Niraparib granules with high utilization efficiency and preparation method thereof

Abstract

The invention discloses niraparib granules with a high utilization efficiency and a preparation method thereof, and belongs to the technical field of medicine production. The components of the niraparib granules include niraparib, glucose, vitamin C and a carboxylesterase inhibitor. A granule packaging machine adopted in the preparation method comprises a storage bin and a transparent upper discharge pipe, wherein the transparent upper discharge pipe penetrates through the storage bin, the two sides of the upper discharge pipe are provided with an infrared emitter and an infrared receiver respectively, the infrared emitter and the infrared receiver are capable of lifting and lowering, a turntable is arranged below the upper discharge pipe, a curved through hole is formed in the turntable,a retractable stop block with a proximity switch is arranged on one side of the turntable, and a curved groove is formed in the turntable. By adopting the niraparib granules, the amount of niraparib discharged along with excretion can be reduced, and the pharmacodynamic effect of the niraparib can be maintained; valve-related components of the granule packaging machine adopted in the preparation process of the niraparib granules have longer service life, it can be ensured that the amount of the material discharged each time is sufficient, the remaining granules with a remaining amount less than a set value are remained in the upper discharge pipe, and the application is convenient.

Description

technical field [0001] The invention relates to the technical field of medicine production, in particular to a highly utilized niraparib granule and a preparation method thereof. Background technique [0002] Niraparib (Niraparib) is an oral poly ADP-ribose polymerase (PARP) inhibitor, mainly targeting cancers with BRCA1 / 2 gene mutations, developed for ovarian cancer and breast cancer. Niraparib inhibits the repair of cells to DNA damage. For cancer cells with BRCA gene mutations, if PARP activity is further inhibited, a large amount of DNA damage will be generated when these cells divide, leading to the death of cancer cells. The chemical name of Nirapa is 2-[4-((3S)-3-piperidinyl)phenyl]-2H-indazole-7-carboxamide, which was developed by Merck and later transferred to American Biotechnology The company Tesaro, which announced the phase III clinical data of niraparib for advanced ovarian cancer, showed extremely good efficacy. [0003] According to research, after a single...

AI Technical Summary

Problems solved by technology

Granules usually need to be packaged in separate bags with a granule packaging machine during preparation, while the existing impact packaging machines usually use the frequent opening and closing of the electric control valve at the discharge port to realize quantitative feeding, and the service life of the electric control valve is short ; The existing granule packaging machine immediately closes the electronically controlled valve when it detects that the remaining amount of granule is less than the preset value. The amount required for one bag, if you don’t want to waste the granule, you need to collect this part of the granule and return it to the storage box, which is inconvenient to use

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