Application of quinidine or quinidine derivatives, botanical insecticide, quinidine derivatives and preparation method thereof
A technology of plant-derived insecticides and derivatives, applied in the field of plant-derived pesticides, can solve the problems of less research on insecticidal activity and no reports of preventive effects
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Embodiment 1-21
[0047] Example 1-21 9S-acyloxyquinidine derivatives 3a-u
[0048] According to the corresponding substituent R in Table 1 in the general structural formula I, 9S-acyloxyquinidine derivatives 3a-u can be obtained.
[0049]
[0050] Table 1: 9S-acyloxyquinidine derivatives 3a-u corresponding substituents R
[0051]
[0052]
Embodiment 22
[0054] The preparation method of 9S-acyloxyquinidine derivatives in Example 1-21 is as follows:
[0055] Weigh quinidine 1 (0.5mmol), corresponding carboxylic acid 2a-u (0.6mmol), N,N'-dicyclohexylcarbodiimide DCC (0.6mmol) and 4-(N,N-dimethyl Amino)pyridine DMAP (0.1 mmol) was placed in a 50 mL flask, and 10 mL of dichloromethane (calcium hydride dried and ready for use) was added to the above reaction solution, and the esterification reaction was carried out at room temperature for 24-96 h.
[0056] During the esterification reaction, TLC tracked and detected until the reaction of the raw materials was complete. A large amount of urea in the reaction solution was removed by filtration, and the filtrate was diluted with dichloromethane (40 mL). The diluted solution was successively washed once with 0.1 mol / L hydrochloric acid (25 mL), saturated sodium bicarbonate (25 mL) and saturated brine (25 mL), and dried over anhydrous sodium sulfate. The solvent was removed under redu...
Embodiment 23
[0210] A botanical insecticide, prepared from compound 3a and acetone in Example 1, the concentration of compound 3a is 1mg / mL.
[0211] In other embodiments of the plant pesticide, the active ingredient includes any one of the compounds 3b-u in the embodiments 2-21.
[0212] In other embodiments of the plant pesticide, the active ingredient only needs to include quinidine.
[0213] It can be made into powders, sprays, etc. by referring to the application methods of existing botanical insecticides, and can also be compounded with other types of insecticides.
[0214] The botanical insecticides in the present invention have little impact on the natural environment, and can be used alternately with other types of insecticides to improve the insecticidal effect.
[0215] The application of quinidine and 9S-acyloxyquinidine derivatives in the prevention and control of Lepidoptera pests in the present invention is realized through the following test examples.
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