Method for preparing acetophenone and its derivatives through selectively oxidizing ethylbenzene and its derivatives

A derivative, the technology of acetophenone, applied in the field of organic chemical industry and fine organic synthesis, can solve the problems of incomplete decomposition of peroxides, uneasy control of the reaction, high reaction temperature, etc., and achieve simple oxidation transformation, novel reaction mode, selective sex high effect
CN110498745AActive Publication Date: 2019-11-26ZHEJIANG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Publication Date
2019-11-26

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Abstract

The invention discloses a method for preparing acetophenone and its derivatives through selectively oxidizing ethylbenzene and its derivatives. The method comprises the following steps: putting ethylbenzene and its derivatives, a cobalt (II) salt catalyst, an oxidizing agent and a dispersant in an agate ball milling tank, sealing the ball milling tank, carrying out ball milling at room temperatureunder a rotating speed of 100-800 rpm for 3.0-24.0 h, stopping the ball milling one time every 1.0-3.0 h, and discharging a gas in the ball milling tank; and dissolving the obtained reaction mixturein anhydrous ethanol after the reaction is finished, performing stirring at room temperature, filtering the obtained solution, washing the obtained solid with anhydrous ethanol, mixing the obtained ethanol solutions, and making the volume reach a constant value. The method provided by the invention has the advantages of small catalyst dosage, no solvents, no heating, low reaction temperature, lessenergy consumption, convenience in operation, high acetophenone selectivity, no obvious peroxide residue, high safety factor, and realization of selective and safe oxidative conversion of ethylbenzene and its various derivatives.
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Description

[0001] (1) Technical field

[0002] The invention relates to a method for preparing acetophenone and its derivatives through selective oxidation of ethylbenzene and its derivatives, belonging to the fields of organic chemical industry and fine organic synthesis.

[0003] (2) Background technology

[0004] Acetophenone and its derivatives are an important class of fine chemical intermediates, widely used in the synthesis of fine chemical products and high-end intermediates such as pharmaceuticals, pesticides, dyes, and analytical and detection reagents (WO 201611034971; Bioorganic & Medicinal Chemistry Letters 2019, 29: 525-528; Bioorganic Chemistry 2019, 82:360-377; ACS Applied Materials & Interfaces 2018, 10:44324-44335). At present, the synthesis of acetophenone and its derivatives is mainly based on ethylbenzene, 1-phenylethanol, styrene and its derivatives as raw materials through oxidation reactions (US20190002487; CN 108947846; Molecular Catalysis 2019, 469: 27- 39; Orga...

Claims

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