Check patentability & draft patents in minutes with Patsnap Eureka AI!

Preparation method of vitamin B12

A technology of B12 and vitamins, which is applied in the fields of medicine and chemical industry, can solve the problems of increasing production costs and environmental protection costs, large fluctuations in the quality of acetone crystallization, and high solvent consumption, and achieve the effects of improving resin utilization, shortening working hours, and reducing safety risks

Active Publication Date: 2019-12-13
华北制药河北莱欣药业有限公司
View PDF6 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing vitamin B12 is mainly obtained by adding acetone to change the solubility of the feed liquid in the crystallization process, but the solvent consumption of the acetone crystallization process is high, the recovery cost is high, and the safety risk is large, which increases the production cost and environmental protection cost. At the same time, the acetone crystallization process has quality Disadvantages such as large fluctuations

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of vitamin B12
  • Preparation method of vitamin B12
  • Preparation method of vitamin B12

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0027] The invention discloses a preparation method of vitamin B12. The invention adopts the vitamin B12 fermented liquid to obtain the filtrate through filtration. The filtrate is absorbed, eluted and concentrated through the cation resin column, and then the conversion agent is added, and the temperature rise reaction is used to obtain the vitamin B12 conversion liquid. Then the vitamin B12 conversion solution is used as a raw material to carry out the following steps:

[0028] (1) Adsorb and wash the vitamin B12 conversion solution through the resin column at a flow rate of 0.2 to 0.7 BV / H;

[0029] (2), analyze the resin column that has adsorbed vitamin B12 with a certain concentration of resolving agent;

[0030] (3), the vitamin B12 concentrated solution analyzed in step 2 is added to a rotary evaporator for temperature-controlled concentration, and the temperature-controlled temperature is 60-70° C.;

[0031] (4), the concentrated solution of vitamin B12 after the step...

Embodiment 1

[0039] This embodiment uses above-mentioned method to prepare vitamin B12, comprises the following steps:

[0040] (1), the vitamin B12 conversion solution is adsorbed by the 288 resin column packed in 100ml at a flow rate of 0.5BV / H, and washed with water at a flow rate of 0.5BV / H after the adsorption is completed;

[0041] (2), be that the 330ml acetone resolving agent of 15% is analyzed the resin column that has adsorbed vitamin B12 with concentration;

[0042] (3), take out 1000ml of the vitamin B12 purification solution analyzed in step 2 and add it to a rotary evaporator for temperature-controlled concentration, and the temperature-controlled temperature is about 65°C;

[0043] (4), the concentrated solution of vitamin B12 after step 3 is concentrated is passed through 900 purification column with 3BV / H;

[0044] (5), adding the vitamin B12 concentrated solution purified in step 4 to the rotary evaporator again for temperature-controlled concentration, and the temperatu...

Embodiment 2

[0052] Include the following steps:

[0053] (1), the vitamin B12 conversion solution is adsorbed by the 288 resin column packed in 100ml at a flow rate of 0.5BV / H, and washed with water at a flow rate of 0.5BV / H after the adsorption is completed;

[0054] (2), be that the 330ml acetone resolving agent of 15% is analyzed the resin column that has adsorbed vitamin B12 with concentration;

[0055] (3), take out 1000ml of the vitamin B12 purification solution analyzed in step 2 and add it to a rotary evaporator for temperature-controlled concentration, and the temperature-controlled temperature is 65°C;

[0056] (4), the concentrated solution of vitamin B12 after step 3 is concentrated is passed through 900 purification column with 3BV / H;

[0057] (5), adding the vitamin B12 concentrated solution purified in step 4 to the rotary evaporator again for temperature-controlled concentration, and the temperature-controlled temperature is about 65°C;

[0058] (6), the purification sol...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a preparation method of vitamin B12, and belongs to the technical fields of chemical engineering and medicine. According to the method, the vitamin B12 conversion solution isadsorbed, washed with water and desorbed through resin to obtain a vitamin B12 purified solution, then temperature-controlled concentration and stirring cooling are performed, suction filtration is performed after the temperature is reduced to a proper temperature to obtain wet crystals, and the obtained wet crystals are subjected to vacuum constant-temperature drying to obtain a finished product.The method has the effects of simple operation, energy saving and environmental protection, the vitamin B12 wet crystals obtained by a solvent-free method is low in impurity content and stable in quality, and the production and environmental protection costs are greatly reduced while green production is ensured.

Description

technical field [0001] The invention relates to a preparation method of vitamin B12, which belongs to the technical fields of chemical industry and medicine. Background technique [0002] Vitamin B12, referred to as VB12, also known as cobalamin, vitamin B12 in nature is synthesized by microorganisms, and higher animals and plants cannot produce vitamin B12. In the fields of health food and injections, as the safety requirements of food and medicine are getting higher and higher, vitamin B12 is more and more widely used. Correspondingly, the preparation and production of high-purity vitamin B12 has gradually become an inevitable requirement of technological development and a large number of technical personnel. goal of effort. [0003] The existing vitamin B12 is mainly obtained by adding acetone to change the solubility of the feed liquid in the crystallization process, but the solvent consumption of the acetone crystallization process is high, the recovery cost is high, a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07H1/06C07H23/00
CPCC07H1/06C07H23/00
Inventor 程俊山柳永宁李建强胡斌江虹韩柱郭文仿杨继宗顾晓菲潘丽红赵静张苗静朱军志张亚丽王勇
Owner 华北制药河北莱欣药业有限公司
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com