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A kind of preparation method and application of fucoidan rich in fucoidan and sodium alginate

A technology of sodium alginate and fucoidan, which is applied in allergic diseases, drug combinations, digestive system, etc., can solve the problems of low yield, cumbersome preparation process, and large loss of components, and achieve the purpose of regulating the gastrointestinal tract, Reduced separation process and product safety effects

Active Publication Date: 2021-10-15
青岛明月海琳岩藻多糖生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, with the existing technology, it is difficult to ensure that sodium alginate and fucoidan are retained as much as possible during the extraction and separation process, and there are still problems such as cumbersome preparation process, large loss of components, and low yield.

Method used

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  • A kind of preparation method and application of fucoidan rich in fucoidan and sodium alginate
  • A kind of preparation method and application of fucoidan rich in fucoidan and sodium alginate

Examples

Experimental program
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Effect test

Embodiment 1

[0045] (1) Steam explosion

[0046] Cut the dry kelp to 3cm in length and 2cm in width, put 2kg of dry material into the steam explosion test device, carry out steam explosion treatment under the pressure of 1.3Mpa for 2min, and collect 1.84kg of steam explosion material;

[0047] (2) One enzymatic hydrolysis

[0048]Add 10kg of water to the above dry material, adjust the pH value to 4.9, then add 100g of cellulase and pectinase, and carry out the degradation reaction at 45°C for 10 hours, and the fucoidan is released from the cell into the solution to obtain a solid-liquid mixed system;

[0049] (3) Conversion

[0050] Add hydrochloric acid to the above solid-liquid mixing system, adjust the pH value to 3.5, slowly add 200g of sodium carbonate, keep the temperature at 25°C, and stir for 0.5h to convert alginic acid into sodium alginate, reducing the alkali of fucoidan after the reaction Sexual precipitation; 25 ~ 40 ℃ is beneficial to increase the proportion of fucoidan st...

Embodiment 2

[0063] (1) Steam explosion

[0064] Cut the dry kelp to 3cm in length and 2cm in width, put 2kg of dry material into the steam explosion test device, carry out steam explosion treatment under the pressure of 1.3Mpa for 2min, and collect 1.84kg of steam explosion material;

[0065] (2) One enzymatic hydrolysis

[0066] Add 10kg of water to the above dry material, adjust the pH value to 4.9, then add 100g of cellulase and pectinase, and carry out the degradation reaction at 40°C for 12 hours, and the fucoidan is released from the cell into the solution to obtain a solid-liquid mixed system;

[0067] (3) Conversion

[0068] Add hydrochloric acid to the above solid-liquid mixing system, adjust the pH value to 2.9, slowly add 200g of sodium carbonate, keep the temperature at 40°C, and stir for 0.5h to convert alginic acid into sodium alginate, reducing the alkali of fucoidan after the reaction Sexual precipitation; 25 ~ 40 ℃ is beneficial to increase the proportion of fucoidan s...

Embodiment 3

[0080] (1) Steam explosion

[0081] Cut the dry kelp to 3cm in length and 2cm in width, put 2kg of dry material into the steam explosion test device, carry out steam explosion treatment under the pressure of 1.3Mpa for 2min, and collect 1.84kg of steam explosion material;

[0082] (2) One enzymatic hydrolysis

[0083] Add 10kg of water to the above dry material, adjust the pH value to 4.9, then add 100g of cellulase and pectinase, and carry out the degradation reaction at 45°C for 10 hours, and the fucoidan is released from the cell into the solution to obtain a solid-liquid mixed system;

[0084] (3) Conversion

[0085] Add hydrochloric acid to the above solid-liquid mixing system, adjust the pH value to 3.5, slowly add 200g of sodium carbonate, keep the temperature at 30°C, and stir for 0.5h to convert alginic acid into sodium alginate, reducing the alkali of fucoidan after the reaction Sexual precipitation; 25 ~ 40 ℃ is beneficial to increase the proportion of fucoidan s...

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Abstract

The invention discloses a preparation method of fucoidan rich in fucoidan and sodium alginate, relates to the technical field of polysaccharide preparation, and comprises the following steps: (1) steam explosion; (2) primary enzymatic hydrolysis; (3) transformation (4) solid-liquid separation; (5) ion exchange; (6) secondary enzymatic hydrolysis; (7) membrane filtration; (8) decolorization and concentration. The present invention uses steam explosion combined with enzymatic hydrolysis technology to release the content of algae to the greatest extent, and obtains fucoidan rich in fucoidan and sodium alginate through purification and separation technology, which reduces the concentration of fucoidan and sodium alginate. The separation process simplifies the preparation process, reduces the loss of components, and improves the yield; removes heavy metals, making the product safer; removes fishy substances such as proteins, and improves the acceptability of the product; increases the content of high sulfuric acid groups in the product The proportion of fucoidan structure strengthens the gastrointestinal maintenance function.

Description

technical field [0001] The invention relates to the technical field of polysaccharide preparation technology, in particular to a preparation method and application of fucoidan rich in fucoidan and sodium alginate. Background technique [0002] Fucoidan mainly includes three types of alginic acid, fucoidan, and fucoidan. Fucoidan can be degraded into monosaccharide components in the body. Alginic acid and fucoidan are not absorbed and utilized by the human body, and can be widely used in functional foods and other fields. . [0003] At present, for the extraction of sodium alginate and fucoidan, the overall idea is to continuously separate the target components through certain purification techniques. Chinese patent CN1927889A discloses a process for extracting fucoidan by comprehensive utilization of kelp. By soaking and washing the kelp, the soaking liquid and washed kelp are obtained. The fucoidan in the soaking liquid is precipitated by graded alcohol, and impurities rem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/04C08B37/00A61P1/00A61P37/02
CPCA61P1/00A61P37/02C08B37/0003C08B37/0084
Inventor 尹宗美王暖升王文丽刘俊霞王超
Owner 青岛明月海琳岩藻多糖生物科技有限公司