Polyurethane urea, preparation method thereof and super-tough polyurethane urea based thereon

A technology based on polyurethane urea and polyester, which is applied in the fields of biomedical polymer materials and supramolecular chemistry, can solve problems such as insufficient mechanical properties and insufficient cell affinity, and achieve improved mechanical properties, good biocompatibility and Effect of improving degradability and tensile strength at break

Inactive Publication Date: 2019-12-31
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, polymer bone repair materials that have been approved for clinical operation include polylactide (PLA), polycaprolactone (PCL), polylactic acid polyglycolic acid copolymer (PLGA), etc., but they still perform poorly in practical applications. However, it has defects such as insufficient mechanical properties and insufficient cell affinity, so it needs to be modified to synthesize bone repair materials with excellent performance

Method used

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  • Polyurethane urea, preparation method thereof and super-tough polyurethane urea based thereon
  • Polyurethane urea, preparation method thereof and super-tough polyurethane urea based thereon
  • Polyurethane urea, preparation method thereof and super-tough polyurethane urea based thereon

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Experimental program
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Effect test

Embodiment 1

[0057] This embodiment provides three kinds of polyurethane urea and the super-tough polyurethane urea synthesis method based on the above three kinds of polyurethane urea, the specific steps are as follows:

[0058] Dissolve polycarbonate diol (PCDL) with a molecular weight of 2000 g / mol, isophorone diisocyanate (IPDI), and dimethylol butyric acid (DMBA) in DMAC solution, and then add 10 μL of catalyst dibutyltin dilaurate , Reaction at 70°C for 4h. Control the molar ratio of reactant, namely PCDL:DMBA:IPDI=2mol:1mol:nmol. In this embodiment, the values ​​of n are 12, 15 and 18 respectively. After the reaction was completed, the temperature was lowered to 50°C, and 2(n-3)mol H 2 O continued to react for 48h. After the reaction, the reaction solution was slowly poured into ether to obtain a white flocculent solid. The product was washed with ether, dried, dissolved in DMAC, poured into a polytetrafluoroethylene mold, and dried at 70°C to obtain a polyurethaneurea film afte...

Embodiment 2

[0065] This embodiment provides a polyurethane urea and a method for synthesizing a super-tough polyurethane urea based on the above-mentioned polyurethane urea. The specific synthesis steps are as follows:

[0066] PLA with a molecular weight of 2000 g / mol and PCDL with a molecular weight of 2000 g / mol were mixed at a molar ratio of 1:1 and dissolved in DMAC solution, adding isophorone diisocyanate and dimethylol butyric acid, and then adding 10 μL of catalyst two Dibutyltin laurate, react at 70°C for 4h. Control the molar ratio of reactant, namely PLA+PCDL:DMBA:IPDI=2mol:1mol:12mol. Cool down to 50°C, add 18mol H 2 O continued to react for 60h. After the reaction, the reaction solution was slowly poured into ether to obtain a white flocculent solid. Wash the product with ether and dry it, dissolve it in DMAC, pour it into a polytetrafluoroethylene mold, and wait for the solvent to evaporate and dry at 70°C to obtain a polyurethane urea film, which is named PCPLAU 2-12.

...

Embodiment 3

[0072] This embodiment provides a polyurethane urea with high strength, and the specific preparation steps are as follows:

[0073] Polycarbonate diol (PCDL) with a molecular weight of 2000 g / mol, HMDI, and dimethylolbutyric acid (DMBA) were dissolved in DMAC solution, and then 10 μL of catalyst dibutyltin dilaurate was added, and reacted at 70°C for 4 h. The molar ratio of the reactants is controlled, namely PCDL:DMBA:HMDI=2mol:1mol:15mol. Cool down to 50°C, add 24mol H 2 O continued to react for 48h. After the reaction, the reaction solution was slowly poured into ether to obtain a white flocculent solid. Wash the product with ether and dry it, dissolve it in DMAC, pour it into a polytetrafluoroethylene mold, and wait for the solvent to evaporate and dry at 70°C to obtain polyurethane urea with high strength.

[0074] The characteristic of this embodiment is to use polycarbonate diol and alicyclic diisocyanate HMDI, chain extender diol DMBA to synthesize polyurethane urea...

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Abstract

The invention relates to degradable polyurethane urea containing multiple ureido groups and having excellent mechanical properties, a preparation method thereof and super-tough polyurethane urea basedthereon. The preparation method of the polyurethane urea includes: adding excessive diisocyanate and a catalyst into an organic solvent of oligomer diol and chain extender diol to carry out prepolymerization reaction, and then adding water as a chain extender for reaction. The content of ureido in a molecular chain can be regulated by adjusting the molar ratio of polyester diol to diisocyanate. The super-tough polyurethane urea can be further prepared on the basis of the polyurethane urea, molecular chain orientation is carried out on the super-tough polyurethane urea at high temperature, andthe super-tough polyurethane urea is fixed for a certain period of time under a tensile state at certain elongation, so that the molecular chain can be fully directionally arranged, thus further improving the mechanical strength. The polyurethane urea provided by the invention has the characteristics of high tensile strength and degradability, and has application prospects in the field of biomedical materials.

Description

technical field [0001] The invention relates to the fields of biomedical polymer materials and supramolecular chemistry, in particular to a degradable polyurethane urea with excellent mechanical properties, a preparation method thereof, and a super-tough polyurethane urea based thereon. Background technique [0002] Polyurethane (PU) is a kind of block copolymer formed by polycondensation of hydroxyl-terminated macromolecular diol, diisocyanate and small molecular diol or diamine. Its molecular chain is composed of soft segments and hard segments alternately, oligomer diols (polyester, polyether, etc.) form soft segments, and diisocyanate and small molecule chain extenders form hard segments. By adjusting the types of raw materials and the ratio of soft and hard segments, the macroscopic mechanical properties of polyurethane can be effectively adjusted to meet the needs of different fields. [0003] Due to their good mechanical properties, biocompatibility and degradability...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/75C08G18/66C08G18/44C08G18/42C08G18/34C08G18/32C08G18/30C08G18/12C08J5/18C08L75/02
CPCC08G18/12C08G18/3206C08G18/348C08G18/4202C08G18/4277C08G18/428C08G18/44C08G18/6659C08G18/755C08G18/758C08J5/18C08J2375/02C08G18/302
Inventor 郭明雨李钦
Owner SUZHOU UNIV
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