Construction method of antibacterial cefquinome PK/PD model for livestock and application

Abstract

The invention discloses a construction method of an antibacterial cefquinome PK / PD model for livestock and an application. The specific contents of the construction method comprise detecting the drugsusceptibility of antibacterial cefquinome to haemophilus parasuis so as to obtain an MIC distribution range; determining the concentrations of free drugs in plasma samples of healthy model animals and disease model animals at different time points after drug administration to obtain drug-time curves by a liquid chromatography detection method; performing fitting on pharmacokinetics parameters ofdrugs by pharmacokinetics software to obtain PK parameters; researching the antibiotic action of the antibacterial on pathogenic bacteria under the condition of in vitro and half in vivo, and performing fitting on the time limitation relationship of the antibacterial to the pathogenic bacteria under the condition of in vitro and half in vivo to obtain PD parameters; establishing a half in vivo PK-PD model according to a Sigmoid Emax equation; and obtaining drug administration schemes under different drug administration objectives through a dosage calculating formula and Mlxplore software. According to the construction method disclosed by the invention, an optimization method is provided for a drug resistance resistant medication scheme of the cefquinome clinically, and production and propagation of bacterial drug resistance are relieved.

Description

technical field [0001] The invention belongs to the field of clinical medicine, and in particular relates to a construction method and application of a veterinary antibacterial drug cefquinome PK / PD model. Background technique [0002] In recent years, the isolation rate of Haemophilus parasuis isolated from pigs suffering from respiratory diseases is as high as 20%, and it is usually a highly virulent serotype. The high morbidity and mortality of Haemophilus parasuis have seriously threatened the development of the pig industry and become a major cause of death for piglets in nurseries in farms; and Haemophilus parasuis is easily associated with other viruses or respiratory pathogens Mixed infection increases the difficulty of treatment and brings huge economic losses to the pig industry worldwide. Because there are many serotypes of Haemophilus parasuis, the low cross-protection of vaccines is the main reason for the failure of prevention, and antibiotic treatment is the ...

AI Technical Summary

Problems solved by technology

However, during the clinical use of antibiotics, the phenomenon of abuse and irrational use occurs frequently, and the problem of bacterial resistance is increasing year by year, which leads to an increase in the mortality rate of animals infected with drug-resistant bacteria, causing huge economic losses, and even threatening human health. Safety, bacterial resistance issues have become global concerns

[0004] At present, there are few studies on the clinical dosing regimen of cefquinome against Haemophilus parasuis

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