Photocrosslinking double-modified silk fibroin-gelatin composite bio-ink as well as preparation method and application thereof

A silk fibroin, bio-ink technology, applied in the directions of additive manufacturing, manufacturing tools, metal processing equipment, etc., can solve the problems of brittle large gel structure and other problems, achieve a high degree of automation, good compression resistance and elasticity, enhanced The effect of mechanical properties
CN110330797AInactive Publication Date: 2019-10-15DONGHUA UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DONGHUA UNIV
Publication Date
2019-10-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a photocrosslinking double-modified silk fibroin-gelatin composite bio-ink as well as a preparation method and application thereof. The photocrosslinking double-modified silkfibroin-gelatin composite bio-ink is prepared by respectively modifying silk fibroin and gelatin by methacrylation and performing photocrosslinking. The photocrosslinking double-modified silk fibroin-gelatin composite bio-ink is good in biocompatibility; the cross-linking of the bio-ink can be enhanced by a two-component modification method, and the bio-ink has temperature sensitivity and shear thinning, and can be used as 3D printing bio-ink to construct a personalized macroporous support to meet various needs.
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Description

technical field

[0001] The invention belongs to the field of tissue engineering scaffolds, in particular to a photo-crosslinked double-modified silk fibroin-gelatin composite biological ink and its preparation method and application. Background technique

[0002] Tissue engineering technology has the potential to fundamentally solve tissue and organ damage and realize its functional reconstruction. It is one of the common treatment strategies for bone substitute transplantation, and individual differences in patients are one of the key factors affecting the repair effect. Therefore, the preparation has Functional tissue engineering scaffolds that can adapt and match the injury site are an important part of this strategy. 3D printing technology is an additive manufacturing technology based on precision and speed. 3D printing technology is an additive manufacturing technology based on precision and speed. 3D printing technology can well solve the problem of implanted stents an...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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