A method for preparing acetophenone and its derivatives by selective oxidation of ethylbenzene and its derivatives

A derivative, the technology of acetophenone, applied in the field of organic chemical industry and fine organic synthesis, can solve the problems of incomplete decomposition of peroxides, uneasy control of the reaction, high reaction temperature, etc., and achieve simple oxidation transformation, novel reaction mode, selective sex high effect
CN110498745BActive Publication Date: 2022-06-17ZHEJIANG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Publication Date
2022-06-17

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Abstract

A method for preparing acetophenone and derivatives thereof by selective oxidation of ethylbenzene and derivatives thereof, wherein ethylbenzene and derivatives thereof, cobalt (II) salt catalyst, oxidizing agent and dispersant are placed in an agate ball mill jar, sealed ball mill Tank, room temperature, ball milling at 100-800rpm for 3.0-24.0h, stop the ball milling every 1.0-3.0h, release the gas in the ball milling tank; after the reaction is completed, dissolve the obtained reaction mixture in absolute ethanol, stir at room temperature, filter, Wash the obtained solid with absolute ethanol, and combine the obtained ethanol solutions to constant volume. The invention uses less catalyst, does not use solvent, does not need heating, has low reaction temperature, less energy consumption, convenient operation, high selectivity of acetophenone, no obvious peroxide residue detected, high safety factor, and various Selective, safe oxidative transformation of ethylbenzene and its derivatives.
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Description

(1) Technical field

[0001] The invention relates to a method for preparing acetophenone and its derivatives by selective oxidation of ethylbenzene and derivatives thereof, belonging to the fields of organic chemical industry and fine organic synthesis. (2) Background technology

[0002] Acetophenone and its derivatives are an important class of fine chemical intermediates, which are widely used in the synthesis of fine chemical products such as medicines, pesticides, dyes, analytical detection reagents, and high-end intermediates (WO 201611034971; Bioorganic&Medicinal Chemistry Letters 2019, 29: 525-528; Bioorganic Chemistry 2019, 82: 360-377; ACS Applied Materials & Interfaces 2018, 10: 44324-44335). At present, the synthesis of acetophenone and its derivatives mainly uses ethylbenzene, 1-phenethyl alcohol and styrene and their derivatives as raw materials, and is realized by oxidation reaction (US20190002487; CN 108947846; Molecular Catalysis 2019, 469: 27- 39; Organic Pr...

Claims

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