoginseng. The collected filtrate is separated by a centrifuge to obtain a centrifuge; the centrifuge is passed through an automatic concentrator to shrink the volume to obtain an extract, and the extract is concentrated under reduced pressure to a Baume degree of 8-10°; after obtaining the extract Add purified water to dissolve it, then add trifluoromethanesulfonic acid with 4% mass of the mixture, and hydrolyze it in airtight at 90°C for 20min, recover trifluoromethanesulfonic acid under vacuum at 45-65°C to obtain crude polysaccharide extract; Cationic resin was added, washed with purified water, and combined to obtain eluates. The mass ratio of cationic resin to polysaccharide crude extract is ...

Embodiment 2

[0026] Take 1000g of Panax notoginseng block medicinal material, add 70% ethanol, then pour it into a wet micro-powder machine for pulverization, the pulverization time is 10min, then filter and collect the filtrate, the mass of the added ethanol solution is 10 times of that of Panax notoginseng. The collected filtrate is separated by a centrifuge to obtain a centrifuge; the centrifuge is passed through an automatic concentrator to shrink the volume to obtain an extract, and the extract is concentrated under reduced pressure to a Baume degree of 9°; in the obtained extract, add Dissolve in purified water, then add trifluoromethanesulfonic acid with 5% mass of the mixture, and hydrolyze in airtight at 90-95°C for 25 minutes, recover trifluoromethanesulfonic acid under vacuum at 45-65°C to obtain crude polysaccharide extract; Cationic resin was added, washed with purified water, and combined to obtain eluates. The mass ratio of cationic resin to polysaccharide crude extract is 3...

Embodiment 3

[0028] Take 1000g of Panax notoginseng block medicinal material, add 90% ethanol, then pour it into a wet micro-powder machine for crushing, the pulverization time is 30min, then filter and collect the filtrate; the mass of the added ethanol solution is 12 times of that of Panax notoginseng. The collected filtrate is separated by a centrifuge to obtain a centrifuge; the centrifuge is passed through an automatic concentrator to shrink the volume to obtain an extract, and the extract is concentrated under reduced pressure to a Baume degree of 10°; in the obtained extract, add Dissolve in purified water, then add trifluoromethanesulfonic acid with 6% mass of the mixture, and after airtight hydrolysis at 90-95°C for 30 minutes, vacuum recover trifluoromethanesulfonic acid at 45-65°C to obtain crude polysaccharide extract; Cationic resin was added, washed with purified water, and combined to obtain eluates. The mass ratio of cationic resin to polysaccharide crude extract is 4:1. Wh...

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Abstract

The invention relates to the technical field of drug preparation, in particular to an extraction method of pseudo-ginseng polysaccharide. The method comprises the following steps of A, extraction, wherein herbal pseudo-ginseng blocks are obtained, ethanol is added, the mixture is poured into a wet micro-mill for smashing, and a filtrate is collected; B, centrifuging, wherein the collected filtrateis separated by a centrifuge; C, vacuum concentration, wherein an extractive solution is obtained; D, refining, wherein the extractive solution is added into purified water for dissolving, and then trifluoromethanesulfonic acid is added to obtain a crude polysaccharide extract; E, chromatography, wherein the crude polysaccharide extract is added into cationic resin, purified water is adopted forwashing, and all liquids are combined to prepare an eluent; F, purification; G, concentration, wherein a pseudo-ginseng polysaccharide solution is poured into n-butanol under reduced pressure first and subjected to standing after stirring, and a pseudo-ginseng polysaccharide crystal precipitate is prepared after layering; H, vacuum drying, wherein pseudo-ginseng polysaccharide is prepared throughvacuum drying. The method solves the problems of low pseudo-ginseng polysaccharide extraction rate and high impurity content in existing extraction methods and can improve the product quality.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a method for extracting Panax notoginseng polysaccharide. Background technique [0002] Panax notoginseng, also known as Jinbuhuan, is an Araliaceae plant whose root is used as a medicinal part. Panax notoginseng is mainly produced in Wenshan, Yunnan, my country and other places. Panax notoginseng polysaccharide is a heteropolysaccharide or its compound extracted from Panax notoginseng with multiple biological activities and complex structure. A large number of studies have proved that Panax notoginseng polysaccharide has various effects such as anti-tumor, hypoglycemic, anti-oxidation, and enhancing immunity. At present, the extraction method of Panax notoginseng polysaccharides is generally prepared by solvent reflux method. This method often has the problems of low content of Panax notoginseng polysaccharides in the final extract, long production cycle, and incre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00
CPCC08B37/0003
Inventor 陈穗云李承玄闫春丽张志鹏汪家乐李秀军
Owner 云南绿戎生物产业开发股份有限公司
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