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Biodegradable polyionenes

一种烯基、化合物的技术，应用在护理皮肤的制剂、含有效成分的医用配制品、化妆品等方向，能够解决高毒性等问题

Inactive Publication Date: 2019-09-27
AGENCY FOR SCI TECH & RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been found that although the use of long alkyl chains in polymers enhances antimicrobial activity, it also causes correspondingly high toxicity

Method used

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  • Biodegradable polyionenes
  • Biodegradable polyionenes
  • Biodegradable polyionenes

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Embodiment Construction

[0158] The present disclosure relates to novel A 2 type monomers, biodegradable cationic polyionene, and Gemini surfactants containing biodegradable amine linking groups, which were synthesized by addition chemistry using these monomers and commercially available tertiary amine-based reagents, and their resistance Microbial properties. These materials can have extremely low minimum inhibitory concentration (MIC) values, broad-spectrum activity against clinically relevant pathogens, and simultaneously possess tunable selectivity.

[0159] These materials may have extremely low MIC values, broad-spectrum action and tunable selectivity against clinically relevant pathogens (HC 50 ). The compounds, compositions and synthetic methods can provide inexpensive biodegradable antimicrobial materials for personal care and biomedical applications through a step-efficient synthetic route.

[0160] Compounds of the following formula (I), (Ia) or (Ib) are provided:

[0161]

[0162] i...

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Abstract

Synthesis of polyionenes with built-in degradable linkers through addition polymerization of a novel class of degradable A2-type monomers (d-A2), and their use as antimicrobial agents are disclosed. A library of biodegradable polyionenes and Gemini-surfactants made from d-A2 monomers are also disclosed. These materials have potent and broad spectrum of antimicrobial activity with high selectivity over mammalian cells.

Description

technical field [0001] The present invention relates to novel A 2 type monomers, biodegradable cationic polyionene (polyionene), and Gemini surfactants containing biodegradable linking groups, which were synthesized by addition chemistry using these monomers and commercially available tertiary amine-based reagents , and its antimicrobial properties. Background technique [0002] Triclosan is the most widely used antimicrobial agent in personal care products such as cosmetics, deodorants and soaps. While it is effective against Gram-positive bacteria, it has low activity against Gram-negative bacteria and molds due to the development of resistance to triclosan by such Gram-negative bacteria. In addition, like many antimicrobial agents used in personal care products, triclosan has a long-lasting antimicrobial function in the environment after application, such as causing harm to aquatic organisms. Because of these concerns, the FDA banned 19 antimicrobials, including triclo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G73/02C08L79/02A61K31/785A61P31/04A61Q17/00
CPCA61K31/785C08L79/02A61P31/04A61Q17/005A61K8/84A61Q19/10A61K31/765C08G69/44C08G73/0293C08K5/0058
Inventor 杨义燕S·文卡塔拉曼陈邦钧
Owner AGENCY FOR SCI TECH & RES