Tunable plasmon tweezers device, system and method based on terahertz waveband

A plasmonic and terahertz technology, applied in the field of optical tweezers, can solve the problems of complex, poor biocompatibility, non-tunable structure, etc., and achieve the effect of good biocompatibility, strong selectivity and simple structure

Active Publication Date: 2020-01-14
XI AN JIAOTONG UNIV +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] In view of the above problems, a tunable plasmonic tweezers device, plasmonic tweezers system and plasmonic tweezers method based on the terahertz band are proposed, using terahertz electromagnetic waves with good biocompatibility as the radiation source , by controlling the external field voltage to adjust the response frequency of the incident electromagnetic wave and the local field intensity; to overcome the traditional laser optical tweezers, visible light, near-infrared light metamaterial plasmonic tweezers have poor biocompatibility, non-tunable or complex structures, etc. Problem: To achieve selective non-destructive, non-ionized capture and manipulation of different types of living biological samples (such as cells, organelles, and biomacromolecules), and to further expand the application of optical tweezers in the field of biomedicine

Method used

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  • Tunable plasmon tweezers device, system and method based on terahertz waveband
  • Tunable plasmon tweezers device, system and method based on terahertz waveband
  • Tunable plasmon tweezers device, system and method based on terahertz waveband

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Embodiment 1

[0051] Example 1: When this patent is applied to the traditional medical optical tweezers system, the low-energy terahertz electromagnetic waves are locally focused and enhanced by using specially designed tunable plasmonic tweezers in the terahertz band, and then formed around the slot-shaped array Three-dimensional potential well for trapping biological particles. In addition, according to different biological samples 7 absorbing terahertz waves of different wavelengths, it is only necessary to control the external field voltage of the graphene in the middle layer 3, and adjust the response frequency of incident terahertz electromagnetic waves and the enhancement of electric field strength to achieve plasma The tuning of the capture range and capture capacity of the excimer tweezers finally realizes the selective non-destructive, non-ionized capture and manipulation of different types of biological samples7 (such as living cells, biomacromolecules, etc.).

Embodiment 2

[0052] Example 2: By fusing traditional selective molecular sensing techniques, the present invention can be used to develop biomolecular recognition sensors with high sensitivity. When the dielectric properties of the tested biological sample 7 change, the transmission characteristics of the terahertz wave through the terahertz band metamaterial will change accordingly, and the THz detector can identify the biological information carried by the tested object by detecting this change . Similarly, by controlling the external field voltage of the graphene in the middle layer 3, the response frequency of the incident terahertz electromagnetic wave and the enhancement of the electric field strength can be adjusted to achieve accurate and selective capture and detection of different biological samples 7 . As a new biomolecular recognition technology, the sensing technology based on the proposed tunable plasmonic tweezers in the terahertz band also has the following characteristics:...

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Abstract

The invention discloses a tunable plasmon tweezers device, a plasmon tweezers system and a plasmon tweezers operation method thereof based on terahertz waveband, wherein in the tunable plasmon tweezers device, a middle layer is laminated on a base layer, and an upper layer is laminated on the middle layer and comprises periodic groove arrays; the plasmon tweezers system comprises a terahertz generation module, a transmission and focusing module, a capturing and observing module and a detection and post-processing module; the plasmon tweezers operation method comprises the following steps of radiating terahertz electromagnetic waves to the tunable plasmonic tweezers device, wherein geometries and / or sizes of grooves enable the terahertz electromagnetic waves to be locally focused inside thegrooves to form three-dimensional potential well forces inside the grooves, and an object to be captured is captured in the grooves through the three-dimensional potential well forces.

Description

technical field [0001] The invention relates to the technical field of optical tweezers, in particular to a tunable plasmonic tweezers device based on a terahertz band, a plasmonic tweezers system and a plasmonic tweezers operating method thereof. Background technique [0002] Optical tweezers are a technology that traps objects with light. It uses light to form a three-dimensional potential well to bind objects, and then manipulates objects at the micro-nano scale by moving the beam. Because optical tweezers can capture and manipulate particles with high precision and non-contact without causing mechanical damage to the particles or affecting the environment around the particles, it is widely used in biomedicine such as cell manipulation, virus detection, and biomolecular sensing. The field has attractive application prospects. [0003] Laser optical tweezers technology usually uses a high numerical aperture objective lens to focus the incident laser light to form a beam ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G02B5/00
CPCG02B5/008
Inventor 张留洋沈忠磊陈雪峰徐亚飞韩东海翟智孙瑜
Owner XI AN JIAOTONG UNIV
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