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A liquid metal-based visualized drug-loaded embolic microsphere and its preparation method

A liquid metal and drug-loaded technology, applied in the field of medical materials, can solve problems such as poor developing effect, single drug loading, and small drug loading

Active Publication Date: 2020-10-20
TSINGHUA UNIV
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  • Abstract
  • Description
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Problems solved by technology

[0003] At present, the embolization microspheres commonly used in clinical practice mainly include DC Bead, HepaSphere, CalliSpheres, etc. However, they generally have problems such as poor imaging effect, small drug loading, and single drug loading.

Method used

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  • A liquid metal-based visualized drug-loaded embolic microsphere and its preparation method

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Embodiment Construction

[0022] The implementation of the present invention will be described in detail below with reference to the drawings and examples, but they are not used to limit the scope of the present invention.

[0023] A liquid metal-based visualized drug-loaded embolization microsphere, made of the following components by weight: 1 part of liquid metal (EGaIn, the mass ratio of metal gallium to metal indium is 75.5:24.5), 50 parts of chitosan aqueous solution , 1 part of antineoplastic drug, the resulting product is a solid powder, such as figure 1 As shown, liquid metal nanoparticles 2 and antitumor drugs 3 are wrapped by solid chitosan material 1 .

[0024] Its preparation method includes:

[0025] (1) Preparation of liquid metal nano solution: add 1 g of liquid metal in 50 ml of chitosan aqueous solution, ultrasonically disperse, remove large particles by centrifugation, and obtain a uniformly dispersed liquid metal nanoparticle solution in nano form, wherein the liquid metal concentr...

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Abstract

The invention relates to visual medicine-loaded embolic microspheres based on liquid metal and a preparation method of the visual medicine-loaded embolic microspheres based on liquid metal. The visualmedicine-loaded embolic microspheres comprise liquid metal, a chitosan aqueous solution and antitumor drugs in the mass ratio being 1:(10-100):(0.5-2). The visual medicine-loaded embolic microspheresadopt a physical crosslinking method, and the chitosan and a cross-linking agent are used for cross-linking to form the microspheres. The method is mild in preparation condition and simple to operate. The particle diameter of the visual medicine-loaded embolic microspheres is 10-700[mu]m, the size is controllable, the biocompatibility is good, the medicine-carrying properties are high, the medicine-carrying is wide in spectrum, and durable drug release and tumor vessel embolism can be realized. The visual medicine-loaded embolic microspheres also have the properties of DSA fluoroscopy or CT development and the like, assessment of treatment effect is convenient and timely, embolism is completed, and the visual medicine-loaded embolic microspheres can be used for TACE treatment for tumors.

Description

technical field [0001] The invention belongs to the technical field of medical materials, in particular to a liquid metal-based visualized drug-loaded embolic microsphere and a preparation method thereof. Background technique [0002] Interventional therapy is an emerging field developed in recent years. It is a minimally invasive medical technology guided by imaging equipment, and has the characteristics of small trauma, fast recovery, and good curative effect. Transcatheter arterial embolization is an important technique of interventional therapy. It injects embolic materials into the supply vessels of diseased organs in a controlled manner, so as to prevent blood flow and cause partial lack of oxygen and nutrient supply in tumor tissues, so as to achieve the goal of treating tumors and The purpose of removing diseased organs. [0003] At present, the embolization microspheres commonly used in clinic mainly include DC Bead, HepaSphere, CalliSpheres, etc. However, they gen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/04A61L24/08A61L24/02A61L24/00
CPCA61L24/0015A61L24/02A61L24/08A61L2300/416A61L2300/622A61L2400/12C08L5/08
Inventor 范琳琳段明辉张琳刘静
Owner TSINGHUA UNIV
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