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Ionization device, mass spectrometer, ion mobility spectrometer and ionization method

An ionization and ionization part technology, applied in the field of mass spectrometry or ion mobility spectrometry instruments, can solve the problems of large heat loss, low analysis sensitivity, and high requirements for working environment conditions, achieve fast heating and cooling speeds, improve analysis throughput, The effect of shortening the analysis time

Active Publication Date: 2019-10-29
SHIMADZU RES LAB SHANGHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The heating channel used in this device uses heat radiation or heat convection to heat the probe, the heating efficiency is low and it is difficult to obtain a high heating rate and temperature upper limit
Moreover, for portable instruments that are sensitive to power consumption, the heat loss of this solution is relatively large, and it is difficult to popularize and use it.
In addition, the heating channel in this device is easy to be polluted, which will cause memory effect and affect the analysis of samples
[0011] Therefore, the thermal desorption and ionization devices in the prior art have problems such as high requirements for working environment conditions, complex operation of devices and structures, low analytical sensitivity, poor reproducibility, etc. Technical solutions

Method used

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  • Ionization device, mass spectrometer, ion mobility spectrometer and ionization method
  • Ionization device, mass spectrometer, ion mobility spectrometer and ionization method
  • Ionization device, mass spectrometer, ion mobility spectrometer and ionization method

Examples

Experimental program
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Embodiment approach 1

[0059] This embodiment first provides an ionization device, which is applied to a mass spectrometer, and its structure is as follows figure 2 As shown, the mass spectrometer includes an ionization device 200 and an analysis assembly 204, wherein the ionization device includes a sampling desorption part 200A and an ionization part 200B, wherein the sampling desorption part 200A includes a sampling probe 201 and a heating assembly 202, wherein the sampling probe 201 is detachable from the sampling and desorption unit 200A, the user can take off the sampling probe 201, directly touch the sample by touching, dipping, soaking, wiping, etc., and then put it back to complete the sampling operation. Active sampling of the sample can also be performed by driving the sampling probe 201 to move to the sample by a probe driving unit (not shown). This structural design can make the sampling process more convenient and fast, and enables the ionization device 200 in this embodiment to perfo...

Embodiment approach 2

[0077] This embodiment provides an ionization device applied to a direct analysis mass spectrometer and a direct analysis mass spectrometer using the ionization device. continue to refer figure 2 , the mass spectrometer of this embodiment includes an ionization device 200 and an analysis assembly 204, wherein the ionization device 200 includes a sampling desorption part 200A and an ionization part 200B, wherein the sampling desorption part 200A includes a sampling probe 201 and a heating assembly 202, wherein the sampling The tail of the probe 201 is detachably installed on the sampling desorption part 200A. The heating component 202 is a DC power supply, which can heat the sampling probe 201 under atmospheric pressure, and by adjusting the output power of the DC power supply as the heating component 202, the sampling probe 201 can quickly heat up, so that the heated sample can be quickly removed from the sampling probe. The surface of the needle 201 is desorbed to form a mo...

Embodiment approach 3

[0105] refer to Figure 4 The ionization device and the direct analysis mass spectrometer provided in this embodiment are different from the ionization device and mass spectrometer in Embodiment 2. The main difference is that the heating assembly 402 in this embodiment further includes a temperature detection unit 406 and The temperature control part 407, the temperature detection part is the temperature sensor 406 that is arranged near the position of the sampling probe 401, and the temperature sensor 406 can collect a signal from the sampling probe 401 that can reflect its temperature, such as a heat radiation signal, and convert it In order to transmit the electrical signal to the temperature control unit 407, the temperature control unit 407 can determine the real-time temperature of the sampling probe 401 according to the electrical signal. At the same time, the temperature control unit 407 also has a calculation function, which can determine an appropriate temperature co...

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Abstract

The invention relates to the field of mass spectrometry and / or ion mobility spectrometers, and provides an ionization device, and a mass spectrometer and an ion mobility spectrometer having the ionization device, and also provides an ionization method. A sampling probe of the ionization device can actively and rapidly collect samples; through the integration of a sampling device and a thermal desorption device, the sampling device can be more concise and compact; and an ionization part is arranged at the downstream of a sampling desorption part, so that the sampling probe can be ensured to notinterfere in a flow field or electric field between the ionization part and an analysis assembly inlet, and therefore, the signal reappearance and analysis sensitivity of the device can be guaranteed.

Description

technical field [0001] The invention relates to the field of mass spectrometry or ion mobility spectrometry instruments, and more specifically, the invention relates to a device for ionizing samples of mass spectrometry or ion mobility spectrometry. Background technique [0002] With the wide application of liquid chromatography-mass spectrometry systems in the analysis of complex mixtures, ion sources working under atmospheric pressure, such as electrospray ionization sources and atmospheric pressure chemical ionization sources, have been put into use in the fields of food safety, environmental protection and national security. However, a large amount of time in the analysis process is spent in the pretreatment process before the sample is introduced into the analysis system, which hinders the further promotion and application of ion analysis technology in the industrial and commercial fields. [0003] In recent years, with desorption electrospray ionization (Desorption Ele...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/04H01J49/00
CPCH01J49/049H01J49/0413H01J49/0031H01J49/10G01N27/626
Inventor 程玉鹏孙文剑
Owner SHIMADZU RES LAB SHANGHAI
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