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The treatment method of n-acetylcysteine ​​production waste liquid

A technology of acetylcysteine ​​and diacetylcysteine, which is applied in the field of treatment of N-acetylcysteine ​​production waste liquid, can solve the problems of environmental pollution, waste of resources, poor quality and the like, and achieves easy discharge standards, The effect of reducing the content of organic matter and improving the utilization rate of raw materials

Active Publication Date: 2022-06-17
WUHAN GRAND HOYO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome the disadvantages of the poor quality of recycled products of N-acetylcysteine ​​production waste liquid in the prior art, and direct discarding will cause environmental pollution and waste of resources, etc., and provides a kind of N-acetylcysteine -Treatment method of acetylcysteine ​​production waste liquid

Method used

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  • The treatment method of n-acetylcysteine ​​production waste liquid
  • The treatment method of n-acetylcysteine ​​production waste liquid
  • The treatment method of n-acetylcysteine ​​production waste liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] (1) Concentration

[0050] 1000 mL of waste liquid was concentrated under reduced pressure, the volume was concentrated to about 500 mL, the concentration was stopped, and the concentrated solution was transferred to the reaction vessel.

[0051] (2) Zinc powder reduction

[0052] Add 30% liquid caustic soda to the concentrated solution, adjust the pH to 3-5, add 6g of zinc powder in two times within 20 minutes, heat and stir, control the temperature to 50-60°C, and keep stirring for about 1 hour. The molar ratio of zinc powder to N,N'-diacetylcysteine ​​in the waste liquid was 2.15:1.

[0053] (3) Acylation reaction

[0054] Add 30% caustic soda to the reaction solution to adjust pH to 8.56, control the temperature at 40-60°C, add 40.6 g of acetic anhydride dropwise, control the dropwise addition time within 20-40min, and pH 7.02 after the dropwise addition of acetic anhydride. The molar ratio of acetic anhydride to cysteine ​​in the waste liquid is 1.10:1.

[0055...

Embodiment 2

[0062] (1) Concentration

[0063] 1000 mL of waste liquid was concentrated under reduced pressure, the volume was concentrated to about 500 mL, the concentration was stopped, and the concentrated solution was transferred to the reaction vessel.

[0064] (2) Zinc powder reduction

[0065] Add 30% liquid caustic soda to the concentrated solution, adjust the pH to 3-5, add 9g of zinc powder in two times within 20 minutes, heat and stir, control the temperature to 50-60°C, and keep stirring for about 1 hour. The molar ratio of zinc powder to N,N'-diacetylcysteine ​​in the waste liquid was 3.2:1.

[0066] (3) Acylation reaction

[0067] Add 30% liquid caustic soda to the reaction solution to adjust pH to 8.51, control the temperature at 40-60°C, add 44.7g of acetic anhydride dropwise, control the dropwise addition time within 20-40min, and pH 7.03 after the dropwise addition of acetic anhydride. The molar ratio of acetic anhydride to cysteine ​​in the waste liquid is 1.2:1.

[...

Embodiment 3

[0075] (1) Concentration

[0076] 1000 mL of waste liquid was concentrated under reduced pressure, the volume was concentrated to about 500 mL, the concentration was stopped, and the concentrated solution was transferred to the reaction vessel.

[0077] (2) Zinc powder reduction

[0078] Add 30% liquid caustic soda to the concentrated solution, adjust the pH to 3-5, add 9g of zinc powder in two times within 20 minutes, heat and stir, control the temperature to 50-60°C, and keep stirring for about 1 hour. The molar ratio of zinc powder to N,N'-diacetylcysteine ​​in the waste liquid was 3.2:1.

[0079] (3) Acylation reaction

[0080] Add 30% caustic soda to the reaction solution to adjust pH to 7.60, control the temperature at 40-60°C, add 39.2 g of acetic anhydride dropwise, control the dropwise addition time within 20-40min, and pH 4.68 after the dropwise addition of acetic anhydride. The molar ratio of acetic anhydride to cysteine ​​in the waste liquid is 1.06:1.

[0081]...

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Abstract

The invention discloses a treatment method for N-acetylcysteine ​​production waste liquid. The method comprises the following steps: (1) adjusting the pH of the N-acetylcysteine ​​production waste liquid to 2-5, and then performing a reduction reaction with a reducing agent; (2) converting the pH of the reaction liquid obtained in step (1) to 2-5. The pH is adjusted to 7.5-8.6, followed by acylation reaction with acetic anhydride, and then separated; wherein, the reducing agent is zinc powder, tin powder, magnesium powder or dithiothreitol. The treatment method of the present invention fully recovers the substances in the production waste liquid, improves the utilization rate of raw materials, and the quality of the recycled product is good, and the specific rotation is +22.2°~+23.2°; at the same time, the content of organic matter in the waste water is reduced, so that Wastewater treatment is easier to meet discharge standards.

Description

technical field [0001] The present invention relates to a treatment method of N-acetylcysteine ​​production waste liquid. Background technique [0002] N-acetylcysteine ​​(Acetylcysteine, Ac-Cys), chemical name is N-acetyl-L-cysteine, molecular formula: C 5 H 8 NO 3 S, molecular weight: 162.1875. This product is a white crystalline powder; it has a garlic-like odor and sour taste; it has hygroscopic properties. Soluble in water, soluble in ethanol, insoluble in dichloromethane and ether. [0003] [0004] N-acetylcysteine ​​is a mucolytic agent, which is suitable for dyspnea caused by a large amount of sticky phlegm obstruction and dyspnea, and can also be used for postoperative dyspnea, acute and chronic bronchitis, bronchiectasis, pneumonia, Tuberculosis, emphysema, etc., which cause thick sputum and difficulty in expectoration, are now mostly used for the treatment of idiopathic interstitial lung. In recent years, studies have found that the 3% aqueous solution o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C319/12C07C323/52
CPCC07C319/12C07C323/52
Inventor 黄蕾李建华李敬梅雪臣何韺
Owner WUHAN GRAND HOYO
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