Phase change nano droplet regulation and control method based on spatially heterogeneous focused eddy sound filed

Abstract

The invention provides a phase change nano droplet regulation and control method based on a spatially heterogeneous focused eddy sound filed. The phase change nano droplet regulation and control method based on the spatially heterogeneous focused eddy sound filed comprises the steps that by adjusting relative power and a phase position among spherical focused ultrasonic transducer array elements,the heterogeneous focused eddy sound filed with symmetric distribution of sound pressure and a sound pressure maximum value existing on an annular antinode is generated, the heterogeneous focused eddysound filed is used for aggregating scattered phase change nano droplets to a micron-sized bulk droplet aggregate, so that a phase change threshold value of the phase change nano droplets is obviously reduced, a single microsecond short pulse is used for acting on the aggregated phase change nano droplets, then droplet phase change is induced, and the nano size distribution of the droplets in theaggregate ensures the vibration activity of phase change microvesicle. According to the phase change nano droplet regulation and control method based on the spatially heterogeneous focused eddy soundfiled, sound regulation and control of the phase change nano droplets under a living body condition has higher flexibility and safety.

Description

technical field [0001] The invention belongs to the fields of ultrasonic physics, ultrasonic detection and control, and in particular relates to a control method for phase-change nano-droplets based on a spatially non-uniform focused vortex sound field. Background technique [0002] In recent years, the spatiotemporal controllability of nanocarriers in the drug delivery process has attracted great attention in the fields of material chemistry and drug delivery, and various disciplines have also developed corresponding technologies and methods. The advantages of non-invasiveness and good penetration have become a hot spot in this research direction. Currently, in the field of ultrasound, phase-change nanodroplets composed of perfluorocarbons and envelopes (lipids, proteins, surfactants, etc.) have shown great potential in achieving spatiotemporal controlled release of drugs. Under the action of a certain intensity of ultrasound, the phase-change nano-droplets will undergo a ...

AI Technical Summary

Problems solved by technology

In the central region of the uniform vortex sound field, particles and microbubbles will be gathered in the low sound pressure region (ie, the node) of the vortex center to form cluster-like aggregates, and the phase-change nano-droplets will Under the action of acoustic radiation force, they will gather in the high-acoustic pressure band area (i.e., antinode) around the center of the vortex, forming a ring-like aggregation with a larger diameter, resulting in a lower degree of aggregation of phase-change nano-droplets under the action of a uniformly focused vortex sound field. , and it is not conducive to the precise control of the action area in droplet-assisted focused ultrasound therapy

However, there is no report on the manipulation of phase-change nano-droplets by using the focused vortex acoustic field.

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