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A set of biomarkers for diagnosing AD in a subject or determining a risk of the AD in the subject and an application thereof

A technology of biomarkers and subjects, applied in the field of biomarkers, achieves the effect of high accuracy, less trauma, and good application prospects

Active Publication Date: 2019-10-15
FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no relevant report about the biomarkers and their application for diagnosing AD in a subject or determining the risk of developing AD in a subject according to the present invention

Method used

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  • A set of biomarkers for diagnosing AD in a subject or determining a risk of the AD in the subject and an application thereof
  • A set of biomarkers for diagnosing AD in a subject or determining a risk of the AD in the subject and an application thereof
  • A set of biomarkers for diagnosing AD in a subject or determining a risk of the AD in the subject and an application thereof

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Experimental program
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Embodiment 1

[0040] This study studied the AD-related plasma metabolome based on the metabolomics method, aiming to study the pathogenesis of AD from the perspective of metabolic reprogramming and discover potential biomarkers. By collecting plasma samples from AD patients, mild cognitive impairment (MCI), non-AD neurological disease (NDC) patients and matched healthy people (Ctrl). The metabolome was analyzed by a non-targeted metabolomics method based on ultra-high performance liquid chromatography coupled with mass spectrometry. Using multivariate and univariate statistical analysis, pathway enrichment analysis to reveal metabolic changes related to AD pathogenesis and course, combined with correlation analysis to study the correlation between metabolic signatures and patients' clinical parameters.

[0041] 1 information

[0042] 1.1 Inclusion criteria of patients in the AD group

[0043] (1) Refer to the diagnostic criteria for dementia in the Diagnostic and Statistical Manual of Menta...

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Abstract

The invention relates to a set of biomarkers for diagnosing AD in a subject or determining a risk of the AD in the subject. Diagnostic markers are a cholic acid, a chenodeoxycholic acid, an allocholicacid, a benzpyrole-3-lactic acid and tryptophan. The invention also provides the application of the above diagnostic markers in preparation of a differential diagnostic reagent for an Alzheimer's disease and a kit. Plasma fingerprint spectrum analysis of AD patients, MCI patients, Ctrl and NDC populations is performed through a plasma sample collection-plasma sample pretreatment-ultra-high performance liquid chromatography and mass spectrometry analysis method, and contents of the above five diagnostic markers are detected so that the markers are applied to preparation of products related todiagnosis of the Alzheimer's disease, and therapeutic evaluation. The markers can evaluate an early phase of the Alzheimer's disease, accuracy is high, a detection speed is fast, cost is low, traumasare small, and patients can easily accept. A scientific and effective treatment plan is provided for the Alzheimer's disease and a good application prospect is possessed.

Description

technical field [0001] The present invention relates to the technical field of biomarkers, specifically, a group of biomarkers for diagnosing AD in a subject or determining the risk of developing AD in a subject and applications thereof. Background technique [0002] Alzheimer's disease (AD) is a primary degenerative disease of the central nervous system and the most common type of dementia. The main clinical symptom of AD is slow cognitive decline, including progressive loss of memory, logical reasoning ability and language function, and finally develops into severe dementia. The biggest risk factor for AD is age. With the aging population in my country, the incidence of AD is increasing, but the pathogenesis of AD is still unclear, and there is a lack of effective clinical diagnostic markers. In addition, a large amount of evidence shows that AD has extensive pathological changes in the brain before the diagnosis of AD, that is, before the symptoms of the patient appear....

Claims

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Application Information

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IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 乐卫东邵亚平李天白许国旺李崧许慧程诚
Owner FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV
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