Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A Preservation Solution for Stabilizing the Adsorption Performance of Adsorbent

A technology of adsorption performance and preservation of liquid, applied in the direction of selective adsorption, blood circulation treatment, other chemical processes, etc., can solve the problems of reduced adsorption performance of adsorbent, reduced adsorption efficiency of adsorption column, limited effect of adsorption performance of adsorbent, etc. The effect of stable adsorption performance and reduced drop rate

Active Publication Date: 2022-05-17
WUHAN RUIFA MEDICAL DEVICES CO LTD
View PDF11 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when high-pressure steam sterilization is used, the adsorption performance of the adsorbent is significantly reduced, resulting in a decrease in the actual adsorption efficiency of the adsorption column; at the same time, the adsorption performance of the adsorption column generally shows a slow decline within the validity period. The stabilizing effect of the liquid on the adsorption efficiency of the adsorbent during these two processes can maintain the effectiveness of the product
[0005] At present, commonly used preservation solutions include physiological saline and buffer solutions, among which, The preservation solution used in LA-15 adsorption column products is 0.04-0.08% (w / v) sodium citrate / citric acid solution, but under extreme conditions and long-term storage conditions, it has limited effect on stabilizing the adsorption performance of the adsorbent

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A Preservation Solution for Stabilizing the Adsorption Performance of Adsorbent
  • A Preservation Solution for Stabilizing the Adsorption Performance of Adsorbent
  • A Preservation Solution for Stabilizing the Adsorption Performance of Adsorbent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A preservation solution for stabilizing the adsorption performance of the adsorbent, consisting of polyacrylic acid, dextran 40 and phosphate buffer, wherein the mass volume ratio of polyacrylic acid, dextran 40 and phosphate buffer is 0.5g:0.8g:100mL , the pH of phosphate buffer is 6.5.

[0019] The adsorbent is a low-density lipoprotein adsorbent with polyacrylic acid as the ligand. The same batch of adsorbents is soaked in the above-mentioned filling solution, packed and sealed, and then sterilized by high-pressure steam. The stricter sterilization conditions are 121 ° C, 1 h . The adsorbent before and after sterilization was taken, washed with water and dried, and its adsorption performance was measured. Place the unopened sterilizing adsorbent at a temperature of 60±2°C and a humidity of 75±5% for an accelerated aging test, and take a sample on the 65th day, which is equivalent to the validity period of 24 months of real-time aging. After the adsorbent was washed...

Embodiment 2

[0024] A preservation solution for stabilizing the adsorption performance of an adsorbent, consisting of polymyxin B, dextran 40 and phosphate buffer, wherein the mass-to-volume ratio of polymyxin B, dextran 40 and phosphate buffer is 0.5 g:0.8g:100mL, the pH of the phosphate buffer is 6.5.

[0025] The selected adsorbent is an endotoxin adsorbent whose ligand is polymyxin B. The same batch of adsorbents is soaked in the above-mentioned filling solution, subpackaged and sealed, and then sterilized by high-pressure steam. The stricter sterilization condition is 121 ℃, 1h. Take the adsorbent before and after sterilization, wash and dry it with water, take 0.50g into a 10ml centrifuge tube or a conical flask, add 5ml of plasma containing 10EU / ml endotoxin, place on a shaker at a constant temperature of 37°C, shake at 120rpm for 2h, 3000r / min centrifugation for 5min, draw the supernatant and detect its endotoxin concentration with the chromogenic matrix limulus reagent method, c...

Embodiment 3

[0027] A kind of preservation solution for stabilizing adsorbent adsorption performance is made up of dextran sulfate, dextran 40 and phosphate buffer saline, wherein, the mass volume ratio of dextran sulfate, dextran 40 and phosphate buffer saline is 0.5g: 0.8g: 100mL, the pH of phosphate buffer is 6.5.

[0028] The selected adsorbent is a low-density lipoprotein adsorbent whose ligand is dextran sulfate, and adopts the same high-pressure sterilization method and aging method as in Example 1, and the adsorption performance of the adsorbent after corresponding treatment is measured.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preservation solution for stabilizing the adsorption performance of an adsorbent. The adsorbent includes microspheres and ligands grafted on the surface of the microspheres. The preservation solution includes free ligands that are consistent with the grafting on the surface of the microspheres. , a stabilizer and a base fluid, wherein the stabilizer is one or more of dextran and its derivatives, and the base fluid is buffer or physiological saline. The preservation solution can significantly reduce the decline rate of adsorption performance of various adsorbents in the high-pressure steam sterilization process and accelerated aging process, and has the function of stabilizing the adsorption performance.

Description

technical field [0001] The invention belongs to the field of adsorbents, in particular to a preservation solution for stabilizing the adsorption performance of adsorbents. Background technique [0002] Blood adsorption refers to a treatment method that drains the patient's blood out of the body, removes various pathogenic factors through the adsorption of the adsorbent, and achieves blood purification. Blood adsorption is an emerging treatment method, and its technical core lies in the adsorption performance of the adsorbent. [0003] The adsorption column is usually composed of adsorbent, preservation solution and column material, among which, the adsorbent is the core material, and the adsorbent is generally composed of a carrier and a ligand, and the ligand acts as an active molecule of the adsorbent to perform adsorption. It is used to form a sterile sealed environment, which can ensure the sterility of the internal environment of the adsorption column. The preservation...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61M1/36B01D15/08B01J20/26
CPCA61M1/36B01J20/26B01D15/08
Inventor 张媛王业富张磊陈梦林
Owner WUHAN RUIFA MEDICAL DEVICES CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com