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Preparation technology of difenidol hydrochloride tablets

A diphenidol hydrochloride and preparation technology, which is applied in the field of medicine, can solve the problems such as insignificant effect, and achieve the effects of low cost, reduced usage, and simple preparation process

Inactive Publication Date: 2020-01-03
仁和堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the basis of the patented technology, combined with the records of the efficacy of Gastrodia elata in the prior art, the applicant continued to conduct research on the treatment of vertigo on Gastrodia elata tablets; the results found that although the whole Gastrodia elata tablet has a certain curative effect, the effect is not significant

Method used

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  • Preparation technology of difenidol hydrochloride tablets
  • Preparation technology of difenidol hydrochloride tablets
  • Preparation technology of difenidol hydrochloride tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A kind of difenidol hydrochloride tablet, its prescription composition is as shown in table 1 below.

[0039] Table 1

[0040]

[0041] The production steps and process parameters of the above-mentioned tablet:

[0042] crush

[0043]According to the production instructions, potassium hydrogen tartrate is collected from the temporary storage room of raw and auxiliary materials and sent to the crushing room. The potassium hydrogen tartrate is crushed to 100 mesh with a universal grinder and sieved and weighed. Clean the machine until there are no visible foreign objects.

[0044] According to the production instructions, the difenidol hydrochloride raw material is collected from the raw and auxiliary material temporary storage room and sent to the crushing room. The difenidol hydrochloride raw material is pulverized twice to 120 mesh with a dust-absorbing crushing unit, and the particle size is measured with a laser particle size analyzer to control the particle siz...

Embodiment 2

[0090] The quality standards and storage requirements of finished products, raw and auxiliary materials, and the quality standards of difenidol hydrochloride tablets of the present invention are shown in Table 4.

[0091] Table 4

[0092]

[0093]

Embodiment 3

[0098] Electric stun test in mice.

[0099] Selection of experimental animals: clean-grade Kunming mice, weighing 20.5±1.7g.

[0100] Drug selection: in Example 1, Comparative Example 1 and Comparative Example 2, the dosage was 2 mg / kg; the model control group was given the same amount of normal saline; the way of administration was conventional intragastric administration.

[0101] Maze test: 40 Kunming mice were randomly divided into 4 groups, namely Example 1 Group, Comparative Example 1 Group, Comparative Example 2 Group, and Model Control Group; 10 mice in each group were administered by intragastric administration, morning and evening every day 1 time for each group, three-way maze training for 7 consecutive days at the same time, 2 times a day to establish the conditioned reflex for the mice to avoid electric shocks. 1 hour after the last administration, the maze training was performed once. Rotate at a constant speed of 200rpm for 60s and stop suddenly. Immediately pl...

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PUM

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Abstract

The invention belongs to the technical field of pharmaceuticals, and discloses a preparation technology of difenidol hydrochloride tablets. The preparation technology is characterized by comprising the following steps of step (1) performing crushing; step (2) weighing ingredients; step (3) compounding a 2% sodium carboxymethyl cellulose aqueous solution; step (4) preparing wet granules; step (5) performing drying; step (6) performing granule trimming; step (7) performing total mixing; step (8) performing tabletting; and step (9) performing coating.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation process of difenidol hydrochloride tablets. Background technique [0002] Motion sickness (motion sickness), that is, motion sickness, seasickness, airsickness, and diseases caused by swinging, bumping, rotating, and accelerated motion due to various reasons. China is one of the countries with the highest incidence of "motion sickness" in the world, and 80% of people have experienced different degrees of motion sickness. There is currently no complete cure for this disease, but choosing an effective anti-sickness drug can relieve the pain very well. Motion sickness occurs because the brain receives conflicting information from the sense organs: the eyes are unable to identify the mechanism (relationship between) the movement of the same control object and the movement of the vehicle to form a balance in the inner ear. The central nervous system's resp...

Claims

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Application Information

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IPC IPC(8): A61K9/28A61K47/36A61K47/38A61K36/8988A61K31/4453A61P1/08
CPCA61K9/28A61K9/2059A61K9/2054A61K36/8988A61K31/4453A61P1/08A61K2300/00
Inventor 林凡友孙永喜罗晓倩陈仁燕
Owner 仁和堂药业有限公司