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A tetracycline hollow double imprinted layer magnetic nanosphere and its preparation method and application

A magnetic nanosphere, tetracycline technology, applied in chemical instruments and methods, other chemical processes, water/sludge/sewage treatment, etc., can solve the problems of increasing bacterial resistance, time-consuming separation process, complex efficiency, etc., to achieve easy surface Functionalization, uniform particle size, and the effect of increasing mass transfer rate

Active Publication Date: 2020-10-27
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tetracyclines may increase bacterial resistance
Due to the convenient operation of magnetic separation, combining this technology with molecular imprinting technology solves the problems of time-consuming, complicated and low-efficiency separation compared with the previous non-magnetic MIPs

Method used

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  • A tetracycline hollow double imprinted layer magnetic nanosphere and its preparation method and application
  • A tetracycline hollow double imprinted layer magnetic nanosphere and its preparation method and application
  • A tetracycline hollow double imprinted layer magnetic nanosphere and its preparation method and application

Examples

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Effect test

Embodiment 1

[0037] A method for preparing tetracycline hollow double imprinted layer magnetic nanospheres, comprising the following steps:

[0038] Step 1. Put 1.0g of ferric chloride hexahydrate, 20mL of secondary water, 5mL of ammonia water, and 1.05g of ferric chloride tetrahydrate into a three-necked flask, and react at 25°C for 10min. Wash with water, and dry in vacuum at 20°C and 0.02MPa for 3h. Such as figure 1 As shown, the particle size of the prepared small-diameter magnetic nanosphere is about 5nm.

[0039] Step 2: Put 5mL of concentrated ammonia water, 10mL of ethanol and 10mL of distilled water in a three-necked flask, and mechanically stir for 5min at a speed of 1000r / min. Stir mechanically for 1 h under the condition, and finally centrifuge to obtain silica nanospheres. Such as figure 2 As shown, the particle size of the prepared silica nanospheres is about 250nm.

[0040] Step 3: Place 10 mg of small-diameter magnetic nanospheres, 10 mg of tetracycline, 20 mg of sili...

Embodiment 2

[0052] A method for preparing tetracycline hollow double imprinted layer magnetic nanospheres, comprising the following steps:

[0053] Step 1. Put 2.0g of ferric chloride hexahydrate, 30mL of secondary water, 8mL of ammonia water, and 2.72g of ferric chloride tetrahydrate in a three-necked flask, and react at 40°C for 50min. Washing with water, drying in vacuum at 30° C. and 0.04 MPa for 4 hours to prepare magnetic nanospheres with small particle size.

[0054] Step 2. Put 10mL of concentrated ammonia water, 21mL of ethanol and 22mL of distilled water in a three-necked flask, and mechanically stir for 10min at a speed of 1200r / min. Add 3mL of TEOS and 25mL of ethanol to the above solution at a speed of 150r / min. The mixture was mechanically stirred for 3 hours, and finally centrifuged to obtain silica nanospheres.

[0055] Step 3: Put 15mg of magnetic nanospheres, 15mg of tetracycline, 40mg of silicon spheres, 60mg of dopamine and 10mL of Tris-HCl in a reaction vessel, and m...

Embodiment 3

[0067] A method for preparing tetracycline hollow double imprinted layer magnetic nanospheres, comprising the following steps:

[0068] Step 1. Put 4.5g of ferric chloride hexahydrate, 40mL of secondary water, 12mL of ammonia water, and 3.5g of ferric chloride tetrahydrate into a three-necked flask, and react at 55°C for 100min. Wash with water, and dry in vacuum at 40°C and 0.05MPa for 5h. Small-diameter magnetic nanospheres are prepared.

[0069] Step 2. Put 15mL of concentrated ammonia water, 30mL of ethanol and 35mL of distilled water in a three-necked flask, and mechanically stir for 15min at a speed of 1500r / min. Add 5mL of TEOS and 35mL of ethanol to the above solution at a speed of 200r / min. The mixture was mechanically stirred for 5 h, and finally centrifuged to obtain silica nanospheres.

[0070] Step 3: Put 20mg of magnetic nanospheres, 18mg of tetracycline, 70mg of silicon spheres, 78mg of dopamine and 15mL of Tris-HCl in a reaction vessel, and mechanically stir ...

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Abstract

The invention discloses tetracycline hollow double-imprinted layer magnetic nanospheres as well as a preparation method and application thereof and belongs to the technical field of preparation of nanomaterials and application in environmental chemistry. The preparation method comprises the following steps: firstly, synthesizing magnetic nanoparticles with a small particle size by using a co-precipitation method at one step; synthesizing silicon spheres by using a method; further adding the silicon spheres, magnetic spheres, dopamine and tetracycline to a Tris-HCl buffer, performing sufficientstirring at room temperature, performing washing, separation and vacuum drying on the product, and repeating a wrapping step; and finally etching off the silicon spheres by using sodium carbonate soas to form a polymer of a hollow structure, separating out the generated polymer by using external magnetic spheres, and performing elution and vacuum drying, so as to obtain the tetracycline hollow double-imprinted layer magnetic nanospheres. The tetracycline hollow double-imprinted layer magnetic nanospheres disclosed by the invention are uniform in particle size, good in structure stability, strong in magnetic responsiveness, good in reusability, large in selective adsorption capacity for tetracycline, large in adsorption capacity, fast in mass transfer rate, high in recovery rate, meanwhile, low in material cost and simple to prepare.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation and environmental chemical application, and in particular relates to a tetracycline hollow double imprinted layer magnetic nanosphere and its preparation method and application. Background technique [0002] Tetracycline antibiotics are antibacterial substances isolated from the culture fluid of the actinomycete Streptomyces aureofa-ciens, which are effective against Gram-positive bacteria, negative bacteria, Rickettsia, viral viruses, Spirochetes and even Protozoa have a good inhibitory effect, is a broad-spectrum antibiotics. Preparations obtained by chemically modifying natural tetracyclines (picoline, etc.) and semisynthetic tetracycline derivatives (methadone, etc.) have been used in medical practice. Currently, there are about forty natural tetracyclines and more than three thousand synthetic tetracyclines known. Tetracycline is a yellow crystalline substance, easily solub...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30C02F1/28C02F101/34
CPCB01J20/06B01J20/103B01J20/262B01J20/28009B01J20/28021B01J2220/46B01J2220/4806B01J2220/4812C02F1/281C02F1/285C02F2101/34
Inventor 高瑞霞王悦徐媛田雪蒙赵文昌
Owner XI AN JIAOTONG UNIV
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