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D-glucosamine tablet and preparation method thereof
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A glucosamine and tablet technology, applied in the field of medicine, can solve the problems of less effective drug content, low bioavailability, easy oxidation and discoloration of amino groups, etc., and achieves the effects of rapid dissolution, clean product quality, and not easy to deteriorate.
Inactive Publication Date: 2019-12-10
SHANDONG RUNDE BIOTECH CO LTD
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Problems solved by technology
[0003] However, glucosamine has many disadvantages as a drug, such as glucosamine is highly hygroscopic, and its amino group is easily oxidized and discolored. Therefore, the preparation requirements of glucosamine are relatively high, such as tablets need to be coated, packed in Capsule shells should be sealed and protected from moisture and oxygen
In addition, most of the commercially available glucosamine products have less effective drug content and low bioavailability
Method used
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Embodiment 1
[0027] In parts by weight, the D-glucosamine tablet of the present embodiment comprises 78 parts of D-glucosamine, 6 parts of fillers, 7 parts of disintegrants, 4 parts of wetting agents, 3 parts of simethicone, 3 parts of lubricant agent, 3 parts of starch.
[0032] In parts by weight, the D-glucosamine tablet of the present embodiment comprises 75 parts of D-glucosamine, 4 parts of fillers, 6 parts of disintegrants, 3 parts of wetting agents, 2 parts of simethicone, 2 parts of lubricant agent, 2 parts of starch.
[0033] Wherein, the filler is pregelatinized starch and lactose, and the mass ratio of pregelatinized starch and lactose is 20:3.
[0034] The disintegrating agent is croscarmellose sodium and carboxymethyl starch sodium, and the mass ratio of croscarmellose sodium to carboxymethyl starch sodium is 11:1.
[0037] In parts by weight, the D-glucosamine tablet of the present embodiment comprises 80 parts of D-glucosamine, 8 parts of fillers, 8 parts of disintegrants, 5 parts of wetting agents, 4 parts of simethicone, 4 parts of lubricant agent, 3 parts of starch.
[0038] Wherein, the filler is pregelatinized starch and lactose, and the mass ratio of pregelatinized starch and lactose is 4:1.
[0039] The disintegrating agent is croscarmellose sodium and carboxymethyl starch sodium, and the mass ratio of croscarmellose sodium to carboxymethyl starch sodium is 13:1.
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Abstract
The invention belongs to the field of medicine, and discloses a D-glucosamine tablet and a preparation method thereof. The D-glucosamine tablet comprises, by weight, 75-80 parts of D-glucosamine, 4-8parts of a filling agent, 6-8 parts of a disintegrating agent, 3-5 parts of a wetting agent, 2-4 parts of a glidant, 2-4 parts of a lubricating agent, and 2-3 parts of starch. Preferably, in the filling agent, the mass ratio of pregelatinized starch and lactose is 10:(1.5-2.5), the disintegrating agent comprises croscarmellose sodium and sodiumcarboxymethyl starch, and the mass ratio of croscarmellose sodium and sodiumcarboxymethyl starch is (5.5-6.5):1. In the D-glucosamine tablet, the content of D-glucosamine reaches 70%, human-body absorption is not influenced, D-glucosamine rapidly dissolves out, the bioavailability is high, and the stability is good.
Description
technical field [0001] The invention relates to the field of medicine, in particular to a D-glucosamine tablet and a preparation method thereof. Background technique [0002] Glucosamine is a natural amino monosaccharide, which is a physiologically active substance that can stimulate chondrocytes to produce proteoglycan and collagen with a normal multimer structure, and is an essential substance for the synthesis of proteoglycan in joints. Glucose can inhibit the enzymes that damage cartilage such as collagenase and phospholipase A2, and can prevent the production of superoxide free radicals that damage cells. At the same time, it does not inhibit the biosynthesis of prostaglandins. The pathological process of arthritis, preventing disease progression, improving joint mobility, relieving pain, and without significant side effects. Non-steroidal anti-inflammatory drugs only relieve symptoms and have no blocking effect on the process of osteoarthritis. Some drugs such as indo...
Claims
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Application Information
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