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Preparation method for strontium-containing biological film layer

A technology of biofilm layer and strontium solution, which is applied in coatings, pharmaceutical formulations, tissue regeneration, etc., can solve problems such as uneven distribution and low strontium content, and achieve improved biological activity, high production efficiency, and promotion of differentiation and bone formation Effect

Active Publication Date: 2019-12-31
GUANGDONG PROV MEDICAL INSTR INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In order to overcome the problems of low strontium content and uneven distribution in the preparation of strontium-containing biofilm layers in the prior art, the object of the present invention is to provide a method for preparing strontium-containing biofilm layers

Method used

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  • Preparation method for strontium-containing biological film layer
  • Preparation method for strontium-containing biological film layer
  • Preparation method for strontium-containing biological film layer

Examples

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preparation example Construction

[0055] The invention provides a method for preparing a strontium-containing biofilm layer, which specifically comprises the following steps:

[0056] 1. Preparation of strontium-containing biofilm electrolyte

[0057] S1: Na 3 PO 4 , Ca(OH) 2 , glycerin, disodium edetate and water are mixed, and magnetically stirred to obtain a mixed solution;

[0058] S2: Sr(OH) 2 Dissolve in water and stir magnetically to obtain strontium liquid;

[0059] S3: Mix the mixed solution obtained in S1 and the strontium solution obtained in S2 under magnetic stirring to obtain a strontium-containing biofilm electrolyte;

[0060] The composition of the strontium-containing biofilm electrolyte is: 10g / L~20g / L Na 3 PO 4 ;1g / L~5g / L Ca(OH) 2 ;2mL / L~10mL / L Glycerol; 1mL / L~4mL / L Disodium EDTA; 1g / L~10g / L Sr(OH) 2 ; The solvent is ultrapure water.

[0061] 2. Preparation of strontium-containing biofilm layer

[0062] The valve metal is added into the electrolytic solution of the strontium-conta...

Embodiment 1

[0093] In this example, the components and concentrations of the strontium-containing biofilm layer electrolyte are: Na 3 PO 4 15g / L, Ca(OH) 2 3g / L, glycerol 5mL / L, EDTA-2Na 2mL / L, Sr(OH) 2 2g / L, the solvent is ultrapure water.

[0094] The preparation method of this example containing strontium biofilm layer electrolyte is:

[0095] ①First put Na 3 PO 4 , Ca(OH) 2 , EDTA-2Na and glycerol are mixed in the container with ultrapure water as the solvent according to the above ratio. The magnetic stirring speed is 300r / min, and the magnetic stirring time is 10min.

[0096] ②Under the action of magnetic stirring, the Sr(OH) 2 Dissolve in another small container according to the above ratio. The magnetic stirring speed is 300r / min, and the magnetic stirring time is 5min.

[0097] ③The configured 5g / L Sr(OH) 2 The electrolyte solution is slowly introduced into the above-mentioned mixed solution, and continues to mix under the action of magnetic force. The magnetic stir...

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Abstract

The invention discloses a preparation method for a strontium-containing biological film layer. Valve metal is added into a strontium-containing biological film layer electrolyte, micro-arc oxidation treatment is carried out under magnetic stirring, and the strontium-containing biological film layer is obtained on the surface of the valve metal. The preparation method for the strontium-containing biological film layer comprises the following steps: mixing Na3PO4, Ca(OH)2, glycerol, EDTA-2Na and water to obtain a mixed solution; dissolving Sr(OH)2 into water to obtain a strontium solution; mixing the mixed solution with the strontium solution; and carrying out a preparation process under the magnetic stirring. The electrolyte contains 5-30g / L of Na3PO4, 1-5g / L of Ca(OH)2, 2-10mL / L of glycerol, 1-4mL / L of EDTA-2Na and 1-10g / L of Sr(OH)2. According to the preparation method for the strontium-containing biological film layer, magnetic action is added in preparation for the film layer, so that the contents of strontium and phosphorus in the film layer are increased, the biological activity of the film layer is improved, the surface topography of the film layer is further improved, and the corrosion resistance of the film layer is improved.

Description

technical field [0001] The invention relates to the technical field of material surface treatment, in particular to a method for preparing a strontium-containing biofilm layer. Background technique [0002] In today's society, the incidence of fractures caused by traffic accidents, construction and sports is increasing, and in many cases, it is necessary to implant repair materials to assist the growth and healing of injured tissues. However, the current bone repair biomaterials have shortcomings such as small quantity, incomplete varieties and specifications, and difficulty in meeting the needs of clinical operations. Therefore, the development and research of bone repair materials can not only reduce the pain and suffering of patients, but also create greater economic benefits. Due to the special environment in which human bones are located, there are high requirements for the mechanical properties of bone repair materials. In addition, bone repair materials have no toxic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D11/30A61L27/04A61L27/30A61L27/32A61L27/50A61L27/54
CPCA61L27/047A61L27/306A61L27/32A61L27/50A61L27/54A61L2400/18A61L2420/02A61L2420/06A61L2430/02C25D11/024C25D11/026C25D11/30
Inventor 刘朋刘志聃黄德群刘群峰顾珩
Owner GUANGDONG PROV MEDICAL INSTR INST