Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Heteropolyvanadate compound and preparation method thereof

A heteropolyvanadate compound and crystallization technology, which is applied in organic chemistry methods, chemical instruments and methods, compounds of Group 5/15 elements of the periodic table, etc., can solve difficult problems of drug resistance, side effects of chemotherapy drugs, Expensive and other issues

Active Publication Date: 2019-09-20
JILIN UNIV
View PDF5 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the clinical treatment of tumors mainly adopts surgery, radiotherapy, chemotherapy and other methods, but the side effects of chemotherapy drugs are relatively large; although targeted therapy drugs are sensitive, the problem of drug resistance is very difficult and expensive; the safety of immunotherapy is uncertain

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Heteropolyvanadate compound and preparation method thereof
  • Heteropolyvanadate compound and preparation method thereof
  • Heteropolyvanadate compound and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Preparation of a heteropolyvanadate compound

[0023] VCl 4 (20 mg, 0.104 mmol) and organic ligand 4,4,4-triazine-2,4,6-tribenzoic acid (abbreviated as: H 3 TATB, 25 mg, 0.057 mmol) was dissolved in 2 mL N,N-dimethylformamide (DMF) and 0.5 mL acetonitrile solution, stirred at room temperature for 30 minutes, and then transferred to a polytetrafluoroethylene reactor for crystallization at 130 °C for 48 hour, after the program was cooled to room temperature, the green crystals were isolated, washed with DMF, and dried at room temperature to obtain the target product (yield 69%, based on H 3 TATB); molecular formula [NH 2 (CH 3 ) 2 ] 12 [(V 5 o 9 Cl) 6 (TATB) 8 ].

Embodiment 2

[0024] Example 2 Structural Analysis and Basic Characterization of Compounds

[0025] Compound [NH 2 (CH 3 ) 2 ] 12 [(V 5 o 9 Cl) 6 (TATB) 8 ] crystallized in the cubic crystal system, the space group is Fm-3m ,Cell parameters a = b = c =40.0473(9)Å, α=β=γ=90°, V=64227(4)Å 3 . The compound is a nanomolecular cage structure with an octahedral configuration, and each vertex of the octahedron is composed of [V 5 o 9 Cl]-built pentanuclear vanadyl clusters, each vanadyl cluster is bridged by four TATB organic ligands through terminal oxygen, and each TATB organic ligand is bridged by three carboxyl groups to three [V 5 o 9 Cl] clusters, each nanomolecular cage consists of six [V 5 o 9 Cl] clusters are bridged by eight organic ligands, TATB, to form a nanomolecular cage with an octahedral configuration. The size of the nanomolecular cage is 3.2 nm. Adjacent nanomolecular cages form a cubic packing pattern in space, forming a three-dimensional supramolecular comp...

Embodiment 3

[0031] Example 3 In vitro experiments to detect the inhibitory effect of compounds on tumor cells

[0032] 1. Experimental materials

[0033] Tumor cells: SMMC-7721 (human liver cancer cells)

[0034] MCF-7 (human breast cancer cells)

[0035] A549 (human lung cancer cells)

[0036] HL-60 (human leukemia cells);

[0037]Culture medium: RPMI640 medium containing 10% calf serum (medium for culturing SMMC-7721 cells), DMEM medium containing 10% calf serum (medium for cultivating MCF-7 and A549 cells), containing 10% IMEM medium (medium for culturing HL-60 cells) with calf serum.

[0038] 2. Experimental method

[0039] Resuscitate the cells by conventional methods, and adjust the cell concentration to 4×10 4 Cells / ml (SMMC-7721 cells, MCF-7 cells), 8×104 cells / ml (A549 cells), 1.5×105 cells / ml (HL-60 cells); 96-well plate culture, add cell suspension to each well 100 μl was cultured at 37°C and 5% CO2 for 24 hours, and then the culture solution of the corresponding cells w...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a heteropolyvanadate compound which has a molecular formula [NH2(CH3)2]12[(V5O9Cl)6(TATB)8]. A preparation method comprises the following steps: dissolving VCl4 and 4,4,4-triazine-2,4,6-tribenzoic acid into 2ml of N,N-dimethyl formamide and 0.5mL of an acetonitrile solution, and carrying out stirring at room temperature; carrying out crystallization for 40-60 hours at 125-135 DEG C; reducing the temperature, separating a green crystal, carrying out washing, and carrying out room-temperature drying, so as to obtain the heteropolyvanadate compound. In-vitro experiment results show that median inhibitory concentrations of the salt upon cells SMMC-7721, MCF-7, A549 and HL-60 are respectively 0.67[mu] mol / L, 0.44[mu]mol / L, 0.48[mu]mol / L and 2.09[mu]mol / L; and in-vivo experiment results show that the salt is capable of reducing weights of tumors of Hep-A-22 liver cancer tumor-bearing mice.

Description

technical field [0001] The invention belongs to the technical field of chemical synthesis of drugs, and in particular relates to a heteropolyvanadate compound and a preparation method thereof. Background technique [0002] In recent years, the incidence of malignant tumors has been increasing year by year, while the age of onset has been decreasing, and the mortality rate is high, seriously endangering human health. According to statistics from the American Cancer Society in September 2018, there were 18.1 million new cancer cases and 9.6 million cancer deaths worldwide. At present, the clinical treatment of tumors mainly adopts surgery, radiotherapy, chemotherapy and other methods, but the side effects of chemotherapy drugs are relatively large; although targeted therapy drugs are sensitive, the problem of drug resistance is very difficult and expensive; the safety of immunotherapy is uncertain. If a cost-effective anti-tumor drug can be developed, it will be a boon for ca...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/00A61P35/00A61P35/02A61K31/555
CPCA61P35/00A61P35/02C07B2200/13C07F9/005
Inventor 李娟郑雁王新龙李金华赵尧李婉玲
Owner JILIN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com