Use of an extract for preparing anti-hepatic fibrosis drug and composition thereof
An anti-liver fibrosis and liver fibrosis technology, which can be used in drug combinations, medical raw materials derived from ferns/filamentous plants, and pharmaceutical formulations, and can solve complex problems.
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Embodiment 1
[0029] Example 1 Anti-inflammation and anti-hepatic fibrosis effects of different extraction parts of oriental dog ridge
[0030] 1. Animals and medicines
[0031] 1.1 Animals Healthy male SD rats, weighing 200±20g. Give standard feed and drinking water, drink water and diet freely, room temperature 22±1°C, humidity 60%-80%, and adapt to feeding for 7 days before starting the experiment.
[0032] 1.2 Drug The blank control drug is normal saline. The drug used in the research is the extract from different parts of the oriental dog ridge.
[0033] Wash and remove hair from Dongfang dog ridge fresh product, cut into 2mm slices, spread thinly and spread out to dry in the sun, and slice it as medicinal material for processing and extraction;
[0034] 1.2.1 Preparation of decoction extract of Oriental dog ridge
[0035] The oriental dog spine slices are crushed through a 20-mesh sieve, soaked in water for 2 hours according to the ratio of material to liquid 1:10, decocted 3 time...
Embodiment 2
[0055] Example 2 Research on Anti-hepatic Fibrosis Effect of Compound Drugs
[0056] 1. Animals and medicines
[0057] 1.1 Animals Healthy male SD rats, weighing 200±20g. Give standard feed and drinking water, drink water and diet freely, room temperature 22±1°C, humidity 60%-80%, and adapt to feeding for 7 days before starting the experiment.
[0058] 1.2 Drug The blank control drug is normal saline. The drugs used in the study are the extracts of Dongfang dogji, Astragalus, Bupleurum, Salvia, Radix Paeoniae Alba, Radix Paeoniae Rubra, Atractylodes macrocephala, and Poria cocos.
[0059] 1.2.1 Preparation of Ethyl Acetate Reflux Extract of Oriental dog spine
[0060] 600g of Dongfang dog spine slices were crushed through a 60-mesh sieve, and soaked in ethyl acetate for 2 hours according to the ratio of solid to liquid 1:30.
[0061] Reflux extraction at 70°C for 3 hours; collect the ethyl acetate extract by filtration, evaporate under reduced pressure to remove the ethyl ...
Embodiment 3
[0078] Example 3 Anti-hepatic fibrosis oral solid preparation of oriental dog ridge ethyl acetate extract
[0079] Take the oriental dog ridge ethyl acetate extract of embodiment 1 as example:
[0080] (1) Take oriental dog spine slices and crush them through a 60-mesh sieve, add ethyl acetate to soak for 2 hours according to the ratio of solid to liquid 1:30, and reflux at 70°C for 3 hours; filter to collect the ethyl acetate extract, and evaporate it under reduced pressure Ethyl acetate to obtain a paste extract.
[0081] (2) Take the paste extract of Oriental dog spines, add starch, mix with wet granulation, granulate with a 20-mesh sieve, granulate with a 20-mesh sieve, dry and pack to obtain oral granules.
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