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Metabolic markers related to low-grade glioma in urine and application of metabolic markers

A metabolic marker, low-level technology, applied in the field of metabolic markers, can solve the problems of lack of specific early symptoms, poor surgical treatment effect, hidden onset of glioma, etc.

Active Publication Date: 2019-12-13
THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, the onset of glioma is insidious and lacks specific early symptoms, which leads to the fact that the tumor is often discovered in the later stage of the tumor course. At this time, the tumor is large and invasive, and the effect of surgical treatment is often poor.

Method used

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  • Metabolic markers related to low-grade glioma in urine and application of metabolic markers
  • Metabolic markers related to low-grade glioma in urine and application of metabolic markers
  • Metabolic markers related to low-grade glioma in urine and application of metabolic markers

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Embodiment 1

[0041] Example 1: Screening and identification of low-grade glioma-related metabolites in urine

[0042] We used liquid chromatography-high resolution mass spectrometry (LC-MS) to detect metabolites in urine in full-scan mode, and screened metabolites associated with low-grade gliomas (oligodendroglioma, astrocytoma) by multivariate statistical analysis. thing. The identification of metabolic markers is carried out by the matching or analysis of the secondary fragments using the secondary targeted analysis method.

[0043] Materials and Reagents

[0044] 1) Instrument: Waters H-class liquid chromatograph (waters company) LTQ-Orbitrapvelos pro mass spectrometer (Thermofisher Scientific company).

[0045] 2) Main reagents: acetonitrile (Thermofisher Scientific Company); C18 reverse-phase chromatographic column (3.0 mm×100 mm, C18, 1.7 μm, Waters Company).

[0046] 3) Samples: urine from 45 patients with low-grade glioma (oligodendroglioma, astrocytoma) and 65 age- and gender-...

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Abstract

The invention discloses metabolic markers related to low-grade glioma in urine and application of the metabolic markers. Specifically, in contrast to normal healthy people, the contents of metabolic markers including chenodeoxycholic sulfate, tyramine-oxygen-sulfate, glycochenodeoxycholic 3-glucosiduronide and aspartyl-leucine in urine of a low-grade glioma patient areincreased, and the contents of 2-hydroxy-ethyl sebacate, a deoxycholic acid and glycine conjugate and testosterone glucuronide are reduced. Therefore, an identification reagent of the metabolic markers related to the low-grade glioma can be used for preparing a product for diagnosis and / or prognosis of the low-grade glioma, the identification reagent is a mass spectrum identification reagent of the metabolic markers, and massspectrum identification is used under combination of mass spectrum full-scanning mode screening and secondary targeting identification; and the product is preferably used for early diagnosis of low-grade glioma.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to metabolic markers related to low-grade glioma in urine and applications thereof. Background technique [0002] According to the latest yearbook of the Ministry of Health of China in 2013, more than 300,000 patients die of brain tumors nationwide every year. The 2018 report of the American Center for Brain Tumor Registry (Q.T.Ostrom, et al., CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011-2015. Neuro Oncol 20 (2018) iv1-iv86) pointed out that, Glioma (glioma) is the most common primary malignant tumor of the brain, accounting for 81% of all primary brain malignant tumors, with a high degree of malignancy and poor treatment effect. After standard surgery, radiotherapy and chemotherapy, the median survival period of glioblastoma (GBM) patients is only 14.6 months (R.Stupp, et al., Radiotherapy plus concomit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/574G01N30/88
CPCG01N30/88G01N33/57484G01N33/6848G01N2030/8818G01N2030/8831
Inventor 孙伟刘晓燕汤晓悦孙海丹郭正光李京刘响
Owner THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
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