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A kind of itraconazole ear drops for treating canine otitis and preparation method thereof

A technology of azole ear drops and itraconazole, which is applied in the field of itraconazole ear drops for the treatment of canine otitis and its preparation, can solve the problems of difficult cleaning and uncertain effect, and achieve uniform distribution and stable quality , the effect of improving solubility

Active Publication Date: 2021-09-28
天津市保灵动物保健品有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the compound suspension-type ear drops is made into an oil solvent, and it is difficult to clean the ear canal of dogs and cats after rubbing it. Especially in clinical practice, this product is often used in conjunction with ear clearing liquid. Due to the separation of oil and water, the effect is uncertain.

Method used

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  • A kind of itraconazole ear drops for treating canine otitis and preparation method thereof
  • A kind of itraconazole ear drops for treating canine otitis and preparation method thereof
  • A kind of itraconazole ear drops for treating canine otitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]prescription:

[0039]

[0040] Preparation:

[0041] 1) Add the amount of hydroxypropyl-β-cyclodextrin to distilled water, dissolve, to obtain solution A;

[0042] 2) Pull it in Eco Knzazole to 25 μm to obtain Elikrazole ultrafine powder, spare;

[0043] 3) The ready-to-use Equatonazole ultrafine powder is referred to, adding to solution A, heating to 80 ° C, stir until dissolved, to obtain solution B;

[0044] 4) Add time to the solution B to be dissolved, add the amount of sulfate, gentamycin, and add the amount of glycerol, stir to uniform, cool, add distilled water, filling, and Iranzole drip.

Embodiment 2

[0046] prescription:

[0047]

[0048]

[0049] Preparation:

[0050] 1) Add the amount of hydroxypropyl-β-cyclodextrin to distilled water, dissolve, to obtain solution A;

[0051] 2) Pull it in Elikrazole to 20 μm to obtain Elikrazole ultrafine powder, spare;

[0052] 3) The ready-to-use Equazole ultrafine powder is referred to by the calculation, and the solution A is added to 60 ° C, stirred to dissolve, resulting in solution B;

[0053] 4) Add time to the solution B to be dissolved, add the amount of sulfate, gentamycin, and add the amount of glycerol, stir to uniform, cool, add distilled water, filling, and Iranzole drip.

Embodiment 3

[0055] prescription:

[0056]

[0057] Preparation:

[0058] 1) Add the amount of hydroxypropyl-β-cyclodextrin to distilled water, dissolve, to obtain solution A;

[0059] 2) Pull it in Elikrazole to 30 μm to obtain Elikrazole ultrafine powder, spare;

[0060] 3) The ready-to-use Equazole ultrafine powder is referred to as the calculation is placed to the solution A, heated to 90 ° C, stirred to dissolve, to obtain solution B;

[0061] 4) Add time to the solution B to be dissolved, add the amount of sulfate, gentamycin, and add the amount of glycerol, stir to uniform, cool, add distilled water, filling, and Iranzole drip.

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Abstract

The invention belongs to the field of veterinary medicine, in particular to an itraconazole ear drop for treating canine otitis and a preparation method thereof. The itraconazole ear drops include the following components: 0.5-2 parts by weight of itraconazole, 0.1-0.2 parts by weight of betamethasone valerate, 0.1-1 parts by weight of gentamicin sulfate, hydroxypropyl 20-40 parts by weight of base-β-cyclodextrin and 10 parts by volume of glycerin. The quality of the itraconazole ear drops provided by the present invention for the treatment of canine otitis is stable, not only itraconazole and betamethasone valerate can be dissolved in the solvent well, but also gentamicin sulfate It can be well dissolved in solvents, has uniform distribution and stable quality, and overcomes the problem of uncertain effect caused by oil-water separation when it is used in conjunction with ear cleansing liquid.

Description

Technical field [0001] The present invention is in the field of veterinary medicine, in particular, it relates to ear drops itraconazole preparation and a method for treatment of canine otitis. Background technique [0002] With the development of urbanization in my country, the world's aging population growing phenomenon, as well as human living space is compressed gradually, people face to face fewer opportunities to communicate directly. Pet dogs as human beings life partner, the resolve loneliness, eliminate stress and stay home security and other aspects play an important role. Otitis is a common disease in dogs pet dogs, a higher incidence Should not treated early after onset, often irreparable damage. [0003] Canine otitis ear canal by a variety of causes such as inflammation caused by bacteria, fungi, mechanical damage, allergic diseases and the like, can be divided according to the position of incidence of Type 3: otitis externa, otitis media, and otitis. The presence o...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K47/69A61K31/573A61K31/496A61K31/7036A61P27/16A61P31/10A61P31/04
CPCA61K9/0046A61K9/08A61K31/496A61K31/573A61K31/7036A61K47/6951A61P27/16A61P31/04A61P31/10A61K2300/00
Inventor 王红英许新增齐俊河郭长林张伟王成龙
Owner 天津市保灵动物保健品有限公司
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