Micro-needle template, preparation method of micro-needle template, and method for preparing micro-needle array by using micro-needle template
A technology of microneedles and templates, applied in the field of microneedles, can solve the problems of uneven quality, high failure rate, and low efficiency of microneedles, and achieve the effect of overcoming the complexity of the preparation process and the uniform formation of microneedles
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Embodiment 1
[0031] like figure 1 As shown, the preparation method of the microneedle template of the present embodiment specifically includes:
[0032] Mix polydimethylsiloxane PDMS and curing agent Dow Corning sylgard 184 in a mass ratio of 10:1, and stir evenly; then place the mixture in a negative pressure environment of -0.09MPa to remove air bubbles;
[0033] Then heat to 80°C to solidify for 6 hours to solidify, and obtain a polydimethylsiloxane-based plate with a thickness of 700 μm after cooling;
[0034] Cut the polydimethylsiloxane-based plate into a length and width of 5cm×5cm to obtain a polydimethylsiloxane template of the target size; design the space between the centers of the microneedle cavities to be 600 μm, and the diameter of the upper surface of the cavity to be 260 μm. The diameter of the lower surface is 30 μm. Use drawing software to design the microneedle array and import it into the laser etching machine system. Set the laser energy parameters to 75W, speed 5mm / ...
Embodiment 2
[0045] The preparation method of the microneedle template of this embodiment specifically includes:
[0046] Mix polydimethylsiloxane and curing agent silane coupling agent in a mass ratio of 5:1, and stir evenly; then place the mixture in a negative pressure environment of -0.09MPa to remove air bubbles;
[0047] Then heat to 60°C to solidify for 1 hour to solidify, and obtain a polydimethylsiloxane-based plate with a thickness of 500 μm after cooling;
[0048] Cut the polydimethylsiloxane-based plate to a length and width of 1cm×1cm to obtain a polydimethylsiloxane template of the target size; design the space between the center of the microneedle cavity to be 200 μm, and the diameter of the upper surface of the cavity to be 100 μm. The diameter of the lower surface is 10 μm. Use the drawing software to design the microneedle array and import it into the laser etching machine system. Set the laser energy parameters as power 10W, speed 1mm / s, resolution 500, and z-axis 650 μm...
Embodiment 3
[0055] The preparation method of the microneedle template of this embodiment specifically includes:
[0056] Mix polydimethylsiloxane and curing agent silane coupling agent in a mass ratio of 20:1, and stir evenly; then place the mixture in a negative pressure environment of -0.09MPa to remove air bubbles;
[0057] Then heat to 90°C and solidify for 12 hours to solidify, and obtain a polydimethylsiloxane-based plate with a thickness of 1000 μm after cooling;
[0058] Cut the polydimethylsiloxane-based plate into a length and width of 50cm×50cm to obtain a polydimethylsiloxane template of the target size; design the space between the centers of the microneedle cavities to be 1000 μm, and the diameter of the upper surface of the cavity to be 600 μm. The diameter of the lower surface is 20 μm. Use the drawing software to design the microneedle array and import it into the laser etching machine system. Set the laser energy parameters as power 100W, speed 10mm / s, resolution 500, z-...
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