Natamycin polymer micelle eye drop and preparation method thereof

Abstract

The invention relates to a natamycin polymer micelle eye drop and a preparation method thereof, belongs to the technical field of ophthalmic disease treatment and aims to solve the problem that a conventional natamycin eye drop is too high in use frequency. The invention provides the natamycin polymer micelle eye drop which comprises a natamycin polymer micelle and a phosphate buffer in a certainmass volume ratio, wherein the natamycin polymer micelle comprises 10-30% in mass percentage of natamycin and the balance of a polyethylene glycol-polymethylacrylic acid glyceride block copolymer. Thepolyethylene glycol-polymethylacrylic acid glyceride block copolymer is put into ethanol to form a cross-linking micelle through self assembling, and the natamycin is coated by the micelle to preparethe natamycin polymer micelle eye drop, so that the release time of the natamycin can be prolonged, the medicine use times can be reduced, the problem that the patient compliance is poor because of frequent medicine use can be solved, the eye drop has excellent properties of high medicine carrying, slow release, safety, non-toxicity, and the like, and mycotic keratitis can be treated with eye dropping of low frequency.

Description

technical field [0001] The invention belongs to the technical field of ophthalmic disease treatment, and in particular relates to a natamycin polymer micelle eye drop and a preparation method thereof. Background technique [0002] Fungal keratitis is an infectious corneal disease caused by pathogenic fungi with a high rate of blindness. If the diagnosis and treatment are not timely, not only visual impairment, but also serious eye complications such as corneal perforation and endophthalmitis will occur. Natamycin eye drops are the only eye drops approved by the US Food and Drug Safety Administration (FDA) for the control of fungal keratitis, and have the advantages of broad antibacterial spectrum and few adverse reactions. However, the frequency of administration of natamycin eye drops is relatively high: once every 1-2 hours at the beginning, after 3-4 days, change to 6-8 times a day for about 14-21 days. Such a high frequency of medication leads to poor patient complianc...

AI Technical Summary

Problems solved by technology

[0003] In order to solve the problem that the frequency of administration of the existing natamycin eye drops is too high, the invention provides a kind of natamycin polymer micellar eye drops and a preparation method thereof

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