Mesothelin detection cell quality control piece

A technology of cytoplasm and mesothelin, which is applied in the direction of biological testing, material inspection products, preparation of test samples, etc. It can solve the problems that there are no control cells with different expression intensities, and the control effect needs to be improved.
CN110531083APending Publication Date: 2019-12-03REMEGEN CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
REMEGEN CO LTD
Publication Date
2019-12-03

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Abstract

The invention relates to a mesothelin immunohistochemical detection cell quality control piece and a related detection reagent. The cell quality control piece comprises a sectioning area, wherein paraffin sections are adhered to the sectioning area, and the paraffin sections contain four kinds of cell clusters for expressing negative, weak positive, positive and strong positive properties of the mesothelin. The immunohistochemical detection cell quality control piece involved in the invention is mainly used for improving the accuracy and the consistency of immunohistochemical detection results, and has a high application prospect.
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Description

technical field

[0001] The invention relates to a cell or tissue sample control quality control sheet for immunohistochemical detection of mesothelin and related detection reagents. Background technique

[0002] Mesothelin (MSLN) is a membrane protein. The mesothelin gene encodes a 71KD preprotein, which is modified and cut into two segments, 40KD glycosylated phosphatidylinositol cell membrane-anchored protein and 31KD The free fragment is called megakaryocyte-promoting factor. Studies have confirmed that the 40KD membrane-anchored protein contains a binding region with another tumor marker CA125 protein, which may be related to cell adhesion, so it is speculated that it may contribute to the distant metastasis of primary cancer (such as peritoneal metastasis) , and lead to poor prognosis.

[0003] Although the function of Mesothelin is not yet clear, both the cell membrane binding region and the free region have been proven to be markers and therapeutic targets for vario...

Claims

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