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Preparation method of cannabidiol by using industrial hemp as raw material

A technology for industrial hemp and cannabidiol, applied in the biological field, can solve the problems of waste and low content, and achieve the effects of avoiding waste, high extraction purity and saving time

Pending Publication Date: 2019-11-12
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Cannabidiol (CBD) is generally high in the top flowers, leaves and buds of industrial hemp. From the top to the root of the industrial hemp plant, the CBD content decreases by an order of magnitude. Therefore, factories generally only target the flowers, leaves and buds of industrial hemp For the extraction of CBD, the extraction process developed is also generally applicable to the flower leaves and buds of hemp; among them, the content of CBD in the leaves of industrial hemp is also 1%-3%, which is relatively low and has not been developed and utilized on a large scale, resulting in great waste

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0025] A preparation method of cannabidiol using industrial hemp as raw material, comprising the following steps:

[0026] Step 1: take more than one-third of the leaves of the industrial hemp plant, dry and crush them to obtain industrial hemp powder with a particle size of 40 mesh; the drying temperature is 70°C, and the moisture content of the leaves is less than 5%;

[0027] Step 2: Put the industrial hemp powder into the tunnel-type ultrasonic and heating extraction equipment, use absolute ethanol as the solvent, and extract to obtain the crude CBD extract, wherein the solid-liquid ratio of the industrial hemp powder to the solvent is 1 : 4, the ultrasonic power is 3000W, the extraction temperature is 80°C, and the extraction time is 3h;

[0028] Step 3: Put the CBD crude extract into a double-effect rising membrane concentration tank and concentrate to 1 / 16 of the volume of the CBD crude extract to obtain a CBD concentrate. The vacuum degree of the double-effect rising m...

specific Embodiment approach 2

[0033] A preparation method of cannabidiol using industrial hemp as raw material, comprising the following steps:

[0034] Step 1: take more than one-third of the leaves of the industrial hemp plant, dry and pulverize them to obtain industrial hemp powder with a particle size of 200 mesh; the drying temperature is 95°C, and the moisture content of the leaves is less than 5%;

[0035] Step 2: Put the industrial hemp powder into the tunnel-type ultrasonic and heating extraction equipment, use methanol as the solvent, and extract the crude CBD extract, wherein the solid-liquid ratio of the industrial hemp powder to the solvent is 1:30 , the ultrasonic power is 5000W, the extraction temperature is 95°C, and the extraction time is 2h;

[0036] Step 3: Put the CBD crude extract into a double-effect rising membrane concentration tank and concentrate to 1 / 20 of the volume of the CBD crude extract to obtain a CBD concentrate. The vacuum degree of the double-effect rising membrane conce...

specific Embodiment approach 3

[0041] A preparation method of cannabidiol using industrial hemp as raw material, comprising the following steps:

[0042] Step 1: take more than one-third of the leaves of the industrial hemp plant, dry and crush them to obtain industrial hemp powder with a particle size of 100 mesh; the drying temperature is 80°C, and the moisture content of the leaves is less than 5%;

[0043] Step 2: Put the industrial hemp powder into the tunnel-type ultrasonic and heating extraction equipment, use anhydrous ethanol and methanol mixed in any proportion as the solvent, and extract to obtain the crude CBD extract, wherein the industrial hemp powder and the solvent The solid-liquid ratio is 1:10, the ultrasonic power is 4000W, the extraction temperature is 85°C, and the extraction time is 2.5h;

[0044] Step 3: Put the CBD crude extract into a double-effect rising membrane concentration tank and concentrate to 1 / 18 of the volume of the CBD crude extract to obtain a CBD concentrate. The vacuu...

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Abstract

The invention provides a preparation method of cannabidiol by using industrial hemp as a raw material, and belongs to the field of biotechnology. The specific scheme is as follows: the preparation method of cannabidiol by using industrial hemp as the raw material comprises the following steps: step 1: taking leaves at one-third or more of the upper end of industrial hemp plants, and performing oven-drying and crushing to obtain an industrial hemp powder; step two: using absolute ethanol and / or methanol as a solvent, extracting the industrial hemp powder to obtain a CBD crude extraction liquid;step 3: concentrating the CBD crude extraction liquid to obtain a CBD concentration liquid; step 4: performing oil bath treatment on the CBD concentration liquid, removing volatile matters, and thenadding ethanol and / or methanol into bottom matters for re-dissolving to obtain a CBD solution with a purity of 20%-30%; step 5: adding the CBD solution into a chromatographic column, and performing eluting with dichloromethane and / or n-hexane to obtain a CBD chromatographic liquid; and step 6: concentrating the CBD chromatographic liquid to obtain a CBD concentration liquid with a purity of 60%-80%.

Description

technical field [0001] The invention belongs to the field of biotechnology, in particular to a method for preparing cannabidiol from industrial hemp. Background technique [0002] Marijuana (Cannabis sativa L.) belongs to the Moraceae cannabis plant, also known as hemp, hemp, jute, etc. Cannabis contains a secondary metabolite of hallucinogenic addiction - tetrahydrocannabinol (THC) , which can be used as a drug, was banned for a long time. Due to the high economic and medicinal value of marijuana, the varieties with THC content less than 0.3% in the flowers and leaves of marijuana during the growth period are called industrial hemp, which has no drug use value and can be legally used for large-scale cultivation and industrial development. [0003] Industrial hemp contains cannabidiol (CBD), which is a non-addictive ingredient. Cannabidiol has anti-inflammatory, bactericidal, labor pain, anti-epilepsy, anti-anxiety, blocking breast cancer metastasis and treating neonatal hy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C37/68C07C37/72C07C37/74C07C37/82C07C39/23
CPCC07C37/004C07C2601/16C07C39/23
Inventor 王振宇张华张胜宇辛超王佳慧
Owner HARBIN INST OF TECH
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