Preparation method of photoelectrochemical 17 beta-estradiol aptamer sensor based on indium sulfide and cadmium sulfide co-sensitized cerium-doped titanium dioxide

An aptamer sensor, titanium dioxide technology, applied in the direction of electrochemical variables of materials, etc., can solve the problems of not easy to capture biological antibodies, small molecular weight, etc., and achieve the effect of reducing electron-hole recombination rate, good photoelectric performance, and wide signal response range.

Active Publication Date: 2019-11-12
UNIV OF JINAN
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  • Application Information

AI Technical Summary

Problems solved by technology

Endocrine disruptors generally have a smaller molecular weight tha

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment example 1

[0033] Embodiment 1 Preparation of cerium-doped titanium dioxide

[0034]Dissolve 1 mL of n-butyl titanate in 40 mL of ethanol to obtain solution A; weigh 9.3 mg of cerium nitrate hydrate and dissolve in water to obtain solution B; drop solution A into solution B at room temperature, and vigorously After stirring for 30 min, it was transferred to a reactor and reacted at 180°C for 12 h. After the reaction, it was cooled down to room temperature naturally, washed with ethanol and deionized water several times, and dried at 80 °C to obtain cerium-doped titanium dioxide nanoparticles.

Embodiment example 2

[0035] Preparation of Example 2 Cerium-doped Titanium Dioxide

[0036] Dissolve 1 mL of n-butyl titanate in 40 mL of ethanol to obtain solution A; weigh 3.1 mg of cerium nitrate hydrate and dissolve it in water to obtain solution B; drop solution A into solution B at room temperature, vigorously After stirring for 30 min, it was transferred to a reactor and reacted at 180°C for 12 h. After the reaction, it was cooled down to room temperature naturally, washed with ethanol and deionized water several times, and dried at 80 °C to obtain cerium-doped titanium dioxide nanoparticles.

Embodiment example 3

[0037] Example 3 Preparation of Cerium-doped Titanium Dioxide

[0038] Dissolve 1 mL of n-butyl titanate in 40 mL of ethanol to obtain solution A; weigh 1.6 mg of cerium nitrate hydrate and dissolve in water to obtain solution B; drop solution A into solution B at room temperature, and vigorously After stirring for 30 min, it was transferred to a reactor and reacted at 180°C for 12 h. After the reaction, it was cooled down to room temperature naturally, washed with ethanol and deionized water several times, and dried at 80 °C to obtain cerium-doped titanium dioxide nanoparticles.

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Abstract

The invention relates to a preparation method of a photoelectrochemical 17 beta-estradiol aptamer sensor based on indium sulfide and cadmium sulfide co-sensitized cerium-doped titanium dioxide, and belongs to the field of photoelectrochemical sensors. According to the method, cerium-doped titanium dioxide is obtained by using a simple hydrothermal method to serve as a substrate material, and a light current is obtained; and for the cerium-doped titanium dioxide after indium sulfide sensitization, the photoelectric conversion efficiency is greatly improved, and the light absorption range is enlarged. Under the co-sensitization of cadmium sulfide, the positions of conduction bands of the three are reduced in a stepped mode, so that rapid transfer of electrons is facilitated, and an ideal light current signal is provided. The high-sensitivity detection of 17 beta-estradiol is realized by combining the specific recognition effect of an aptamer and the 17 beta-estradiol; the detection limitof the 17 beta-estradiol is 3.98 fg/mL; and the method has important significance in analysis and detection of the 17 beta-estradiol.

Description

technical field [0001] The invention belongs to the fields of novel functional nanometer materials, immune analysis and photoelectrochemical sensors, and relates to a method for preparing a photoelectrochemical 17β-estradiol aptamer sensor of indium sulfide and cadmium sulfide co-sensitized cerium-doped titanium dioxide. Background technique [0002] 17β-estradiol is a lipophilic, low-molecular-weight steroid hormone. It is the most estrogenic type of environmental endocrine disruptors, and even a small amount can affect the normal human endocrine system. 17β-estradiol can enter the environment through many ways, for example, pathological treatment, feed additives, excrement without complete metabolism, etc. Excessive 17β-estradiol will be transmitted to the human body along the food chain and accumulate in the human body, resulting in The chances of dysplasia, reproductive diseases and breast cancer are greatly increased, causing irreversible damage to the human body. Ther...

Claims

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Application Information

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IPC IPC(8): G01N27/30
CPCG01N27/30
Inventor 魏琴李月雯徐芮魏东冯锐范大伟张诺
Owner UNIV OF JINAN
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