Method for detecting 1-phenyl-2-(N-pyrrolidinyl)-1-butanone

A pyrrolidinyl and phenyl technology, which is applied in the detection field of 1-phenyl-2--1-butanone, and can solve the problems of lack of new psychoactive substances and the like

Inactive Publication Date: 2019-10-11
INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on new psychoactive substances in our country is still very scarce, and the qualitative and quantitative detection method for regulated 1-phenyl-2-(N-pyrrolidinyl)-1-butanone is still blank, so it is urgent to establish its qualitative Quantitative detection methods to provide technical support for the investigation and prosecution of related cases

Method used

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  • Method for detecting 1-phenyl-2-(N-pyrrolidinyl)-1-butanone
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  • Method for detecting 1-phenyl-2-(N-pyrrolidinyl)-1-butanone

Examples

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Embodiment 1

[0093] Example 1. Detection of 1-phenyl-2-(N-pyrrolidinyl)-1-butanone in suspected drug samples by gas chromatography-mass spectrometry and gas chromatography

[0094] 1 Reagents and standard substances, instruments and measuring instruments

[0095] 1.1 Reagents and standard substances

[0096] All reagents used in this method are of analytical grade.

[0097] Extraction reagent: Methanol.

[0098] Traceable reference material: α-PBP.

[0099] 1.2 Instruments and measuring instruments

[0100] Gas Chromatograph (GC) equipped with Flame Ionization Detector (FID).

[0101] Gas chromatography-mass spectrometry (GC-MS), a quadrupole mass spectrometer equipped with a standard electron impact (EI) source.

[0102] centrifuge.

[0103] Electronic balance, actual division value d=0.01mg.

[0104] oscillator.

[0105] 10mL and 1mL pipettes or pipettes.

[0106] 10mL bottle top pipette.

[0107] Note: All instruments and measuring instruments involved in this standard must pa...

Embodiment 2

[0211] Example 2. Detection of 1-phenyl-2-(N-pyrrolidinyl)-1-butanone in suspected drug samples by liquid chromatography-tandem mass spectrometry and liquid chromatography

[0212] 1 Reagents and standard substances, instruments and measuring instruments

[0213] 1.1 Reagents and standard substances

[0214] The reagents used are chromatographically pure, and the test water is first-grade water (see GB / T 6682-2008). The reagents and standard substances include:

[0215] a) Reagents: methanol, acetonitrile, formic acid, phosphoric acid, triethylamine;

[0216] b) Traceable reference material: α-PBP;

[0217]c) 0.1% formic acid aqueous solution: measure 1mL of formic acid, add water to dissolve and dilute to 1000mL, mix well, filter through a 0.22μm filter membrane, and let it stand for use after ultrasonication;

[0218] d) Phosphoric acid-triethylamine buffer solution: Measure 4.12mL of concentrated phosphoric acid, add 200mL of water to dilute; measure 5.56mL of triethylam...

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Abstract

The invention discloses a method for detecting 1-phenyl-2-(N-pyrrolidinyl)-1-butanone. The method includes the following steps: (1) dissolving a suspected drug sample in an organic solvent to extract1-phenyl-2-(N-pyrrolidinyl)-1-butanone and collecting an extract; and (2) performing qualitative detection on the extract by jointly using gas chromatography-mass spectrometry, comparing an obtained gas chromatogram-mass spectrogram of the extract with a gas chromatogram-mass spectrogram of a standard 1-phenyl-2-(N-pyrrolidinyl)-1-butanone substance, and when two conditions a)-b) as follows are satisfied at the same time, determining that 1-phenyl-2-(N-pyrrolidinyl)-1-butanone is detected, and otherwise, and determining that 1-phenyl-2-(N-pyrrolidinyl)-1-butanone is not detected: a) the relative error between the retention time of a target substance in the extract and the retention time of the standard substance is smaller than 2%; and b) the matching degree of a mass spectrogram of the target substance in the extract with the background deducted and a mass spectrogram of the standard substance with the background deducted is greater than 90%. The invention establishes a qualitative and quantitative analysis method of 1-phenyl-2-(N-pyrrolidinyl)-1-butanone and the method is quick, simple, easy to operate and easy to popularize and apply.

Description

technical field [0001] The invention relates to a detection method of 1-phenyl-2-(N-pyrrolidinyl)-1-butanone, which belongs to the field of criminal investigation drug detection. Background technique [0002] New psychoactive substances, English name New psychoactive substances, referred to as NPS, early called Legal Highs or Designer Drug, Chinese called "legal stimulants" or "planning drugs", is the research and production of some controlled drugs in order to avoid crackdowns. The drug analogs obtained by structural modification have similar effects to controlled drugs, and some have stronger excitatory, hallucinogenic, and anesthetic effects. The United Nations Office on Drugs and Crime (UNODC) divides new psychoactive substances into 9 categories, namely: synthetic cannabinoids, cathinones, phenethylamines, tryptamines, piperazines, ketamines and benzene rings. Ridines, aminoindenes, plants and others. Among them, synthetic cannabinoids and cathinones are the most abus...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/34
CPCG01N30/02G01N30/06G01N30/34G01N2030/047G01N2030/062G01N2030/342
Inventor 钱振华
Owner INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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