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Medicinal and edible homologous composition for preventing and treating chronic alcoholic liver disease and application

A technology of alcoholic liver disease, medicine and food homology, applied in the field of medicine, can solve the problems of slow curative effect of traditional Chinese medicine, excessive dosage, toxic and side effects, etc., achieve lower MDA level, strong preventive effect, reduce cell fatty degeneration and inflammatory infiltration Effect

Inactive Publication Date: 2020-02-04
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the curative effect of traditional Chinese medicine is slow, and it needs more dosage or long-term medication, excessive or improper medication, which is prone to certain toxic and side effects; It has important application value in the prevention and treatment of medicine and food, but the efficacy and type selection of Chinese herbal medicines with the same source of medicine and food are often limited.

Method used

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  • Medicinal and edible homologous composition for preventing and treating chronic alcoholic liver disease and application
  • Medicinal and edible homologous composition for preventing and treating chronic alcoholic liver disease and application
  • Medicinal and edible homologous composition for preventing and treating chronic alcoholic liver disease and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 Chinese Medicine Composition for Preventing Chronic Alcoholic Liver Disease

[0041] Preparation of pharmaceutical composition

[0042] (1) Preparation of Salvia miltiorrhiza extract (DS): Clean 500g of Danshen decoction pieces, add 12 times the amount of distilled water, cook for 3.0 hours, and filter; add 10 times the amount of distilled water to the residue, continue cooking for 3.0 hours, and filter; then The two filtrates were heated at 60°C for 8 hours, and then filtered with double-layer filter paper, and the filtrate was placed in a rotary evaporator to obtain a concentrated solution; finally, the obtained concentrated solution was centrifuged in a centrifuge at a speed of 8000r / min for 20 minutes, and the supernatant was removed. Danshen extract.

[0043] (2) Preparation of Schisandra chinensis extract (WWZ): Clean 500g of Schisandra chinensis decoction pieces, add 12 times the amount of distilled water, cook for 3.0h, filter; add 10 times the amount...

Embodiment 2

[0046] Example 2 Construction of Animal Model of Chronic Alcoholic Liver Disease

[0047] C57 mice (4-week-old, female) were first given a liquid glucose diet (Bio Serv, USA) for 3 days to adapt to the liquid diet. Subsequently, mice in the model group will be fed a liquid ethanol diet (Bio Serv, USA) for 14 days. The control group continued to receive a liquid glucose diet (Bio Serv, USA) for 14 days. On the 15th day of feeding liquid ethanol, the mice in the model group were given 5 g / kg ethanol by intragastric administration once.

Embodiment 3

[0048] The effect of embodiment 3 Chinese medicine composition on animal model

[0049] 1. Experimental method

[0050] (1) Experimental grouping

[0051] Take the Chinese medicine composition prepared in Example 1 as an example for research.

[0052] The mice with chronic alcoholic liver disease were divided into a model control group and a Chinese medicine treatment group. The Chinese medicine treatment group included Danshen group (DS), Schisandra chinensis group (WWZ), Jiaogulan group (JGL), and liver-protecting Chinese medicine mixture group (LF). Each treatment group is divided into high-dose group (H), middle-dose group (M) and low-dose group (L). Through intragastric administration, the model control group was given the same dose of normal saline.

[0053] (2) Detection of relevant indicators

[0054] On the 16th day after feeding liquid ethanol, the mice were sacrificed by cervical dislocation, blood was collected from the heart, and the blood and liver homogenate...

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Abstract

The invention discloses a medicinal and edible homologous composition for preventing and treating chronic alcoholic liver disease. The composition comprises salvia miltiorrhiza, schisandra chinensis and gynostemma pentaphyllum. Researches find that, compared with a single drug extract and a model control group, the pharmaceutical composition disclosed by the invention can be used for remarkably reducing the levels of ALT and AST in the serum of a C57 mouse model, remarkably reducing the levels of MDA in the liver of the C57 mouse model, improving the levels of SOD and GSH-Px, reducing the phenomena of cell steatosis and inflammatory infiltration of the mouse model induced by alcohol, and has a remarkable synergistic effect on prevention and treatment of chronic alcoholic liver disease. Themedicinal and edible homologous medicinal composition provided by the invention is efficient and free of toxic and side effects, and has an important application value for preventing and treating chronic alcoholic liver disease.

Description

technical field [0001] The invention belongs to the technical field of medicine. More specifically, it relates to a medicine and food homologous composition and application for preventing and treating chronic alcoholic liver disease. Background technique [0002] Alcoholism-related diseases cause about 2.4 million deaths worldwide each year, accounting for about 3.5% of the total death population. At present, according to statistics, there are more than 50 diseases related to alcoholism, but most of the deaths related to alcoholism are induced by alcoholic liver disease. As a common liver disease, chronic alcoholic liver disease (Chronic Alcoholic liver disease, CALD) has been a research hotspot in the field of liver disease. Heavy and long-term drinking can lead to long-term accumulation of fat in the liver. When the fat accumulation in the liver cells exceeds 5% of the wet weight of the liver, or fatty degeneration occurs in more than 1 / 3 of the liver cells per unit area...

Claims

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Application Information

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IPC IPC(8): A61K36/79A61K36/57A61P1/16
CPCA61K36/424A61K36/537A61K36/57A61K36/79A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P1/16A61K2300/00
Inventor 洪明孙秉玉刘永强李伟荣王奇
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE