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Dual-mode optical tracing drug nano-carrier and preparation method thereof

A nano-drug carrier, dual-mode technology, used in luminescence/biological dyeing preparations, drug combinations, drug delivery, etc., can solve problems such as unfavorable application, high toxicity, and difficulty in drug tracking, achieving low toxicity and good stability. , SERS enhancement effect is good

Inactive Publication Date: 2019-08-16
JINLING INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Usually used for optical tracking of nano-drug carriers is mainly based on fluorescent signals. Taking quantum dots as an example, marking quantum dots on drug carriers can realize fluorescent tracking of carriers, but the raw materials used in the synthesis of quantum dots are generally heavy metals. , very toxic, not conducive to in vivo applications, and it is also difficult to trace drugs for drugs without fluorescent properties

Method used

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  • Dual-mode optical tracing drug nano-carrier and preparation method thereof
  • Dual-mode optical tracing drug nano-carrier and preparation method thereof
  • Dual-mode optical tracing drug nano-carrier and preparation method thereof

Examples

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Embodiment 1

[0035] Example 1 uses Au@Ag nanoparticles as the SERS substrate, carbon nanotubes with large inner diameter as the carrier, 4MBA as the SERS marker, and FITC as the fluorescent molecule to prepare dual-mode optical tracer nano drug carrier particles; Example 2 uses Au@Ag nanoparticles were used as SERS substrate, carbon nanotubes with large inner diameter were used as carriers, and 6-TG and DOX were used as antitumor drugs to prepare dual-mode optically tracked nano drug carrier particles.

[0036] Example 1

[0037] Using carbon nanotubes with large inner diameters as carriers, Au@Ag nanoparticles as SERS substrates, 4MBA as SERS markers, and FITC as fluorescent molecules to prepare dual-mode optical tracer nano drug carrier particles, the method includes the following steps:

[0038] (1) To prepare water-soluble large-diameter carbon nanotubes, the carbon nanotubes are first modified by shearing and shortening. Take 10 mg of large-inner-diameter thin-walled multi-walled car...

Embodiment 2

[0047] Preparation of optical tracer drug carriers with Au@Ag core-shell structure nanomaterials modified large inner diameter carbon nanotubes as carriers, doxorubicin hydrochloride (DOX) molecules and 6-mercaptoguanine (6-TG) molecules as drug models, The method comprises the steps of:

[0048] (1) To prepare water-soluble large-diameter carbon nanotubes, the carbon nanotubes are first modified by shearing and shortening. Take 10 mg of large-inner-diameter thin-walled multi-walled carbon nanotubes (LNCNTs) prepared by catalytic cracking of acetylene with a nickel-based catalyst. The inner diameter of LNCNTs is generally greater than 20 nm, the outer diameter is 30-60 nm, and the length is 1-10 μm. Mix LNCNTs and 50 mL of concentrated sulfuric acid-concentrated nitric acid mixture (molar ratio 3:1) into a glass flask, and place the flask in an ultrasonic cleaner with a water temperature of 50° for 12 hours, and then wash it with a large amount of deionized water Dilute the m...

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Abstract

The invention discloses a dual-mode optical tracing drug nano-carrier and a preparation method thereof. The dual-mode optical tracing drug nano-carrier is composed of a core layer, a wrapping layer and a coating layer, wherein the wrapping layer is a hollow carbon nanotube, the core layer is arranged in the inner cavity of the wrapping layer, and the coating layer is arranged on the outer wall ofthe wrapping layer; the core layer is indole with temperature phase change characteristics; the coating player is composed of gold core-silver shell nanoparticles absorbing SERS (surface enhanced Raman scattering) markers and a fluorescence probe; a drug model I is packaged in the inner cavity of the wrapping layer through the indole, a drug model II is loaded onto the outer wall of the wrapping layer through the chemical characteristics of the hollow carbon nanotube, so that temperature-control release of the drug model I and pH-controlled release of the drug model II can be achieved. By means of the composite structure of the carbon nanotube and the metal nanoparticles, the dual-mode optical tracing drug nano-carrier achieves synergistic delivery and controlled release of multiple drugsas well as dual-mode optical tracing with SERS and fluorescence.

Description

technical field [0001] The present invention relates to nanomaterial preparation technology, in particular to a novel dual-mode optical tracer nano-medicine carrier and its preparation method. It is integrated with the carbon nanotube carrier structure, and has dual optical tracking capabilities of fluorescence and SERS and multi-drug transport functions. Background technique [0002] In recent years, with the rapid development of nanomaterial preparation and characterization technologies, multifunctional nano-drug carriers based on nanomaterials have been widely used in the fields of biodiagnosis and biomedicine due to their unique drug delivery properties, small size, and targeting and tracking. It has great application prospect. [0003] Among the optical tracer technologies, the fluorescence detection technology is fast and simple, and is a commonly used biological detection method, which is widely used in the fields of biosensing, drug development, tumor diagnosis and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K41/00A61K47/22A61K47/52A61K47/69A61K31/704A61K31/522A61P35/00
CPCA61K31/522A61K31/704A61K41/0052A61K47/22A61K49/0013A61K49/0043A61K49/005A61K49/0093A61K47/52A61K47/6925A61P35/00A61K2300/00
Inventor 陈鹏张玲玲沈令斌代倩孟超
Owner JINLING INST OF TECH