Preparation method and application of functionalized graphene modified glassy carbon electrode

A glassy carbon electrode and graphene technology, applied in the direction of material electrochemical variables, material analysis through electromagnetic means, instruments, etc., can solve the problems of slow electron transfer rate, easy adsorption of oxidation products, inaccurate detection results, etc., and achieve good results. reproducible effect

A glassy carbon electrode and graphene technology, applied in the direction of material electrochemical variables, material analysis through electromagnetic means, instruments, etc., can solve the problems of slow electron transfer rate, easy adsorption of oxidation products, inaccurate detection results, etc., and achieve good results. reproducible effect

CN110672691AActive Publication Date: 2020-01-10SICHUAN UNIVERSITY OF SCIENCE AND ENGINEERING
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  • Preparation method and application of functionalized graphene modified glassy carbon electrode

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Embodiment l

[0023] A preparation method for a functionalized graphene-modified glassy carbon electrode, comprising the steps of:

[0024] 1) Pretreatment of glassy carbon electrodes

[0025] The glassy carbon electrodes were sequentially coated with 1.0, 0.3, 0.05 μm Al 2 o 3 The powder was polished to a mirror surface, and then ultrasonically washed 3 times in twice distilled water and absolute ethanol, each time for 3 minutes, N 2 Dry and set aside for use to prepare a pretreated electrode.

[0026] 2) Activation of pretreatment electrodes

[0027] at 1.0 x 10 -3 mol / L K 3 [Fe(CN) 6 ] The pretreated electrode was electrochemically activated by cyclic voltammetry in the solution.

[0028] 3) Preparation of copper-doped γ-ureapropyltriethoxysilane functionalized graphene oxide

[0029] Weigh 1.00g of graphene oxide and dissolve it in 500mL of absolute ethanol, sonicate for 2 hours to obtain a graphene oxide solution, transfer it to a reaction kettle, and then add 0.15g of γ-ureapr...

Embodiment 2

[0033] A preparation method for a functionalized graphene-modified glassy carbon electrode, comprising the steps of:

[0034] 1) Pretreatment of glassy carbon electrodes

[0035] The glassy carbon electrodes were sequentially coated with 1.0, 0.3, 0.05 μm Al 2 o 3 The powder was polished to a mirror surface, and then ultrasonically washed 3 times in twice distilled water and absolute ethanol, each time for 3 minutes, N 2 Dry and set aside for use to prepare a pretreated electrode.

[0036] 2) Activation of pretreatment electrodes

[0037] at 1.0 x 10 -3 mol / L K 3 [Fe(CN) 6 ] The pretreated electrode was electrochemically activated by cyclic voltammetry in the solution.

[0038] 3) Preparation of nickel-doped γ-ureapropyltriethoxysilane functionalized graphene oxide

[0039]Weigh 1.00g of graphene oxide and dissolve it in 500mL of absolute ethanol, sonicate for 2 hours to obtain a graphene oxide solution, transfer it to a reaction kettle, and then add 0.18g of γ-ureapro...

Embodiment 3

[0043] A preparation method for a functionalized graphene-modified glassy carbon electrode, comprising the steps of:

[0044] 1) Pretreatment of glassy carbon electrodes

[0045] The glassy carbon electrodes were sequentially coated with 1.0, 0.3, 0.05 μm Al 2 o 3 The powder was polished to a mirror surface, and then ultrasonically washed 3 times in twice distilled water and absolute ethanol, each time for 3 minutes, N 2 Dry and set aside for use to prepare a pretreated electrode.

[0046] 2) Activation of pretreatment electrodes

[0047] at 1.0 x 10 -3 mol / L K 3 [Fe(CN) 6 ] The pretreated electrode was electrochemically activated by cyclic voltammetry in the solution.

[0048] 3) Preparation of iron-doped γ-ureapropyltriethoxysilane functionalized graphene oxide

[0049] Weigh 1.00g of graphene oxide and dissolve it in 500mL of absolute ethanol, sonicate for 2 hours to obtain a graphene oxide solution, transfer it to a reaction kettle, and then add 0.35g of γ-ureaprop...

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Abstract

The invention discloses a preparation method and application of a functionalized graphene modified glassy carbon electrode. The preparation method comprises the following steps of modifying a surfaceof the polished glassy carbon electrode by adopting a modifier containing metal-doped gamma-ureidopropyltriethoxysilane functionalized graphene oxide with effective concentration after electrochemically activating the polished glassy carbon electrode, thereby obtaining the functionalized graphene modified glassy carbon electrode. The invention further discloses application of the functionalized graphene modified glassy carbon electrode in detecting the concentration of epinephrine in an electrochemical method. The problems that the traditional electrode detection is slow in response, narrow indetection range and low in sensitivity due to the defects that the epinephrine is slow in electron transfer rate on a bare electrode and the oxidation products are easy to adsorb are solved by utilizing the unique electrocatalytic property of graphene oxide. The testing method disclosed by the invention is good in reproducibility and stability, and can be used for measuring the concentration of the epinephrine hydrochloride, and has the features of being fast, sensitive and accurate.

Description

technical field [0001] The invention belongs to the technical field of electrochemical method detection, and in particular relates to a preparation method and application of a functionalized graphene-modified glassy carbon electrode. Background technique [0002] Adrenaline is a catecholamine neurotransmitter, which plays a very important role in the normal activities of the human body, and the level of the content in body fluids will affect the health of the person. Therefore, the concentration detection of epinephrine and its metabolites is very important in drug analysis and clinical diagnosis. At present, a series of methods for detecting the concentration of epinephrine have been developed, such as high performance liquid chromatography, biosensor method, spectrophotometry, chemiluminescence method, fluorescence method, electrochemical method, capillary electrophoresis, etc. [0003] The essence of adrenaline oxidation reaction is electron transfer. Since the epinephr...

Claims

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Application Information

Patent Timeline
10 Jan 2020
Publication
CN110672691A
IPC
G01N27/327; G01N27/30
CPC
G01N27/3277; G01N27/3278; G01N27/308
Inventors
李明田; 肖丽丽