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50results about How to "Increase the amount of binding" patented technology
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Boron and nitrogen co-doping chitosan-base activated carbon and method for preparing same
ActiveCN102951637AHigh nitrogen contentHigh specific capacitanceCarbon compoundsProtonationStrong acids
The invention provides a boron and nitrogen co-doping activated carbon which is prepared through utilizing biomass. The boron and nitrogen co-doping chitosan-base activated carbon takes chitosan and boric acid as raw materials, wherein boron in the activated carbon accounts for 1-3wt%, nitrogen in the activated carbon accounts for 4.1-9.2wt%, the specific surface area is 500-1000m<2> / g, and the pore size distribution is 0.46-2nm. The boron and nitrogen co-doping chitosan-base activated carbon takes the chitosan and the boric acid as raw materials and is prepared through co-pyrolysis. According to a method, the combining quantity of the boron in a carbon source and the dispersion degree of the boron in the carbon source are increased under the mutual action of the protonated chitosan and the boric acid, and the boron and nitrogen co-doping chitosan-base activated carbon is obtained through the co-pyrolysis. An environmental-friendly technology for preparing the activated carbon without consuming strong acid and strong alkali is realized, so that a costly and non-environmental-friendly process which consumes a great deal of activating agent and water during the traditional process for preparing the activated carbon is avoided. Moreover, the boron and nitrogen co-doping chitosan-base activated carbon has the advantages of short time consumption, simplicity in preparation technology, simplicity and easiness in equipment and the like.
Owner:DALIAN UNIV OF TECH
Niraparib granules with high utilization efficiency and preparation method thereof
ActiveCN110314094AStrong reductionPromote absorptionPharmaceutical product form changeSolid materialVitamin CD-Glucose
The invention discloses niraparib granules with a high utilization efficiency and a preparation method thereof, and belongs to the technical field of medicine production. The components of the niraparib granules include niraparib, glucose, vitamin C and a carboxylesterase inhibitor. A granule packaging machine adopted in the preparation method comprises a storage bin and a transparent upper discharge pipe, wherein the transparent upper discharge pipe penetrates through the storage bin, the two sides of the upper discharge pipe are provided with an infrared emitter and an infrared receiver respectively, the infrared emitter and the infrared receiver are capable of lifting and lowering, a turntable is arranged below the upper discharge pipe, a curved through hole is formed in the turntable,a retractable stop block with a proximity switch is arranged on one side of the turntable, and a curved groove is formed in the turntable. By adopting the niraparib granules, the amount of niraparib discharged along with excretion can be reduced, and the pharmacodynamic effect of the niraparib can be maintained; valve-related components of the granule packaging machine adopted in the preparation process of the niraparib granules have longer service life, it can be ensured that the amount of the material discharged each time is sufficient, the remaining granules with a remaining amount less than a set value are remained in the upper discharge pipe, and the application is convenient.
Owner:ANHUI HAIKANG PHARMA
Method for amplifying and sequencing nucleic acid based on solid phase carrier
ActiveCN102604934AIncrease profitIncrease the amount of bindingMicrobiological testing/measurementDNA preparationGene engineeringBiology
The invention relates to the field of gene engineering, and provides a method for amplifying and sequencing nucleic acid based on a solid phase carrier. At least one template sequence is fixed at the surface of the solid phase carrier, and the method comprises the following steps: A, combining a primer with a primer binding site on the surface of the solid phase carrier to obtain an amplifying carrier fixed with the primer; and B, amplifying the template sequence on the amplifying carrier to obtain a amplifying product. The method is based on the solid phase carrier fixed with the template sequence on the surface to amplify, can fix the amplifying product on the surface of the solid phase carrier, and improves the combining amount of the amplifying product on the surface of the solid phase carrier; and in addition, the solid phase carrier obtained by the amplifying method is utilized to sequence, so that a detection signal of the sequencing is strengthened, the requirements on a detection instrument are reduced, and the accuracy of the sequencing is improved in equal detection conditions.
Owner:盛司潼
Purification technology of recombination human interferon alpha 1b
InactiveCN1724568AReduce manufacturing costSolve pollutionPeptide preparation methodsInterferonsInterferon alphaSize-exclusion chromatography
The invention relates to a process for purifying recombinant human interferon alpha1b, which comprises hydrophobic column chromatography, cationic column chromatography and volume exclusion chromatography. The process requires no mono- anti-stripping affinity chromatography, thus can prevent the pollution caused by drops of mono-anti-stripping, and the technological process can be shortened.
Owner:BEIJING TRI PRIME GENE PHARMA CO LTD +1
Ecological bating method
This invention provides an ecological tanning method. The method comprises: pre-tanning with aldehyde tanning agent, tanning with tetrahydroxymethyl phosphonium salt, and then adding collagen to enhance the bonding of the tanning agents. The method utilizes the reaction among aldehyde tanning agent, tetrahydroxymethyl phosphonium salt and collagen to enhance the bonding of the tanning agents as well as increase the shinkage temperature. Besides, the addition of collagen can improve the comprehensive properties of leather and reduce the aldehyde content in leather. The method can be used to replace chrome tannage, thus can avoid the harm of chrome salt to human body and environment.
Owner:XUZHOU XINGNING LEATHER CO LTD
Method for realizing directional coupling by utilizing glycosyl of antibody and solid-phase carrier material
ActiveCN112630420ASolve random fixed problemsIncrease the amount of bindingDisease diagnosisBiological testingImmune profilingChemical compound
The invention relates to the field of biochemical synthesis, and provides a method for realizing directional coupling by utilizing glycosyl of an antibody and a solid-phase carrier material, a directional conjugate and an application. The method comprises the following steps that a solid-phase carrier material is modified by utilizing a modification reagent, so that the surface of the solid-phase carrier material is modified with a binding arm with a certain length and rich in amino groups, and the binding arm can extend into an Fc region of an antibody and react with the glycosyl of the antibody; the glycosyl of the antibody is oxidized into an aldehyde group; and the aldehyde group reacts with the amino group of the modified solid-phase carrier material to form Schiff base, and the Schiff base is reduced into an amine compound, thereby obtaining a directional conjugate. According to the invention, the problem that a solid-phase carrier material can be hardly coupled to glycosyl in an antibody is solved; the problem of random immobilization of an antibody and a solid phase carrier material is solved, and an active part, combined with an antigen, of an antibody can be fully exposed; and when the directional conjugate constructed by the invention is applied to immunoassay, more antigens can be recognized only by using a small amount of the directional conjugate, and the sensitivity of immunoassay determination is improved.
Owner:UNIV OF SCI & TECH BEIJING
Detection test strip capable of remarkably improving lateral flow immunochromatography
ActiveCN108535472AIncreased chances of contact bondingIncrease the amount of bindingMaterial analysisNitrocelluloseAnalyte
The invention provides a method for remarkably improving the strength of a detection signal of a lateral flow immunochromatography detection test strip. The method for improving the strength of the detection signal comprises the following steps: (a) after mixing a sample and an antibody marked on a fluorescent microsphere in vitro, adding a mixture onto a sample pad of chromatography test paper; (b) after combining a matter to be analyzed in the sample with the antibody marked on the fluorescent microsphere, forming a compound to be detected; gradually dispersing the compound to be detected toa nitrocellulose membrane along a chromatography flow; (c) dividing a detection line and a quality control line on the nitrocellulose membrane; (d) carrying out perforation modification on the nitrocellulose membrane between the sample pad and the detection line to obtain a modification region formed by 1 to 10 rows of modification holes. According to the method provided by the invention, the aims of increasing the probability of capturing the compound to be detected, reducing the time of uniformly blending in vitro, improving the testing sensitivity, reducing the measurement limit value and / or improving the detection signal can be realized.
Owner:上海艾瑞德生物科技有限公司
Water-soluble oxidized chitosan and method for finishing fabric by using water-soluble oxidized chitosan
ActiveCN114000350AShort and uniform reaction timeIncrease oxidation rateWrinkle resistant fibresBiochemical treatment with enzymes/microorganismsHydrogen SulfateO-Phosphoric Acid
The invention discloses water-soluble oxidized chitosan and a finishing method of the water-soluble oxidized chitosan on a fabric. The water-soluble oxidized chitosan is prepared by the following steps: dissolving chitosan in a 1-carboxymethyl-3-methylimidazolium hydrogen sulfate aqueous solution, oxidizing C2 and C3 sites of the chitosan by sodium periodate under microwave radiation to generate aldehyde groups, and then oxidizing primary hydroxyl at C6 site of the dialdehyde chitosan in an ionic liquid by concentrated nitric acid-concentrated phosphoric acid to generate carboxyl. The water-soluble oxidized chitosan can be used for modifying fabrics. Compared with a traditional chemical cross-linking agent modified fabric, the method has the advantages that the grafting efficiency of the oxidized chitosan is high, the enzyme treatment condition is mild, the reaction process is simple, the fabric is crease-resistant, antibacterial, efficient and lasting, the fabric is comfortable to wear, and the requirements of people on lasting functional ecological textiles are met.
Owner:ANHUI AGRICULTURAL UNIVERSITY
EVA (Ethylene Vinyl Acetate) master batch as well as preparation method and application thereof
InactiveCN106674710ALuminous intensity is not affectedReduce exposureCompound organicSURFACTANT BLEND
The invention in particular discloses an EVA (Ethylene Vinyl Acetate) master batch. The EVA master batch is prepared from the following raw materials in percentage by mass: 40 percent to 50 percent of EVA, 30 percent to 40 percent of luminous powder, 1.0 percent to 1.5 percent of kaolin, 2.0 percent to 3.0 percent of a dispersant, 2.5 percent to 4.0 percent of an anti-ageing agent and 10 percent to 12 percent of a compound organic coating agent, wherein the luminous powder is alkaline earth aluminate system long afterglow luminous powder, and the grain size is 12mu m to 20mu m. According to the EVA master batch, a maleic anhydride organic ligand is introduced to the surface of the luminous powder, and the luminous powder more uniformly and densely coats the surface of the luminous powder by utilizing a gemini surfactant, so that contact between the luminous powder and external moisture or metal is reduced, and a product does not turn black; meanwhile, the combination firmness of the luminous powder and the organic ligand is improved, the hydrolyzing resistance of the product and the compatibility between the product and the EVA are greatly improved, and the influences on luminous performance of the luminous powder are very small.
Owner:JINJIANG XINBANG NEW MATERIAL TECH
Preparation method of enzyme immobilization carrier and application of enzyme immobilization carrier to immunoassay
InactiveCN104195127AHigh activityIncrease the amount of bindingBiological testingOn/in organic carrierEnzyme linked immunoassayElectrostatic adsorption
The invention discloses a preparation method of an enzyme immobilization carrier and application of the enzyme immobilization carrier. According to the preparation method of the enzyme immobilization carrier, a polyelectrolyte ball brush is taken as a carrier, an enzyme is immobilized by using a method of carrying out electrostatic adsorption and then carrying out chemical coupling, and the prepared compound is applied to immunoassay. By virtue of the preparation method of the enzyme immobilization carrier, high binding capacity and high activity of the enzyme are achieved; the sensitivity of the enzyme-linked immunoassay can be remarkably improved when the enzyme immobilization carrier is applied to the enzyme-linked immunoassay.
Owner:SHANGHAI JIAO TONG UNIV
Artificial antigen presenting cells and preparation method and application thereof
ActiveCN110464848ALarge specific surface areaIncrease the amount of bindingPowder deliveryInorganic non-active ingredientsRough surfaceSignalling molecules
The invention discloses artificial antigen presenting cells and a preparation method and application thereof. According to the preparation method of the artificial antigen presenting cells, a polymermicrosphere surface topological structure morphological control method is established, an antigen presenting function of microspheres is achieved through signal molecule modification, and thus the microspheres can be used for stimulating immune cell amplification and activation. According to the artificial antigen presenting cells, adopted materials have biocompatibility and biodegradability, andthe preparation method of the microspheres with a rough surface structure is easy to operate, environmentally friendly and good in reproducibility.
Owner:CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI +1
Method for processing and producing down jacket with aromatic odor
ActiveCN113062119AImprove bindingIncrease the amount of bindingFibre treatmentAgainst vector-borne diseasesMesoporous materialOrganic chemistry
The invention discloses a method for processing and producing down jackets with aromatic odor. The method comprises the following steps of 1, selecting down feathers, and pre-treating the down feathers, so that micron-sized holes are distributed in the surfaces of the down feathers; 2, selecting essential oil with aromatic smell, and performing high magnetization treatment on the essential oil to make essential oil particles micronized; 3, soaking the down feather treated in the step 1 in the essential oil treated in the step 2, pressurizing a soaking system in the soaking process, separating the down feather after soaking, and naturally airing the down feather; 4, uniformly spraying a mesoporous material on the surface of the down feather treated in the step 3 to form a slow-release coating; and 5, selecting the down feather treated in the step 4, and producing and processing the down feather to obtain the down jacket with aromatic odor. The down jacket prepared by the method can effectively prolong the fragrance emission time, the emission rate is uniform, and the phenomenon that the fragrance is too strong in the early stage is effectively avoided.
Owner:ANHUI GUIGU E COMMERCE
Preparation method and application of Ni-NTA modified silicon dioxide coated ferroferric oxide magnetic nano functional assembly
ActiveCN111167409ASimple processHigh carboxyl densityIon-exchange process apparatusOther chemical processesChemistryFerriferrous Oxide
The invention discloses a preparation method and applications of a Ni-NTA modified silicon dioxide coated ferroferric oxide magnetic nano functional assembly, and belongs to the field of materials. The preparation method comprises the following steps: preparing Fe3O4 nanoclusters by a solvothermal method; preparing Fe3O4@SiO2 magnetic nanoparticles by a St-ber sol-gel method; adding a silane coupling agent, and carrying out surface carboxylation of Fe3O4@SiO2 (Fe3O4@SiO2@COOH) through a chemical method; introducing an activating agent, and completing NTA modification (Fe3O4@SiO2@COOH@NTA) on the surfaces of the carboxylated Fe3O4@SiO2 magnetic nanoparticles; and adding Ni<2+> to prepare the assembly. According to the invention, the steps are clear, and the prepared magnetic nano functionalassembly is rich in surface groups, large in Ni<2+> binding capacity, high in binding force with His tag protein and high in separation efficiency.
Owner:甘肃省科学院传感技术研究所
Reagent and kit for rapidly extracting nucleic acid from FFPE sample and application of reagent and kit
The invention belongs to the technical field of molecular biology, and particularly discloses a reagent and a kit for rapidly extracting nucleic acid from an FFPE sample and application of the reagent and the kit. The combination buffer solution in the reagent is simple in formula and low in cost, the combination effect of the nucleic acid and the magnetic beads can be remarkably improved, and the combination amount of the nucleic acid is increased. According to the method, the lysis buffer solution, the binding buffer solution and the washing buffer solution with specific components are combined for use, tissue cells are fully lysed, protein bound with nucleic acid is digested, the nucleic acid is completely released, then the released nucleic acid is specifically bound to the magnetic beads, the binding amount of the nucleic acid is increased, effective separation of the nucleic acid and other lysates is achieved, the magnetic beads combined with the nucleic acid are washed for multiple times, impurities such as protein and lipid are thoroughly removed, and the nucleic acid isfinally eluted from the magnetic beads to obtain high-purity and high-yield nucleic acid. The reagent / kit is simple in composition, low in cost and convenient for nucleic acid extraction operation, and the extraction time can be greatly shortened.
Owner:AUTOBIO DIAGNOSTICS CO LTD
Organic hydrotalcite and preparation method thereof
InactiveCN102861552AIncrease the amount of bindingImprove adsorption capacityOther chemical processesHydrotalciteSURFACTANT BLEND
The invention relates to development of a new material for controlling environmental pollution, and discloses organic modified hydrotalcite and a preparation method thereof. Although some existing methods are used for modifying the hydrotalcite to obtain the organic hydrotalcite, organic hydrotalcite of the prior art is comparatively low in capacity of adsorbing organic pollutants. According to the preparation method, an anionic surfactant and a nonionic surfactant are adopted to modify the hydrotalcite; the combining capacity of the nonionic surfactant is increased by the anionic surfactant; and meanwhile, the total quantity of organic carbons on the surface of the hydrotalcite is increased by the anionic surfactant, therefore the adsorption capacity of the organic pollutants on the surfaces of particles is greatly increased.
Owner:CHANGZHOU UNIV
Electrode modified with single-walled carbon nanohorn-platinum and palladium nano particles and cytomegalovirus pp65 antibody and preparation method and application thereof
InactiveCN104132984ALarge specific surface areaIncrease the amount of bindingMaterial electrochemical variablesCytomegalovirus antigenSingle-walled carbon nanohorn
The invention discloses an electrode modified with single-walled carbon nanohorn-platinum and palladium nano particles and cytomegalovirus pp65 antibody, and a preparation method and an application thereof. The electrode is prepared by the steps of treating single-walled carbon nanohorn dispersed by a perfluorinated sulfonic acid-polytetrafluoroethylene copolymer membrane, then absorbing thionine, and then combining with the single-walled carbon nanohorn-platinum and palladium nano particles, incubating the cytomegalovirus pp65 antibody and finally sealing with horse radish peroxidase (HRP). The prepared electrode is combined with single-walled carbon nanohorn modified with chitosan; since the single-walled carbon nanohorn has large specific surface area and good biocompatiability, after being modified with amino, the single-walled carbon nanohorn is further beneficial to stabilization of platinum and palladium particles, improvement of the combined quantity of the cytomegalovirus pp65 antibody and increase of the peak current value; in addition, the platinum and palladium particles and HRP can catalyze hydrogen peroxide and amplify a detection signal, thus improving the sensitivity of detection on cytomegalovirus antigen with low concentration.
Owner:THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
Method for preparing organic mineralized refuses through modification of cationic and non-ionic surfactants
InactiveCN102806072AIncrease the amount of bindingIncrease expansionOther chemical processesWater/sewage treatment by sorptionWater bathsGram
The invention provides a method for preparing organic mineralized refuses through modification of cationic and non-ionic surfactants. The method comprises the following steps: 1) drying the mineralized refuses by air; crushing the dried mineralized refuses to remove impurities; filtering the mineralized refuses by a screen of 40-200 meshes; adding the mineralized refuses to an cationic surfactant solution; and stirring the mineralized refuses and the cationic surfactant solution in a water bath for 2-8 h at 50-80 DEG C; 2) adding the non-ionic surfactant to a mixture, wherein 0.1-0.3 g non-ionic surfactant is added to each gram of mineralized refuses; stirring the mixture in the water bath for 2-4 h at 50-80 DEG C; filtering an obtained product; washing the product by a distilled water; drying the product at 60-90 DEG C after filtering the product; activating the dried product for 30 minutes to 5 hours at 105-110 DEG C; grinding the product; and filtering the product by a screen of 50-100 meshes so as to prepare organic mineralized refuses modified by the cationic and non-ionic surfactants. The method for preparing the organic mineralized refuses through modification of the cationic and non-ionic surfactants, provided by the invention, has the advantage that the mineralized refuses are respectively modified by the cationic and non-ionic surfactants according to a certain mixing ratio so as to improve the adsorption quantity of the mineralized refuses to phenols.
Owner:CHANGZHOU UNIV
Wool product biological process mould-proof finishing technology based on cutinase pretreatment
InactiveCN102965957AImprove hydrophilicityImprove responseBiochemical fibre treatmentAnimal fibresCutinasePre treatment
The invention discloses a wool product biological process mould-proof finishing technology based on cutinase pretreatment, belonging to the technical field of wool fabric dyeing and finishing, which is aimed at realizing a mould-proof effect of a wool product by use of lysozyme. The technology disclosed by the invention can solve the problems of the traditional mould-proof method that a chemical mould inhibitor has toxicity and a colored mould inhibitor influences appearance and mould-proof effect of wool fabric and is not resistant to washing and the like. The technology comprises the following steps of: processing wool in a cutinase solution with certain concentration at certain temperature and pH value to remove a hydrophobic lipoid layer on the wool surface and improve the hydrophilicity of wool and expose a reactive group on the wool surface; impregnating the pretreated wool in a solution with certain pH value, and adsorbing lysozyme on wool fiber through electrostatic interaction; and processing the wool fiber with pre-adsorbed lysozyme in a glutaraldehyde solution with certain concentration at certain temperature for certain time, and fixing the lysozyme on the wool product through electrostatic adsorption and chemical crosslinking effect; and performing washing and low-temperature drying.
Owner:JIANGNAN UNIV
Sensitization test strip for rapidly detecting cronobacter sakazakii and application of sensitization test strip
The invention discloses a sensitization test strip for rapidly detecting cronobacter sakazakii and application of the sensitization test strip, and belongs to the technical field of detection of cronobacter sakazakii. The sensitization test strip comprises a sample pad, a gold standard pad, an NC film, an absorbent pad and a bottom plate, wherein the NC film is provided with a detection line and acontrol line, the control line is coated with a goat anti-mouse secondary antibody, and a detection line solution coating the detection line is obtained by incubating colloidal gold and an anti-cronobacter sakazakii capture antibody. The sensitization test strip has the characteristic of being capable of improving the protein binding quantity on the NC film, thereby enhancing the capture rate; the colloidal gold added at the detection line can improve aggregation coloration, thereby improving the detection effect; and the sensitivity is improved by 100 times compared with a traditional test strip, and the sensitization test strip has high specificity, short detection time, easy manufacture and a low cost, and is easy to carry and suitable for on-site detection of cronobacter sakazakii.
Owner:NORTHEAST AGRICULTURAL UNIVERSITY
Anhydrous reactive dye printing paste and printing process
The invention provides a printing process, which comprises preparation of anhydrous reactive dye printing paste, printing, drying and aftertreatment. The preparation of the anhydrous reactive dye printing paste comprises the following steps: S1, taking a predetermined amount of dimethylformamide (DMF) and adding a predetermined amount of polyurethane into the dimethylformamide; and S2, taking a predetermined amount of polyurethane solution prepared in the step S1, adding a predetermined amount of reactive dye and a predetermined amount of halogenated hydrocarbon into the polyurethane solutionand continuously stirring for 10 to 30 minutes to obtain the anhydrous reactive dye printing paste. The anhydrous reactive dye printing paste consists of the following components in percentage by weight: 35 to 47.5 percent of dimethylformamide, 2.5 to 15 percent of polyurethane, 0.5 to 1.5 percent of reactive dye and 37.5 to 62.5 percent of halogenated hydrocarbon. Thus, in a paste system of halogenated hydrocarbon / DMF / polyurethane, reactive dye molecules are rapidly pushed and attracted to fiber and then are adsorbed by the fiber at once, and the obtained printing textile product has clear boundary and has high color fastness; and the anhydrous reactive dye printing paste has simple components and is simple in preparation process.
Owner:WUHAN TEXTILE UNIV
Preparation method of modified porous plate
ActiveCN102072955BReduce the initial redox reaction rateQuick buildBiological testingNanoparticleAqueous solution
The present invention belongs to the field of modification of a medical apparatus and the field of a nano material, and particularly relates to a preparation method of a modified porous plate, which comprises the following steps: (1), preparing aqueous solution containing potassium bicarbonate, glucose and chloroauric acid at 0-25 DEG C, adjusting the pH of the solution to be 9.0-10.0 with alkaline solution, and cooling the solution; and (2) filling the solution obtained in Step (1) into holes of the porous plate with 50-250muL for each hole, heating the porous plate for 1-6 hour(s) at 25-50 DEG C, eliminating the solution in the holes, and washing the porous plate for twice to three times with deionized water, therefore, the stable porous plate collectively modified by gold nanoparticlesis obtained. The gold nanoparticles are produced through chemical reduction, and are attached to the surface of the porous plate through physical settlement to form a stable and uniform gold nanoparticle aggregation layer. Due to the large specific surface area and the unique three-dimensional structure of the gold nanoparticle aggregation layer, the protein binding capacity of the modified surface can be improved. Therefore, the modified porous plate can realize ultra-high-sensitivity enzyme-linked immunosorbent assay tests.
Owner:BIOMODI BIOTECH SUZHOU CO LTD
A bifunctional monomer double imprinted layer testosterone molecularly imprinted magnetic nanosphere and its preparation method and application
ActiveCN112661964BIncrease forceEnhanced interactionOther chemical processesSolid sorbent liquid separationFunctional monomerProstate cancer
The invention discloses a bifunctional monomer double imprinted layer testosterone molecularly imprinted magnetic nanosphere and a preparation method and application thereof, which belong to the technical field of nanomaterial preparation and nanomedicine. Using magnetic nanospheres modified with amphiphilic functional groups as the carrier, testosterone as the template molecule, and 3-aminopropyltriethoxysilane and phenyltrimethoxysilane as the bifunctional monomers, the template and surface were immobilized in two steps. The bifunctional monomer double imprinted layer testosterone molecularly imprinted magnetic nanospheres were prepared by combining imprinting. The bifunctional monomer double imprinted layer testosterone molecularly imprinted magnetic nanosphere prepared by the method of the present invention has uniform particle size, good structural stability, high selectivity, rich functional monomer groups, and good biological safety; the method is a A new method for preparing molecularly imprinted polymers with high adsorption capacity and high selectivity for testosterone can significantly improve the efficiency of castration therapy for prostate cancer by fully adsorbing and removing intracellular testosterone, and provide new ideas for endocrine therapy for prostate cancer.
Owner:XI AN JIAOTONG UNIV
A test strip that significantly improves lateral flow immunochromatography
ActiveCN108535472BIncreased chances of contact bondingIncrease the amount of bindingMaterial analysisAnalyteTest strips
The invention provides a method for significantly improving the detection signal intensity of a lateral flow immunochromatography test strip, and the method for improving the detection signal intensity includes the steps: (a) adding the sample and the antibody labeled on the fluorescent microspheres to the (b) the analyte in the sample combines with the antibody labeled on the fluorescent microsphere to form a complex to be tested, and the complex to be tested gradually diffuses to the nitrocellulose membrane along with the chromatographic flow; (c) Divide the detection line and the quality control line on the nitrocellulose membrane; (d) carry out modification by punching holes on the nitrocellulose membrane between the sample pad and the detection line, and obtain the modification formed by 1-10 rows of modified holes Area. The present invention can achieve the purpose of increasing the probability of the compound to be detected being captured, reducing the mixing time in vitro, improving the test sensitivity, reducing the measurement limit value, and / or improving the detection signal.
Owner:上海艾瑞德生物科技有限公司
A tetracycline hollow double imprinted layer magnetic nanosphere and its preparation method and application
ActiveCN110801817BEasy surface functionalizationEasy to separateOther chemical processesWater contaminantsMagnetite NanoparticlesMagnetic nanospheres
The invention discloses tetracycline hollow double-imprinted layer magnetic nanospheres as well as a preparation method and application thereof and belongs to the technical field of preparation of nanomaterials and application in environmental chemistry. The preparation method comprises the following steps: firstly, synthesizing magnetic nanoparticles with a small particle size by using a co-precipitation method at one step; synthesizing silicon spheres by using a method; further adding the silicon spheres, magnetic spheres, dopamine and tetracycline to a Tris-HCl buffer, performing sufficientstirring at room temperature, performing washing, separation and vacuum drying on the product, and repeating a wrapping step; and finally etching off the silicon spheres by using sodium carbonate soas to form a polymer of a hollow structure, separating out the generated polymer by using external magnetic spheres, and performing elution and vacuum drying, so as to obtain the tetracycline hollow double-imprinted layer magnetic nanospheres. The tetracycline hollow double-imprinted layer magnetic nanospheres disclosed by the invention are uniform in particle size, good in structure stability, strong in magnetic responsiveness, good in reusability, large in selective adsorption capacity for tetracycline, large in adsorption capacity, fast in mass transfer rate, high in recovery rate, meanwhile, low in material cost and simple to prepare.
Owner:XI AN JIAOTONG UNIV
A kind of preparation method of leather fatliquor
InactiveCN105296688BIncrease the amount of bindingGuaranteed chlorine contentLeather impregnationSulfonateVegetable oil
The invention relates to a preparation method of a novel leather fatliquor. The purpose is to provide a simple and feasible process, low emission of three wastes, green environmental protection, stable product quality, and excellent fatliquoring performance. The technical scheme is: a preparation method of a novel leather fatliquoring agent, which is carried out according to the following steps: heating the continuously input animal and vegetable oil to a certain temperature, then inputting gas-phase SO3 to carry out SO3 membrane sulfonation reaction, and controlling the SO3 binding amount; Chlorine gas is introduced into the sulfonated animal and vegetable oil, and the chlorinated animal and vegetable oil sulfonate is prepared by chlorination reaction, and the chlorine content is controlled; 3. The chlorinated animal and vegetable oil sulfonate is neutralized and decolorized with alkali to obtain the leather added. Fat products.
Owner:ZANYU TECH GRP CO LTD +1
Bread rich in litchi bonded phenol and preparation method thereof
ActiveCN112913883AImprove water holding capacityConjugated phenol content increasedDough treatmentFood processingBiotechnologyFiber
The invention discloses bread rich in litchi bonded phenol and a preparation method thereof The bread comprises the following raw materials in parts by mass: 2 to 25 parts of litchi bonded phenol fruit powder, 1 to 5 parts of dry yeast, 1 to 5 parts of cane sugar, 1 to 5 parts of salt, 40 to 60 parts of egg liquid, 55 to 85 parts of high gluten flour and 200 to 300 parts of water, wherein a preparation method of the litchi bonded phenol fruit powder comprises the following steps of: S1, after peeling, denucleating and cleaning litchis, carrying out juicing, and centrifuging to remove supernatant so as to obtain litchi pomace; S2, carrying out intermittent process and heat pump infrared combined drying on the litchi pomace; and S3, carrying out superfine grinding on the dried litchi pomace to obtain the litchi bonded phenol fruit powder with the particle size less than 500 mum. According to the bread prepared by adopting the litchi fruit powder rich in litchi bonded phenol, which is disclosed by the invention, under the condition of keeping the content of dietary fibers, the content of the bonded phenol in the bread is increased, and the effects of supplementing dietary polyphenol and improving the taste, flavor and water holding capacity of the bread are taken.
Owner:GUANGZHOU UNIVERSITY
Tetracycline hollow double-imprinted layer magnetic nanospheres as well as preparation method and application thereof
ActiveCN110801817AEasy surface functionalizationEasy to separateOther chemical processesWater contaminantsMagnetite NanoparticlesMagnetic nanospheres
Owner:XI AN JIAOTONG UNIV
A kind of hydrophilic sulindac molecularly imprinted magnetic nano resin ball and its preparation method and application
ActiveCN109293859BGood dispersionStrong chemical resistanceOther chemical processesAlkali metal oxides/hydroxidesMagnetic responseMagnetic nanospheres
The invention discloses hydrophilic sulindac molecularly imprinted magnetic nanoresin spheres, and a preparation method and an application thereof, and belongs to the technical fields of nanomaterialpreparation and environmental chemistry application. The preparation method comprises the steps: firstly, synthesizing carboxyl magnetic nanospheres by a hydrothermal method in one step; then, addingthe carboxyl magnetic nanospheres and sulindac to ultra-pure water, and followed by adding ammonia water to obtain a template-carrier complex; then adding resorcinol and formaldehyde, and polymerizingto obtain a solid polymer; and finally, separating the solid polymer by an externally applied magnetic field, and eluting and drying the polymer, to obtain the hydrophilic sulindac molecularly imprinted magnetic nanoresin spheres. The prepared hydrophilic sulindac molecularly imprinted magnetic nanoresin spheres have the advantages of uniform particle size, good structural stability, strong magnetic response, strong reusability, good hydrophilicity, strong selective adsorption capacity on sulindac, large adsorption capacity, high recovery rate, low cost of materials and simple preparation.
Owner:XI AN JIAOTONG UNIV
Difunctional monomer double-imprinting-layer testosterone molecular imprinting magnetic nanosphere as well as preparation method and application thereof
ActiveCN112661964AIncrease forceEnhanced interactionOther chemical processesSolid sorbent liquid separationFunctional monomerPhenyl group
The invention discloses a difunctional monomer testosterone molecularly imprinted magnetic nanosphere with double imprinted layers as well as a preparation method and application of the magnetic nanosphere, and belongs to the technical field of nano-material preparation and nano-medicine. Magnetic nanospheres modified by amphiphilic functional groups are used as carriers, testosterone is used as template molecules, 3aminopropyltriethoxysilane and phenyltrimethoxysilane are used as bifunctional monomers, and the bifunctional monomer double-imprinting-layer testosterone molecularly imprinted magnetic nanospheres are prepared by adopting a method of combining a two-step fixed template and surface imprinting. The difunctional monomer double-imprinting-layer testosterone molecularly imprinted magnetic nanospheres prepared by the method disclosed by the invention are uniform in particle size, good in structural stability, high in selectivity, rich in functional monomer groups and good in biological safety; and the method is a new method for preparing the testosterone molecularly imprinted polymer with high adsorption capacity and high selectivity, the testosterone in cells is removed through full adsorption, the efficiency of castration treatment of the prostate cancer can be remarkably improved, and a new thought is provided for endocrine treatment of the prostate cancer.
Owner:XI AN JIAOTONG UNIV
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