Medicine-loaded long-cycle modified nanometer montmorillonite clay material and preparation method thereof
A nano-montmorillonite, long-cycle technology, applied in the field of biomedical materials, can solve the problems of short half-life, insufficient drug loading, large toxic and side effects, etc., and achieve the effects of enhanced adsorption performance, difficult metabolism, and small burst release effect.
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Embodiment 1
[0028] Step 1: Soak montmorillonite K-10 in 50g / L sulfuric acid solution, stir for 2h, then dry, calcinate at 300°C for 4h, then soak in 20g / L sodium polyphosphate solution at 60°C, stir for 12h, then Drying, calcining at 300°C for 4 hours, and then grinding and sieving to obtain activated montmorillonite with a particle size of <120nm;
[0029] Step 2: Dissolve 3 mg of doxorubicin in 300 ml of PBS buffer solution with pH 7.4, mix with 30 mg of activated montmorillonite and 30 mg of graphene, and then spray dry. h prepared drug-loaded montmorillonite;
[0030] Step 3: 3 mg of drug-loaded montmorillonite is activated by plasma treatment. The plasma treatment conditions are as follows: the gas is oxygen, the treatment power is 280 W, the pressure is 55 Pa, and the treatment time is 12 minutes. Under the condition of vacuum degree of 0.024mBar, it was dispersed in 15ml of PBS buffer solution together with 8mg of serine, and freeze-dried at -40°C and 0.020mBar to prepare the drug...
Embodiment 2
[0033] Step 1: Soak montmorillonite K-10 in 50g / L sulfuric acid solution, stir for 2h, then dry, calcinate at 300°C for 4h, then soak in 20g / L sodium polyphosphate solution at 60°C, stir for 12h, then Drying, calcining at 300°C for 4 hours, and then grinding and sieving to obtain activated montmorillonite with a particle size of <120nm;
[0034] Step 2: Dissolve 5 mg of doxorubicin in 100 ml of PBS buffer at pH 7.4, mix with 10 mg of activated montmorillonite and 10 mg of graphene, and then spray dry. h prepared drug-loaded montmorillonite;
[0035] Step 3: 1 mg of drug-loaded montmorillonite is activated by plasma treatment. The plasma treatment conditions are as follows: the gas is nitrogen, the treatment power is 250 W, the pressure is 50 Pa, and the treatment time is 10 minutes. Under the condition of vacuum degree of 0.010mBar, it was dispersed in 5ml of PBS buffer solution together with 2mg of serine, and freeze-dried at -50°C and 0.010mBar to prepare the drug-loaded lo...
Embodiment 3
[0037] Step 1: Soak montmorillonite K-10 in 50g / L sulfuric acid solution, stir for 2h, then dry, calcinate at 300°C for 4h, then soak in 20g / L sodium polyphosphate solution at 60°C, stir for 12h, then Drying, calcining at 300°C for 4 hours, and then grinding and sieving to obtain activated montmorillonite with a particle size of <120nm;
[0038] Step 2: Dissolve 1 mg of paclitaxel in 500 ml of PBS buffer solution with pH 7.4, mix it with 50 mg of activated montmorillonite and 50 mg of graphene, and then spray dry it with an air inlet temperature of 160°C and a feed flow rate of 1 L / h Drug-loaded montmorillonite;
[0039] Step 3: Activate 5 mg of drug-loaded montmorillonite through a plasma processor. The plasma treatment conditions are as follows: the gas is oxygen, the processing power is 300 W, the pressure is 60 Pa, and the processing time is 15 minutes. Under the condition of vacuum degree of 0.060mBar, it was dispersed in 20ml of PBS buffer solution together with 10mg of...
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