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Bottom-layer blood platelet factor patch and preparation method of sPL blood platelet factor gel patch membrane

A platelet factor and underlying technology, which is applied in blood diseases, pharmaceutical formulations, inactive components of polymer compounds, etc., can solve the problems of uneven composition, uneven thickness, and indeterminate shape of platelet factor film, which is convenient for operation and emergency. The effect of using and reducing the content of key factors

Pending Publication Date: 2019-09-17
天晴干细胞股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the problems of platelet factor patch with indeterminate shape, uneven thickness and uneven composition, and to provide a preparation method of bottom platelet factor patch and sPL platelet factor gel patch

Method used

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  • Bottom-layer blood platelet factor patch and preparation method of sPL blood platelet factor gel patch membrane
  • Bottom-layer blood platelet factor patch and preparation method of sPL blood platelet factor gel patch membrane
  • Bottom-layer blood platelet factor patch and preparation method of sPL blood platelet factor gel patch membrane

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specific Embodiment approach 1

[0031] Embodiment 1: In this embodiment, a bottom-layer platelet factor patch includes a bottom-layer lining film 1 and an upper-layer covering film 2, and the upper-layer covering film 2 covers the bottom-layer lining film 1; the middle area of ​​the bottom-layer lining film 1 is depressed downward to form platelets The factor bearing area 4, the platelet factor bearing area is provided with diversion ribs; the upper cover film 2 is provided with a liquid inlet 3, and the liquid inlet 3 is provided with a sealing cover 5; wherein the liquid inlet 3 is located in the platelet factor bearing area directly above the center.

specific Embodiment approach 2

[0032] Embodiment 2: This embodiment differs from Embodiment 1 in that: the liquid inlet 3 is threadedly connected to a pressure syringe with a sterile threaded port. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0033] Embodiment 3: This embodiment differs from Embodiment 1 or Embodiment 2 in that: the depth of the platelet factor bearing region 4 is 3 mm. Others are the same as in the first or second embodiment.

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Abstract

The invention discloses a bottom-layer blood platelet factor patch and a preparation method of a sPL blood platelet factor gel patch membrane. The bottom-layer blood platelet factor patch and the preparation method of the sPL blood platelet factor gel patch membrane aim at solving the problems that a blood platelet plasmagel product has to be prepared in situ, and a blood platelet factor patch membrane is variable in shape and uneven in thickness and component. The bottom-layer blood platelet factor patch comprises a bottom-layer lining membrane and an upper-layer cover membrane, the middle area of the bottom-layer lining membrane is sunken downward to form a blood platelet factor bearing area, and the blood platelet factor bearing area is coated with collagen and an activating agent; blood platelet factors quickly make contact with the collagen and the activating agent and are quickly and uniformly activated. The bottom-layer blood platelet factor patch and the preparation method of the sPL blood platelet factor gel patch membrane overcome the defects that the conventional blood platelet plasmagel product cannot achieve standardization and cannot be prepared in advance, through a conventional spray coating mode or a conventional mixing mode, the gel patch membrane is not shaped and is uneven in thickness and variable in shape, and gel is crumpled and shrunken. The bottom-layer blood platelet factor patch and the preparation method of the sPL blood platelet factor gel patch membrane are applied to the field of blood platelet factor gel patch membranes.

Description

technical field [0001] The invention relates to a preparation method of bottom platelet factor patch and sPL platelet factor gel patch. Background technique [0002] Mammalian blood is composed of 55% plasma and 45% blood cells, among which blood cells can be divided into three categories: red blood cells, white blood cells and platelets. Platelets account for less than 1% of blood cells. Under physiological conditions, they maintain the integrity of the vascular endothelium and participate in hemostasis and coagulation. When the body is traumatized, platelets initiate the coagulation mechanism and release coagulation factors and pro-vasoactive factors It plays an important regulatory role in early wound healing, thrombus formation, and tissue repair. [0003] The platelet count in normal blood is 100-300×10 9 per liter, when the platelets in the blood are too low, it is easy to bleed. Some diseases will be accompanied by thrombocytopenia, so transfusion of platelets can ...

Claims

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Application Information

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IPC IPC(8): A61K35/19A61K9/70A61K47/42A61P17/02A61P7/04
CPCA61K35/19A61K9/7007A61K47/42A61P17/02A61P7/04
Inventor 聂峰光张怡刘春香刘艳青
Owner 天晴干细胞股份有限公司
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