Eucomman strontium complex and preparation method and application thereof

A technology of eucommia polysaccharides and complexes, which is applied in the field of biomedicine and can solve problems such as toxicity and difficulty in the development of strontium applications

Active Publication Date: 2019-12-24
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
View PDF3 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Strontium plays an important role in the formation of bones. Strontium can promote the proliferation of osteoblasts and pluripotent stem

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Eucomman strontium complex and preparation method and application thereof
  • Eucomman strontium complex and preparation method and application thereof
  • Eucomman strontium complex and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0029] Such as figure 1 Shown, the preparation method of the Eucommia polysaccharide strontium complex of one embodiment, comprises the steps:

[0030] Step S110: Under the condition of controlling the pH to 9-11, react Eucommia polysaccharide and water-soluble strontium salt in water to obtain a reaction liquid.

[0031] By controlling the pH to be 9-11, the reaction can be carried out smoothly, and the strontium complex of Eucommia polysaccharide is generated.

[0032] Specifically, the mass molar ratio of the Eucommia polysaccharide to the strontium element in the water-soluble strontium salt is 60g:1mol˜250g:1mol. Too much strontium element will cause a large amount of strontium ions to remain in the complex, which will cause the material to produce harmful effects in the body. If the strontium element is added less, the Eucommia polysaccharide is excessive, and the complexation reaction is insufficient.

[0033] In one embodiment, step S110 includes: respectively disso...

Embodiment 1

[0051] The preparation process of the Eucommia polysaccharide strontium complex of the present embodiment is as follows:

[0052] (1) dissolving Eucommia polysaccharide in deionized water to prepare an aqueous solution of Eucommia polysaccharide with a concentration of 1g / mL; dissolving strontium chloride in deionized water to prepare an aqueous solution of strontium chloride with a concentration of 1.8mol / L; Dissolve sodium hydroxide in deionized water to prepare an aqueous sodium hydroxide solution with a concentration of 1.8 mol / L.

[0053] (2) Under the condition of room temperature, under the condition of continuous stirring and the pH value controlled by the use of aqueous sodium hydroxide solution to be 10, according to the mass molar ratio of eucommia polysaccharide and strontium element being 150g:1mol, add to the aqueous solution of eucommia polysaccharide The aqueous solution of strontium chloride, after the addition of the aqueous solution of strontium chloride is ...

Embodiment 2

[0057] The preparation process of the Eucommia polysaccharide strontium complex of the present embodiment is as follows:

[0058] (1) dissolving Eucommia polysaccharide in deionized water to prepare an aqueous solution of Eucommia polysaccharide with a concentration of 0.5g / mL; dissolving strontium chloride in deionized water to prepare an aqueous solution of strontium chloride with a concentration of 2mol / L; Dissolve sodium hydroxide in deionized water to prepare an aqueous sodium hydroxide solution with a concentration of 1.5 mol / L.

[0059] (2) Under the condition of room temperature, under the condition of continuous stirring and the pH value controlled by the use of aqueous sodium hydroxide solution to be 9, according to the mass molar ratio of eucommia polysaccharide and strontium element is 60g:1mol, add to the aqueous solution of eucommia polysaccharide The aqueous solution of strontium chloride, after the addition of the aqueous solution of strontium chloride is compl...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Concentrationaaaaaaaaaa
Login to view more

Abstract

The invention relates to a eucomman strontium complex and a preparation method and application thereof. The preparation method of the eucomman strontium complex comprises the following steps: under the condition that the pH is controlled to be 9-11, eucomman and a water-soluble strontium salt react in water, and reaction liquid is obtained; and an organic precipitant is added into the reaction liquid, then a still standing reaction is conducted, then through solid-liquid separation, precipitates are collected, and thus the eucomman complex is obtained. The eucomman strontium complex is small in toxicity and has good bone repair and arthropathy prevention and treatment effects.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a strontium complex of Eucommia polysaccharide and its preparation method and application. Background technique [0002] Strontium plays an important role in the formation of bones. Strontium can promote the proliferation of osteoblasts and pluripotent stem cells, improve bone metabolism, etc. However, free strontium ions are toxic in the body, and the application of strontium is difficult to develop. Contents of the invention [0003] Based on this, it is necessary to provide a preparation method of Eucommia polysaccharide strontium complex with less toxicity and better bone repair and joint disease prevention and treatment effects. [0004] In addition, a strontium complex of Eucommia polysaccharide and its application are also provided. [0005] A preparation method of Eucommia polysaccharide strontium complex, comprising the steps of: [0006] Under the condition of controlling...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K33/24A61K31/715A61P19/08A61P19/02
CPCA61K31/715A61K33/24A61P19/02A61P19/08A61K2300/00
Inventor 唐斌邓雨晴马粉波彭颖贺文琪李思敬
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap